DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and Lrrk1

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_006540901.1	Gene:	Lrrk1 / 233328	MGIID:	2142227	Length:	2015	Species:	Mus musculus

Alignment Length:	510	Identity:	132/510 - (25%)
Similarity:	205/510 - (40%)	Gaps:	152/510 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 NWHTLAIRNVQTELEVGSGENADHLANLLDLDLTGAAPIN--VHTNGFSILPNLRQLNLSGCGLV 117
            || .||:...:..|||         ..||.| ..||.|.|  |..|.|.::..|........|..
Mouse   155 NW-MLALACQRGHLEV---------VKLLVL-THGADPENYAVRKNEFPVIVRLPLYAAIKAGNE 208

  Fly   118 DI------RGNHF-------APE-------------SALQ---------RIDFSHNQMELLDRDF 147
            ||      .|.:|       :||             |||.         |:.:||.::..:|.|:
Mouse   209 DIAIFLLRHGAYFCSYILLDSPEPSKHLLRKYFIEASALPSSYPGKIALRVKWSHLKLPWVDLDW 273

  Fly   148 FGNLR-KLIYANFSHNALKQCDLPHMPLLNRLELGHNRLVNATFGVCPQLQELILNDNQLIQL-- 209
            ..::. ::...:.|.|.     ||.:|.:  :..|   |:|        |::|.|::|||.:|
Mouse   274 LLDISCQITELDLSANC-----LPSLPSI--IPWG---LIN--------LKKLNLSNNQLGELPC 320

  Fly   210 -----DVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDAL-----RPNVFGA 264
                 ::...|    |||:.:|.|:||.:. ..|..|::|:||..|:|.|:.|     ..|..|
Mouse   321 VQSSDEIICSR----LLEIDISSNKLSHLP-PGFLHLSKLQKLTASKNYLERLFEEENATNWIG- 379

  Fly   265 VQNFVLHLQQLDLSGNRIRLL---FDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQ 326
                :..||:|||:.||:..|   |.:.|:   .|..|:||||::.|........|...:   ..
Mouse   380 ----LRKLQELDLADNRLTELPVQFMHSFK---SLTSLNVSRNNLKSFPDPWSCPLKCCK---AS 434

  Fly   327 YNAILEIKPATFAAL--LNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFS 389
            .|| ||..|...|..  .:|...|.|.|:|:.:...:|   .|..:..|.|.||::..|.|....
Mouse   435 KNA-LESLPDKMAVFWKSHLRDADFSENSLKEVPLGLF---QLDALMFLRLQGNQLLSLPPQEKW 495

  Fly   390 SLPFLEYL-----KLGHNE--LKSLDVRMFAPMRR--------------------LQKLHLGHNL 427
            :...|:.|     :||.||  ||:..:.:|....|                    |:.|.|..|.
Mouse   496 TCTQLKTLDLSRNQLGKNEDGLKTKRISLFTTRGRQRSGTETASMLEFPAFLSESLEVLCLNDNH 560

  Fly   428 LEEI--NLDVLESLSSVQEILVDNNRLTFLAKVNVSFPNLKRVAIE----GNPWQ 476
            |:.:  ::.:|::||   |:.:.||            |.|:.:..|    ||.||
Mouse   561 LDAVPPSVCLLKNLS---ELYLGNN------------PGLRELPPELGQLGNLWQ 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	47/195 (24%)
		LRR_8	104..164	CDD:290566	18/95 (19%)
		leucine-rich repeat	106..129	CDD:275380	8/48 (17%)
		leucine-rich repeat	130..153	CDD:275380	6/32 (19%)
		leucine-rich repeat	154..195	CDD:275380	8/40 (20%)
		LRR_RI	194..455	CDD:238064	84/306 (27%)
		LRR_8	194..254	CDD:290566	22/66 (33%)
		leucine-rich repeat	196..219	CDD:275380	8/29 (28%)
		leucine-rich repeat	220..243	CDD:275380	9/22 (41%)
		leucine-rich repeat	244..267	CDD:275380	9/27 (33%)
		LRR_8	271..330	CDD:290566	19/61 (31%)
		leucine-rich repeat	272..295	CDD:275380	10/25 (40%)
		leucine-rich repeat	296..319	CDD:275380	8/22 (36%)
		LRR_8	319..380	CDD:290566	17/62 (27%)
		leucine-rich repeat	320..343	CDD:275380	6/24 (25%)
		leucine-rich repeat	344..369	CDD:275380	7/24 (29%)
		LRR_8	368..428	CDD:290566	20/86 (23%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	9/29 (31%)
		leucine-rich repeat	418..441	CDD:275380	7/24 (29%)
Lrrk1	XP_006540901.1	Ank_2	59..143	CDD:372319
		ANK repeat	92..120	CDD:293786
		Ank_2	127..219	CDD:372319	21/74 (28%)
		ANK repeat	149..187	CDD:293786	14/42 (33%)
		ANK repeat	189..219	CDD:293786	6/29 (21%)
		LRR	<280..514	CDD:227223	75/271 (28%)
		leucine-rich repeat	282..304	CDD:275380	7/31 (23%)
		leucine-rich repeat	305..331	CDD:275380	7/25 (28%)
		leucine-rich repeat	332..382	CDD:275380	18/55 (33%)
		leucine-rich repeat	355..378	CDD:275380	8/22 (36%)
		leucine-rich repeat	383..406	CDD:275380	10/25 (40%)
		leucine-rich repeat	407..452	CDD:275380	14/48 (29%)
		leucine-rich repeat	453..475	CDD:275380	7/24 (29%)
		leucine-rich repeat	476..499	CDD:275380	6/22 (27%)
		leucine-rich repeat	500..550	CDD:275380	10/49 (20%)
		leucine-rich repeat	551..573	CDD:275380	6/21 (29%)
		P-loop_NTPase	640..822	CDD:393306
		COR	845..1037	CDD:379765
		STKc_LRRK1	1249..1524	CDD:270969
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910