DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and Dcn

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_077043.1	Gene:	Dcn / 29139	RGDID:	61895	Length:	354	Species:	Rattus norvegicus

Alignment Length:	346	Identity:	87/346 - (25%)
Similarity:	151/346 - (43%)	Gaps:	47/346 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 LLDLDLTGAAPINVHTNGFSILP-----NLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQME 141
            :|:.:.:|..|.:......|:.|     :||.:..|..||..:.. .|.|::.|  :|..:|::.
  Rat    28 MLEDEASGIIPYDPDNPLISMCPYRCQCHLRVVQCSDLGLDKVPW-EFPPDTTL--LDLQNNKIT 89

  Fly   142 LLDRDFFGNLR---KLIYAN-----FSHNALKQCDLPHMPL--LNRLELGHNRLVNATFGVCPQL 196
            .:....|.||:   .||..|     .|..|.|       ||  |.||.|..|.|......:...|
  Rat    90 EIKEGAFKNLKDLHTLILVNNKISKISPEAFK-------PLVKLERLYLSKNHLKELPEKLPKTL 147

  Fly   197 QELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLE--TFQPLAQLRKLNLSQNALDALRP 259
            |||.|:||::.:|..:.|.||:.::.::|.||.|.:.|:|  ..|.:..|..:.:|..
  Rat   148 QELRLHDNEITKLKKSVFNGLNRMIVIELGGNPLKNSGIENGALQGMKGLGYIRISDT------- 205

  Fly   260 NVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLY 324
            |:....|.....:.:|.|.||:|..:.....:.::.|..|.:|.|||..:.......:..||:|:
  Rat   206 NITAIPQGLPTSISELHLDGNKIAKVDAASLKGMSNLSKLGLSFNSITVVENGSLANVPHLRELH 270

  Fly   325 LQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMR-------RLNLNGNRMKH 382
            |..|.:|.: ||..|....:..:.|..||:..:.:..|   .||..:       .::|..|.:::
  Rat   271 LDNNKLLRV-PAGLAQHKYVQVVYLHNNNISEVGQHDF---CLPSYQTRKTSYTAVSLYSNPVRY 331

  Fly   383 --LHPLAFSSLPFLEYLKLGH 401
              :||..|..:.....::||:
  Rat   332 WQIHPHTFRCVFGRSTIQLGN 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	48/169 (28%)
		LRR_8	104..164	CDD:290566	18/72 (25%)
		leucine-rich repeat	106..129	CDD:275380	7/22 (32%)
		leucine-rich repeat	130..153	CDD:275380	6/25 (24%)
		leucine-rich repeat	154..195	CDD:275380	14/47 (30%)
		LRR_RI	194..455	CDD:238064	55/219 (25%)
		LRR_8	194..254	CDD:290566	20/61 (33%)
		leucine-rich repeat	196..219	CDD:275380	11/22 (50%)
		leucine-rich repeat	220..243	CDD:275380	7/24 (29%)
		leucine-rich repeat	244..267	CDD:275380	3/22 (14%)
		LRR_8	271..330	CDD:290566	16/58 (28%)
		leucine-rich repeat	272..295	CDD:275380	5/22 (23%)
		leucine-rich repeat	296..319	CDD:275380	6/22 (27%)
		LRR_8	319..380	CDD:290566	17/67 (25%)
		leucine-rich repeat	320..343	CDD:275380	9/22 (41%)
		leucine-rich repeat	344..369	CDD:275380	5/24 (21%)
		LRR_8	368..428	CDD:290566	8/43 (19%)
		leucine-rich repeat	370..393	CDD:275380	5/31 (16%)
		leucine-rich repeat	394..417	CDD:275380	2/8 (25%)
		leucine-rich repeat	418..441	CDD:275380
Dcn	NP_077043.1	LRRNT	48..80	CDD:214470	8/32 (25%)
		leucine-rich repeat	57..77	CDD:275380	6/20 (30%)
		PRK15370	<65..>329	CDD:185268	74/284 (26%)
		LRR 1	68..88		5/22 (23%)
		leucine-rich repeat	78..101	CDD:275380	6/24 (25%)
		LRR 2	89..112		6/22 (27%)
		leucine-rich repeat	102..125	CDD:275380	8/29 (28%)
		LRR 3	113..136		10/29 (34%)
		leucine-rich repeat	126..146	CDD:275380	6/19 (32%)
		LRR 4	137..157		7/19 (37%)
		leucine-rich repeat	147..170	CDD:275380	11/22 (50%)
		LRR 5	158..181		7/22 (32%)
		leucine-rich repeat	171..196	CDD:275380	7/24 (29%)
		LRR 6	182..207		5/31 (16%)
		leucine-rich repeat	197..217	CDD:275380	4/26 (15%)
		LRR 7	208..228		5/19 (26%)
		leucine-rich repeat	218..241	CDD:275380	5/22 (23%)
		LRR 8	229..252		4/22 (18%)
		leucine-rich repeat	242..265	CDD:275380	6/22 (27%)
		LRR 9	253..276		5/22 (23%)
		LRR 10	277..299		6/22 (27%)
		leucine-rich repeat	289..308	CDD:275380	4/21 (19%)
		LRR 11	300..329		5/31 (16%)
		leucine-rich repeat	312..339	CDD:275380	4/26 (15%)
		LRR 12	330..354		5/23 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910