DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and GP5

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_004479.1	Gene:	GP5 / 2814	HGNCID:	4443	Length:	560	Species:	Homo sapiens

Alignment Length:	425	Identity:	128/425 - (30%)
Similarity:	184/425 - (43%)	Gaps:	44/425 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 LP-NLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNALKQ 166
            || ||..:.|.|.|...::...|:..:.|||:..|.:.:..:....|.:|.||.....|.|.:..
Human    48 LPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITH 112

  Fly   167 CD---LPHMPLLNRLELGHN-----------RLVNATFGVCPQLQELILNDNQLIQLDVNAFRGL 217
            ..   |..|.||.:|.|.||           :|||        ||||.||.|||..|..:.|..|
Human   113 LPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVN--------LQELALNQNQLDFLPASLFTNL 169

  Fly   218 HGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQN---ALDALRPNVFGAVQNFVLHLQQLDLSG 279
            ..|..|.||||.|:.:........|:|.:|.|..|   :||:...|..||       |.:|....
Human   170 ENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGA-------LTELQFHR 227

  Fly   280 NRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNL 344
            |.||.:....|..|..|..|.:|||.:|.|..|.|:...:|..|.|..|.:.|:....|..:..|
Human   228 NHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGL 292

  Fly   345 DTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLN-GNRMKHLHPLAFSSLPFLEYLKLGHNELKSLD 408
            ..|.|:...|..|....|  ..|.|:|.|.:. ..|:..|...||..|..|:.|.|..|.|.:|.
Human   293 QELWLNRTQLRTLPAAAF--RNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALP 355

  Fly   409 VRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRL-TFLAKVNVSFPNLKRVAIEG 472
            ..:...:.:|:::.|..|.|..:...:..:|||::.:.:|:|:| |....|..:.|.|..|.:..
Human   356 DGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGH 420

  Fly   473 NPWQCPCFVKLQHWLATRDVVYLRDNTGYYKGERP 507
            |.|:|.|  .|..:|.     :||.:.|...||.|
Human   421 NSWRCDC--GLGPFLG-----WLRQHLGLVGGEEP 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	54/170 (32%)
		LRR_8	104..164	CDD:290566	17/60 (28%)
		leucine-rich repeat	106..129	CDD:275380	5/22 (23%)
		leucine-rich repeat	130..153	CDD:275380	6/22 (27%)
		leucine-rich repeat	154..195	CDD:275380	14/54 (26%)
		LRR_RI	194..455	CDD:238064	83/265 (31%)
		LRR_8	194..254	CDD:290566	24/62 (39%)
		leucine-rich repeat	196..219	CDD:275380	12/22 (55%)
		leucine-rich repeat	220..243	CDD:275380	7/22 (32%)
		leucine-rich repeat	244..267	CDD:275380	9/25 (36%)
		LRR_8	271..330	CDD:290566	20/58 (34%)
		leucine-rich repeat	272..295	CDD:275380	7/22 (32%)
		leucine-rich repeat	296..319	CDD:275380	9/22 (41%)
		LRR_8	319..380	CDD:290566	16/61 (26%)
		leucine-rich repeat	320..343	CDD:275380	6/22 (27%)
		leucine-rich repeat	344..369	CDD:275380	7/24 (29%)
		LRR_8	368..428	CDD:290566	17/60 (28%)
		leucine-rich repeat	370..393	CDD:275380	7/23 (30%)
		leucine-rich repeat	394..417	CDD:275380	6/22 (27%)
		leucine-rich repeat	418..441	CDD:275380	5/22 (23%)
GP5	NP_004479.1	LRR 1	75..96		5/20 (25%)
		LRR_RI	<76..230	CDD:238064	53/168 (32%)
		LRR_8	76..134	CDD:290566	18/57 (32%)
		leucine-rich repeat	76..99	CDD:275380	6/22 (27%)
		LRR 2	99..120		5/20 (25%)
		leucine-rich repeat	100..123	CDD:275380	5/22 (23%)
		LRR 3	123..144		6/20 (30%)
		leucine-rich repeat	124..147	CDD:275380	6/22 (27%)
		LRR_8	147..206	CDD:290566	25/66 (38%)
		LRR 4	147..168		12/28 (43%)
		leucine-rich repeat	148..171	CDD:275380	12/22 (55%)
		LRR_RI	163..400	CDD:238064	71/245 (29%)
		LRR 5	171..193		7/21 (33%)
		leucine-rich repeat	172..195	CDD:275380	7/22 (32%)
		LRR_8	195..254	CDD:290566	21/65 (32%)
		LRR 6	195..216		6/20 (30%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		LRR 7	219..240		7/27 (26%)
		leucine-rich repeat	220..243	CDD:275380	7/22 (32%)
		LRR_8	242..302	CDD:290566	18/59 (31%)
		LRR 8	243..264		9/20 (45%)
		leucine-rich repeat	244..267	CDD:275380	9/22 (41%)
		LRR 9	267..288		6/20 (30%)
		leucine-rich repeat	268..291	CDD:275380	6/22 (27%)
		LRR 10	291..312		6/22 (27%)
		leucine-rich repeat	292..315	CDD:275380	7/24 (29%)
		LRR_8	314..375	CDD:290566	17/60 (28%)
		leucine-rich repeat	316..338	CDD:275380	6/21 (29%)
		LRR 11	340..361		6/20 (30%)
		leucine-rich repeat	341..364	CDD:275380	6/22 (27%)
		LRR_8	364..421	CDD:290566	15/56 (27%)
		LRR 12	364..385		4/20 (20%)
		leucine-rich repeat	365..388	CDD:275380	5/22 (23%)
		LRR 13	388..409		6/20 (30%)
		leucine-rich repeat	389..410	CDD:275380	5/20 (25%)
		LRRCT	421..472	CDD:214507	12/35 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	469..498
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910