DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and Podnl1

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_213845.6	Gene:	Podnl1 / 288907	RGDID:	1307753	Length:	582	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	154/554 - (27%)
Similarity:	226/554 - (40%)	Gaps:	123/554 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLLWLLCMGFPILHGAD------------LCQPIGWRNFQCSEVASLQDLVDLGAENWH------ 57
            |||.||.:.:|..|..|            |.:|..||   ||  ....|.||....:..
  Rat    20 LLLLLLLLRWPAAHTEDPAFPHLGDSSQPLPRPCPWR---CS--CPRDDTVDCAGLDLRVFPDNI 79

  Fly    58 TLAIRNVQ-----------TELEVGSG-ENADHLANLLDLD---------LTGAAPINVHTNGFS 101
            |.|.|::.           .||...|| ...|..:||:..:         ||......|..|..|
  Rat    80 TRAARHLSLQKNQLQELPYNELSRLSGLRTLDLHSNLISSEGLPDEAFESLTQLENFYVAHNKLS 144

  Fly   102 ILP-----NLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQME---LLDRDFFGNLRKLIYAN 158
            :.|     :||..:|:...:|:|....|..:.||:.:...:|::.   |....|.|: ..:...:
  Rat   145 VAPQFLPRSLRVADLAANEVVEIFPLTFGEKPALRSVYLHNNRLRNTGLPPNTFHGS-EAITTLS 208

  Fly   159 FSHNALKQCDLPHMPL-LNRLELGHN---RLVNATFGVCPQLQELILNDNQLIQ--LDVNAFRGL 217
            .|.|.|:... |.:|. |.||.|.:|   ::......:..||:||.|..|||..  ||...|..|
  Rat   209 LSSNQLRYLP-PSLPASLERLHLQNNLISKVPRGALSLQTQLRELYLQHNQLTDSGLDATTFSKL 272

  Fly   218 HGLLELQLSGNRLSSI-----GLETFQPLAQ----------------LRKLNLSQNALDA----- 256
            ..|..|.||.|:|:::     |..|...|.:                ||.|.|..|.|:|
  Rat   273 SSLEYLDLSHNQLATVPEGLPGNLTILHLGRNCIRHVEAIRLHKAKGLRYLLLQHNKLEASALPA 337

  Fly   257 --LRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRV---LAR-LQMLDVSRNSIASLSPAHFV 315
              |||         :..|..|.|.|||:.       ||   |.| ||.|.:..|.:|:|.....|
  Rat   338 GTLRP---------LRALHTLHLYGNRLE-------RVPPALPRHLQALVMPHNRVAALGARDLV 386

  Fly   316 GLGSLRKLYLQYN--AILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLP-RMRRLNLNG 377
            ...:|.:|.|.||  |...:.|..|..|..|.:|||:.|.|..|.|      .|| .:|.|.|..
  Rat   387 SARALTELNLAYNRLASAHVHPGAFRRLRALRSLDLAGNQLSRLPE------GLPASLRSLRLQR 445

  Fly   378 NRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFA--PMRRLQKLHLGHNLLEEINLDVLESLS 440
            |:::.|.|...:.|..|..|.|.||.|:..|:...|  .::.||.|.|.||.|..:..|:.|:|
  Rat   446 NQLRTLEPEQLAGLNKLRELNLAHNRLRVGDIEPGAWHELQALQVLDLSHNELSFVPPDLPEAL- 509

  Fly   441 SVQEILVDNNRLTFLA-KVNVSFPNLKRVAIEGN 473
              :|:.:..||::.:. :..:|.|:|:.:::..|
  Rat   510 --EELYLQANRISHVGPEAFLSTPHLRALSLRAN 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	50/187 (27%)
		LRR_8	104..164	CDD:290566	15/67 (22%)
		leucine-rich repeat	106..129	CDD:275380	6/22 (27%)
		leucine-rich repeat	130..153	CDD:275380	5/25 (20%)
		leucine-rich repeat	154..195	CDD:275380	10/44 (23%)
		LRR_RI	194..455	CDD:238064	95/299 (32%)
		LRR_8	194..254	CDD:290566	26/82 (32%)
		leucine-rich repeat	196..219	CDD:275380	11/24 (46%)
		leucine-rich repeat	220..243	CDD:275380	9/27 (33%)
		leucine-rich repeat	244..267	CDD:275380	10/29 (34%)
		LRR_8	271..330	CDD:290566	22/64 (34%)
		leucine-rich repeat	272..295	CDD:275380	9/25 (36%)
		leucine-rich repeat	296..319	CDD:275380	7/22 (32%)
		LRR_8	319..380	CDD:290566	23/63 (37%)
		leucine-rich repeat	320..343	CDD:275380	9/24 (38%)
		leucine-rich repeat	344..369	CDD:275380	10/25 (40%)
		LRR_8	368..428	CDD:290566	22/62 (35%)
		leucine-rich repeat	370..393	CDD:275380	7/22 (32%)
		leucine-rich repeat	394..417	CDD:275380	8/24 (33%)
		leucine-rich repeat	418..441	CDD:275380	10/22 (45%)
Podnl1	XP_213845.6	leucine-rich repeat	64..82	CDD:275380	3/17 (18%)
		leucine-rich repeat	83..106	CDD:275380	3/22 (14%)
		LRR_8	84..143	CDD:290566	12/58 (21%)
		leucine-rich repeat	107..132	CDD:275380	4/24 (17%)
		leucine-rich repeat	133..177	CDD:275380	10/43 (23%)
		LRR_8	152..214	CDD:290566	14/62 (23%)
		LRR_RI	175..451	CDD:238064	87/299 (29%)
		leucine-rich repeat	178..203	CDD:275380	5/25 (20%)
		leucine-rich repeat	204..224	CDD:275380	5/20 (25%)
		LRR_8	224..285	CDD:290566	22/60 (37%)
		leucine-rich repeat	225..248	CDD:275380	5/22 (23%)
		leucine-rich repeat	249..274	CDD:275380	11/24 (46%)
		leucine-rich repeat	275..319	CDD:275380	9/43 (21%)
		LRR_8	295..356	CDD:290566	17/69 (25%)
		leucine-rich repeat	298..317	CDD:275380	1/18 (6%)
		leucine-rich repeat	320..345	CDD:275380	10/33 (30%)
		leucine-rich repeat	346..390	CDD:275380	17/50 (34%)
		LRR_8	365..427	CDD:290566	22/61 (36%)
		leucine-rich repeat	391..416	CDD:275380	9/24 (38%)
		leucine-rich repeat	417..440	CDD:275380	10/28 (36%)
		LRR_8	437..498	CDD:290566	21/60 (35%)
		leucine-rich repeat	441..461	CDD:275380	6/19 (32%)
		leucine-rich repeat	462..487	CDD:275380	8/24 (33%)
		LRR_8	488..543	CDD:290566	17/57 (30%)
		leucine-rich repeat	509..532	CDD:275380	5/25 (20%)
		leucine-rich repeat	533..556	CDD:275380	2/9 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910