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Protein Alignment CG6749 and Lrrc8a

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_808393.1	Gene:	Lrrc8a / 241296	MGIID:	2652847	Length:	810	Species:	Mus musculus

Alignment Length:	505	Identity:	137/505 - (27%)
Similarity:	215/505 - (42%)	Gaps:	106/505 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ILHGADLCQPIGWRNFQ--CSEVASLQDLVDLGAENWHTL------AIRNVQTELEVG----SGE 74
            :||..|...|:..:.|.  .||| |...|..|...|..||      ..:|.|.:||:.    ||
Mouse   375 MLHLIDQYDPLYSKRFAVFLSEV-SENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLSG- 437

  Fly    75 NADHLANLLDLDLTGAAPINVHTNGFSILPNLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQ 139
            ..|.:.:|::|::.....|    ...:|.|::.||.    ||.::...|.|.:.....:.|...
Mouse   438 IPDTVFDLVELEVLKLELI----PDVTIPPSIAQLT----GLKELWLYHTAAKIEAPALAFLRE- 493

  Fly   140 MELLDRDFFGNLRKLIYANFSHNALKQCDLPHMPL-------LNRLEL-GHNRLVNATFGVCPQL 196
                      |||.|      |  :|..|:..:||       |..|.| |:....|..:.|...|
Mouse   494 ----------NLRAL------H--IKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGL 540

  Fly   197 QEL----IL----NDNQLIQL--DVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQ 251
            :||    :|    |.::|.|:  ||    |:| |.:|.::......|.|.:.:.:..|.:|.|.:
Mouse   541 RELKRLKVLRLKSNLSKLPQVVTDV----GVH-LQKLSINNEGTKLIVLNSLKKMVNLTELELIR 600

  Fly   252 NALDALRPNVFGAVQNFVLH-LQQLDLSGNRIRLLFD-NQFRVLARLQMLDVSRNSIASLSPAHF 314
            ..|:.:..::|.      || ||::||..|.::.:.: ..|:.|.||..|.:..|.||.: |...
Mouse   601 CDLERIPHSIFS------LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYI-PIQI 658

  Fly   315 VGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNR 379
            ..|.:|.:|||..|.|.:| |........|..||||:|||.||...|   ..|..::.|.:..||
Mouse   659 GNLTNLERLYLNRNKIEKI-PTQLFYCRKLRYLDLSHNNLTFLPADI---GLLQNLQNLAVTANR 719

  Fly   380 MKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQE 444
            ::.|.|..|.                         .|:|:.||||:|:|:.:...|.| |:::.:
Mouse   720 IEALPPELFQ-------------------------CRKLRALHLGNNVLQSLPSRVGE-LTNLTQ 758

  Fly   445 ILVDNNRLTFLAKVNVSFPNLKR--VAIEGNPWQ-CPCFVKLQHWLATRD 491
            |.:..|||..|.......|.|||  :.:|.:.:. .|..||.:.|.|.::
Mouse   759 IELRGNRLECLPVELGECPLLKRSGLVVEEDLFSTLPPEVKERLWRADKE 808

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.