DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6749 and Lrrc4b

DIOPT Version :9

Sequence 1:NP_648354.1 Gene:CG6749 / 39144 FlyBaseID:FBgn0036040 Length:552 Species:Drosophila melanogaster
Sequence 2:NP_937893.1 Gene:Lrrc4b / 272381 MGIID:3027390 Length:709 Species:Mus musculus


Alignment Length:376 Identity:107/376 - (28%)
Similarity:159/376 - (42%) Gaps:91/376 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   189 TFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNA 253
            ||.....|:.|.|:.|.:.:::|.||.||..|..|:|..|||:::..:.|:.|::||:|.|..|.
Mouse   107 TFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNP 171

  Fly   254 LDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLG 318
            ::::....|    |.|..|::|||.             .|.||:.          :|.|.|.||.
Mouse   172 IESIPSYAF----NRVPSLRRLDLG-------------ELKRLEY----------ISEAAFEGLV 209

  Fly   319 SLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHL 383
            :||.|.|....:.:|...|  ||:.|:.|:||.|.|:.:....|.|  |..:|:|.|...::..:
Mouse   210 NLRYLNLGMCNLKDIPNLT--ALVRLEELELSGNRLDLIRPGSFQG--LTSLRKLWLMHAQVATI 270

  Fly   384 HPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVL-------ESLSS 441
            ...||..|..||.|.|.||.|.||...:|.|:.||:::||.||.. ..|.|||       |::.|
Mouse   271 ERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPW-HCNCDVLWLSWWLKETVPS 334

  Fly   442 ------------------VQEILVDNNRLTFLAKVNVSFPNLKRVAIEGNPWQCPC----FVKLQ 484
                              :.|:  |.:..|..|.|.|..|....|. ||...:..|    .:...
Mouse   335 NTTCCARCHAPAGLKGRYIGEL--DQSHFTCYAPVIVEPPTDLNVT-EGMAAELKCRTGTSMTSV 396

  Fly   485 HWLATRD-----------VVYLRD-----------NTGYYKGERPLCIVTN 513
            :||....           :..|.|           :||.|     .|:|||
Mouse   397 NWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQY-----TCMVTN 442

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6749NP_648354.1 LRR_RI 103..>256 CDD:238064 24/66 (36%)
LRR_8 104..164 CDD:290566
leucine-rich repeat 106..129 CDD:275380
leucine-rich repeat 130..153 CDD:275380
leucine-rich repeat 154..195 CDD:275380 2/5 (40%)
LRR_RI 194..455 CDD:238064 86/285 (30%)
LRR_8 194..254 CDD:290566 22/59 (37%)
leucine-rich repeat 196..219 CDD:275380 9/22 (41%)
leucine-rich repeat 220..243 CDD:275380 8/22 (36%)
leucine-rich repeat 244..267 CDD:275380 6/22 (27%)
LRR_8 271..330 CDD:290566 16/58 (28%)
leucine-rich repeat 272..295 CDD:275380 5/22 (23%)
leucine-rich repeat 296..319 CDD:275380 6/22 (27%)
LRR_8 319..380 CDD:290566 20/60 (33%)
leucine-rich repeat 320..343 CDD:275380 8/22 (36%)
leucine-rich repeat 344..369 CDD:275380 9/24 (38%)
LRR_8 368..428 CDD:290566 23/59 (39%)
leucine-rich repeat 370..393 CDD:275380 6/22 (27%)
leucine-rich repeat 394..417 CDD:275380 11/22 (50%)
leucine-rich repeat 418..441 CDD:275380 10/29 (34%)
Lrrc4bNP_937893.1 LRRNT 59..92 CDD:214470
LRR <89..299 CDD:227223 71/222 (32%)
LRR 1 89..110 2/2 (100%)
leucine-rich repeat 90..113 CDD:275380 2/5 (40%)
LRR 2 113..134 7/20 (35%)
leucine-rich repeat 114..137 CDD:275380 9/22 (41%)
LRR 3 137..158 7/20 (35%)
leucine-rich repeat 138..161 CDD:275380 8/22 (36%)
LRR 4 161..182 6/24 (25%)
leucine-rich repeat 162..185 CDD:275380 8/26 (31%)
LRR 5 185..207 10/44 (23%)
leucine-rich repeat 186..210 CDD:275380 12/46 (26%)
LRR 6 210..231 7/22 (32%)
leucine-rich repeat 211..232 CDD:275380 8/22 (36%)
LRR 7 232..253 7/20 (35%)
leucine-rich repeat 233..256 CDD:275380 9/24 (38%)
LRR 8 256..277 5/20 (25%)
leucine-rich repeat 257..280 CDD:275380 6/22 (27%)
LRR 9 280..301 10/20 (50%)
leucine-rich repeat 281..302 CDD:275380 10/20 (50%)
LRRCT 313..363 CDD:214507 9/52 (17%)
I-set 366..455 CDD:400151 18/83 (22%)
Ig strand A 366..369 CDD:409353 1/2 (50%)
Ig strand A' 373..376 CDD:409353 0/2 (0%)
Ig strand B 382..389 CDD:409353 1/6 (17%)
Ig strand C 395..400 CDD:409353 1/4 (25%)
Ig strand C' 403..405 CDD:409353 0/1 (0%)
Ig strand D 414..418 CDD:409353 0/3 (0%)
Ig strand E 421..425 CDD:409353 0/3 (0%)
Ig strand F 435..442 CDD:409353 3/11 (27%)
Ig strand G 445..455 CDD:409353
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..552
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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