DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6749 and PHLPP1

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_919431.2	Gene:	PHLPP1 / 23239	HGNCID:	20610	Length:	1717	Species:	Homo sapiens

Alignment Length:	640	Identity:	120/640 - (18%)
Similarity:	214/640 - (33%)	Gaps:	226/640 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 LRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQME----------LLDRDFFGNLRKLIYANFS 160
            :..::||.|.|..:..|.|..:. |..::...|.:.          |.:...|..|:.|   |.|
Human   639 ISSVDLSCCSLEHLPANLFYSQD-LTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSL---NLS 699

  Fly   161 HN-----ALKQCDLPHMPLLNRLELGHNRLVNATFGVCPQLQELILNDNQL-------------- 206
            :|     .|..|.:|.:..|| :.....|.|.|..||...||..:|:.|.|
Human   700 NNHLGDFPLAVCSIPTLAELN-VSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLS 763

  Fly   207 -IQLDVNAFRGLHGLLE-------LQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFG 263
             :.|..|.|..:..:||       |.:|||.:.::.|:..:.:..::.::|   .|:.:|..:..
Human   764 YLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDL---RLNVIRKLIAD 825

  Fly   264 AVQNFVLHLQQLDLSGNRI----RLLFDNQFRVL------------------------------- 293
            .| :|:.|:.||||..|::    .::|:| ..||
Human   826 EV-DFLQHVTQLDLRDNKLGDLDAMIFNN-IEVLHCERNQLVTLDICGYFLKALYASSNELVQLD 888

  Fly   294 ----------------------------ARLQMLDVSRNSIASLSPAHFVGLGSLRKLY------ 324
                                        .:|::||:..|.|..| ||......|||||.
Human   889 VYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICEL-PARLFCNSSLRKLLAGHNQL 952

  Fly   325 ----------------LQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRL 373
                            :|:|.:||:.|.......:|..|:.|.|.||.|........|...::.|
Human   953 ARLPERLERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQEL 1017

  Fly   374 NLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLE- 437
            .|..|.:........:..|.|:.|.:.:|.|:|......|.:..|:::.|..|.|:.|...::.
Human  1018 YLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNC 1082

  Fly   438 -------SLSSVQEILVDNNRLTFLAKVNVSF-------------PNLKRVAIEGNP-------- 474
                   :.|:..|:..:..:|..:..|::|.             |.|:.:.:.|||
Human  1083 RRMHTVIAHSNCIEVFPEVMQLPEIKCVDLSCNELSEVTLPENLPPKLQELDLTGNPRLVLDHKT 1147

  Fly   475 --------------------------WQ-------------CPCFVKLQHWLATRDVVYLRDNTG 500
                                      |.             |...:.:.::...|:.:|     |
Human  1148 LELLNNIRCFKIDQPSTGDASGAPAVWSHGYTEASGVKNKLCVAALSVNNFCDNREALY-----G 1207

  Fly   501 YYKGERPL-------CIVTNV------------DYCIQNLQAV-RRLGILGDFQG 535
            .:.|:|.:       |.::::            :|.:.....: |:||..|...|
Human  1208 VFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTAGQKLG 1262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	42/186 (23%)
		LRR_8	104..164	CDD:290566	15/72 (21%)
		leucine-rich repeat	106..129	CDD:275380	6/22 (27%)
		leucine-rich repeat	130..153	CDD:275380	5/32 (16%)
		leucine-rich repeat	154..195	CDD:275380	14/45 (31%)
		LRR_RI	194..455	CDD:238064	74/375 (20%)
		LRR_8	194..254	CDD:290566	16/81 (20%)
		leucine-rich repeat	196..219	CDD:275380	8/37 (22%)
		leucine-rich repeat	220..243	CDD:275380	7/29 (24%)
		leucine-rich repeat	244..267	CDD:275380	4/22 (18%)
		LRR_8	271..330	CDD:290566	25/143 (17%)
		leucine-rich repeat	272..295	CDD:275380	9/85 (11%)
		leucine-rich repeat	296..319	CDD:275380	8/22 (36%)
		LRR_8	319..380	CDD:290566	21/82 (26%)
		leucine-rich repeat	320..343	CDD:275380	9/44 (20%)
		leucine-rich repeat	344..369	CDD:275380	8/24 (33%)
		LRR_8	368..428	CDD:290566	13/59 (22%)
		leucine-rich repeat	370..393	CDD:275380	3/22 (14%)
		leucine-rich repeat	394..417	CDD:275380	6/22 (27%)
		leucine-rich repeat	418..441	CDD:275380	5/30 (17%)
PHLPP1	NP_919431.2	leucine-rich repeat	1107..1129	CDD:275380	2/21 (10%)
		PP2Cc	1168..1420	CDD:214625	14/100 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1458..1510
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1673..1717
		PDZ-binding, required for interaction with SLC9A3R1. /evidence=ECO:0000269\|PubMed:21804599	1715..1717
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..118
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..156
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..470
		PH_PHLPP-like	535..631	CDD:270131
		PH	555..636	CDD:278594
		LRR_RI	625..929	CDD:238064	59/299 (20%)
		LRR_8	638..703	CDD:290566	15/67 (22%)
		LRR 1	638..659		6/19 (32%)
		leucine-rich repeat	641..661	CDD:275380	6/19 (32%)
		LRR 2	661..682		2/21 (10%)
		leucine-rich repeat	662..692	CDD:275380	4/29 (14%)
		LRR 3	692..712		6/22 (27%)
		leucine-rich repeat	693..738	CDD:275380	15/48 (31%)
		LRR_8	714..770	CDD:290566	14/56 (25%)
		LRR 4	715..736		6/21 (29%)
		LRR 5	738..760		5/21 (24%)
		leucine-rich repeat	739..761	CDD:275380	5/21 (24%)
		LRR 6	761..783		5/21 (24%)
		leucine-rich repeat	762..784	CDD:275380	5/21 (24%)
		LRR 7	784..804		5/19 (26%)
		leucine-rich repeat	785..808	CDD:275380	5/22 (23%)
		LRR 8	808..831		5/26 (19%)
		leucine-rich repeat	810..832	CDD:275380	5/25 (20%)
		LRR_RI	814..1074	CDD:238064	55/265 (21%)
		LRR 9	832..853		7/20 (35%)
		leucine-rich repeat	833..853	CDD:275380	6/19 (32%)
		leucine-rich repeat	854..895	CDD:275380	2/40 (5%)
		LRR 10	873..894		0/20 (0%)
		LRR 11	895..916		0/20 (0%)
		leucine-rich repeat	896..918	CDD:275380	0/21 (0%)
		LRR 12	918..939		8/21 (38%)
		leucine-rich repeat	919..941	CDD:275380	8/22 (36%)
		LRR 13	941..962		5/20 (25%)
		leucine-rich repeat	942..963	CDD:275380	4/20 (20%)
		LRR_8	962..1024	CDD:290566	16/61 (26%)
		LRR 14	963..984		5/20 (25%)
		leucine-rich repeat	964..987	CDD:275380	5/22 (23%)
		LRR 15	987..1008		7/20 (35%)
		leucine-rich repeat	988..1011	CDD:275380	7/22 (32%)
		LRR 16	1013..1033		3/19 (16%)
		LRR_8	1014..1072	CDD:290566	13/57 (23%)
		leucine-rich repeat	1014..1037	CDD:275380	3/22 (14%)
		LRR 17	1037..1058		5/20 (25%)
		leucine-rich repeat	1038..1061	CDD:275380	6/22 (27%)
		LRR 18	1061..1082		5/20 (25%)
		Interaction with SLC9A3R1. /evidence=ECO:0000269\|PubMed:21804599	1076..1205		13/128 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910