DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6749 and LRRC57

DIOPT Version :9

Sequence 1:NP_648354.1 Gene:CG6749 / 39144 FlyBaseID:FBgn0036040 Length:552 Species:Drosophila melanogaster
Sequence 2:NP_694992.2 Gene:LRRC57 / 255252 HGNCID:26719 Length:239 Species:Homo sapiens


Alignment Length:285 Identity:67/285 - (23%)
Similarity:117/285 - (41%) Gaps:83/285 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   219 GLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIR 283
            ||.|......:|:|          .||.::||.|.:::|.|.:.|   .|.| |:.|.|:.|::.
Human    25 GLTEFPADLQKLTS----------NLRTIDLSNNKIESLPPLLIG---KFTL-LKSLSLNNNKLT 75

  Fly   284 LLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLD 348
            :|.| :...|.:|:.|.::.|.:..| |:.|..|.:|:.|.|..|. |...|....:|.:||.:|
Human    76 VLPD-EICNLKKLETLSLNNNHLREL-PSTFGQLSALKTLSLSGNQ-LGALPPQLCSLRHLDVMD 137

  Fly   349 LSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFA 413
            ||.|.:..:.:.:                           ..|..:| |.|..|::..:.|:: :
Human   138 LSKNQIRSIPDSV---------------------------GELQVIE-LNLNQNQISQISVKI-S 173

  Fly   414 PMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLAKVNVSFPNLKRVAIEGNPWQCP 478
            ...||:.|.|..|.||         ||.:.:.::.::::..|             |:|||.:   
Human   174 CCPRLKILRLEENCLE---------LSMLPQSILSDSQICLL-------------AVEGNLF--- 213

  Fly   479 CFVKLQHWLATRDVVYLRDNTGYYK 503
                        ::..||:..||.|
Human   214 ------------EIKKLRELEGYDK 226

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6749NP_648354.1 LRR_RI 103..>256 CDD:238064 10/36 (28%)
LRR_8 104..164 CDD:290566
leucine-rich repeat 106..129 CDD:275380
leucine-rich repeat 130..153 CDD:275380
leucine-rich repeat 154..195 CDD:275380
LRR_RI 194..455 CDD:238064 57/235 (24%)
LRR_8 194..254 CDD:290566 10/34 (29%)
leucine-rich repeat 196..219 CDD:275380 67/285 (24%)
leucine-rich repeat 220..243 CDD:275380 4/22 (18%)
leucine-rich repeat 244..267 CDD:275380 8/22 (36%)
LRR_8 271..330 CDD:290566 18/58 (31%)
leucine-rich repeat 272..295 CDD:275380 7/22 (32%)
leucine-rich repeat 296..319 CDD:275380 7/22 (32%)
LRR_8 319..380 CDD:290566 13/60 (22%)
leucine-rich repeat 320..343 CDD:275380 7/22 (32%)
leucine-rich repeat 344..369 CDD:275380 6/24 (25%)
LRR_8 368..428 CDD:290566 11/59 (19%)
leucine-rich repeat 370..393 CDD:275380 1/22 (5%)
leucine-rich repeat 394..417 CDD:275380 5/22 (23%)
leucine-rich repeat 418..441 CDD:275380 7/22 (32%)
LRRC57NP_694992.2 PRK15370 <21..>211 CDD:185268 60/253 (24%)
LRR 1 39..60 8/23 (35%)
leucine-rich repeat 40..63 CDD:275380 9/25 (36%)
LRR 2 63..84 7/22 (32%)
leucine-rich repeat 64..86 CDD:275380 7/22 (32%)
LRR 3 86..107 6/21 (29%)
leucine-rich repeat 87..109 CDD:275380 7/22 (32%)
LRR 4 109..131 6/22 (27%)
leucine-rich repeat 110..132 CDD:275380 7/22 (32%)
LRR 5 132..153 6/47 (13%)
leucine-rich repeat 133..154 CDD:275380 6/47 (13%)
LRR 6 154..175 5/22 (23%)
leucine-rich repeat 155..177 CDD:275380 5/23 (22%)
LRR 7 177..197 9/28 (32%)
leucine-rich repeat 178..199 CDD:275380 8/29 (28%)
LRR 8 202..222 7/47 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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