DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and FLII

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_005256612.1	Gene:	FLII / 2314	HGNCID:	3750	Length:	1296	Species:	Homo sapiens

Alignment Length:	471	Identity:	123/471 - (26%)
Similarity:	209/471 - (44%)	Gaps:	108/471 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 LDLTGAAP----INVHTNGF---------SILPNLRQLNLSGCGLVDIRGNHFAPE--SALQRID 134
            ::.||..|    :::..|.|         ..:.:||.|.|:..||.      :.||  :|||:::
Human     1 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLC------YLPEELAALQKLE 59

  Fly   135 ---FSHNQMELLDRDF--FGNLRKLIYANFSHNALKQCDLP----HMPLLNRLELGHNRLVNATF 190
               .|||.:..|..:.  ..:||.::   ...|:||...:|    .:..|:.|:|.||:|..
Human    60 HLSVSHNNLTTLHGELSSLPSLRAIV---ARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTE--- 118

  Fly   191 GVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALD 255
              ||:..|...|                 :|.|.||.|.:.:|..:.|..|..|..|:||:|.|:
Human   119 --CPRELENAKN-----------------MLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLE 164

  Fly   256 ALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSL 320
            :|.|.:     ..::|||.|.|:||.:         :.|:|:.|           ||    :.:|
Human   165 SLPPQM-----RRLVHLQTLVLNGNPL---------LHAQLRQL-----------PA----MTAL 200

  Fly   321 RKLYLQYNAILEIK-PATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLH 384
            :.|:|:.....:.. |.:...|.||..:|||.|:|..:.|.::   |||.:|||||:.|::..|
Human   201 QTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLY---TLPSLRRLNLSSNQITEL- 261

  Fly   385 PLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLES----LSSVQEI 445
            .|.......:|.|.|..|:|.||. .....:.:|:||:|..|   :::.|.|.|    |::::|.
Human   262 SLCIDQWVHVETLNLSRNQLTSLP-SAICKLSKLKKLYLNSN---KLDFDGLPSGIGKLTNLEEF 322

  Fly   446 LVDNNRLTFLAKVNVSFPNLKRVAIEGNPWQCPCFVKLQ---HWLATRDVVYLRDNTGYYKGERP 507
            :..||.|..:.:.....|.|:::.:..|.     .|.|.   |:|...:|:.:|:|.......:|
Human   323 MAANNNLELVPESLCRCPKLRKLVLNKNH-----LVTLPEAIHFLTEIEVLDVRENPNLVMPPKP 382

  Fly   508 LCIVT---NVDYCIQN 520
            .....   |:|:.:||
Human   383 ADRAAEWYNIDFSLQN 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	45/163 (28%)
		LRR_8	104..164	CDD:290566	18/66 (27%)
		leucine-rich repeat	106..129	CDD:275380	8/24 (33%)
		leucine-rich repeat	130..153	CDD:275380	7/27 (26%)
		leucine-rich repeat	154..195	CDD:275380	11/44 (25%)
		LRR_RI	194..455	CDD:238064	75/265 (28%)
		LRR_8	194..254	CDD:290566	16/59 (27%)
		leucine-rich repeat	196..219	CDD:275380	2/22 (9%)
		leucine-rich repeat	220..243	CDD:275380	8/22 (36%)
		leucine-rich repeat	244..267	CDD:275380	8/22 (36%)
		LRR_8	271..330	CDD:290566	15/58 (26%)
		leucine-rich repeat	272..295	CDD:275380	6/22 (27%)
		leucine-rich repeat	296..319	CDD:275380	4/22 (18%)
		LRR_8	319..380	CDD:290566	22/61 (36%)
		leucine-rich repeat	320..343	CDD:275380	5/23 (22%)
		leucine-rich repeat	344..369	CDD:275380	9/24 (38%)
		LRR_8	368..428	CDD:290566	21/59 (36%)
		leucine-rich repeat	370..393	CDD:275380	8/22 (36%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..441	CDD:275380	9/26 (35%)
FLII	XP_005256612.1	LRR_RI	<2..139	CDD:238064	41/167 (25%)
		leucine-rich repeat	10..34	CDD:275380	2/23 (9%)
		LRR_8	33..91	CDD:290566	18/66 (27%)
		leucine-rich repeat	35..57	CDD:275380	10/27 (37%)
		leucine-rich repeat	58..80	CDD:275380	4/21 (19%)
		leucine-rich repeat	83..105	CDD:275378	4/24 (17%)
		LRR_RI	89..374	CDD:238064	95/348 (27%)
		leucine-rich repeat	106..128	CDD:275380	9/26 (35%)
		leucine-rich repeat	129..152	CDD:275380	8/22 (36%)
		LRR_8	131..186	CDD:290566	22/59 (37%)
		leucine-rich repeat	153..175	CDD:275380	8/26 (31%)
		leucine-rich repeat	176..199	CDD:275380	11/46 (24%)
		leucine-rich repeat	200..224	CDD:275380	5/23 (22%)
		LRR_8	223..281	CDD:290566	23/61 (38%)
		leucine-rich repeat	225..247	CDD:275380	9/24 (38%)
		leucine-rich repeat	248..270	CDD:275380	8/22 (36%)
		leucine-rich repeat	271..293	CDD:275380	7/22 (32%)
		leucine-rich repeat	294..318	CDD:275380	9/26 (35%)
		leucine-rich repeat	319..339	CDD:275380	4/19 (21%)
		leucine-rich repeat	342..355	CDD:275378	3/17 (18%)
		gelsolin_S1_like	492..604	CDD:200446
		gelsolin_like	619..706	CDD:200436
		gelsolin_S3_like	723..837	CDD:200448
		gelsolin_like	<974..1034	CDD:200436
		gelsolin_S5_like	1053..1152	CDD:200444
		gelsolin_S6_like	1163..1289	CDD:200447
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910