DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and phlp-2

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001337270.1	Gene:	phlp-2 / 185690	WormBaseID:	WBGene00009647	Length:	1126	Species:	Caenorhabditis elegans

Alignment Length:	501	Identity:	116/501 - (23%)
Similarity:	180/501 - (35%)	Gaps:	164/501 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 PNLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNAL---- 164
            ||:.:..|:....|: :.||         :|.|..|:.|:......|..::...|...|:|
Worm   214 PNILEAWLTRAQQVE-KSNH---------VDASDEQLTLIPEQILNNEARVQILNLRRNSLISRP 268

  Fly   165 ----KQCDLPHMPLLNRLELGHNRLVNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQL 225
                ....|.::..|.|:.               .||.:.|:.||::...:......| |.:|.|
Worm   269 PTEKSMAPLGYIDDLYRVH---------------SLQVIDLSANQILSFPIQLTLLSH-LRQLNL 317

  Fly   226 SGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQN------------------FVLHL 272
            |.|.:||:..|. ..:.:|:.||||.|.||.| |:....:||                  |.|.|
Worm   318 SSNYISSVPSEC-SNMRRLQYLNLSNNQLDTL-PDSISELQNLQSLDISFNQFSQIPPCLFHLTL 380

  Fly   273 QQLDLSGNRI-----------------RLLFDNQFRV-LARLQMLDVSRNSIAS----------- 308
            :...|:||.|                 |.:.|..||: :..:..||:..||:.|
Worm   381 EMWRLAGNNIEKIDRVGEMQIQKIDLRRNVLDTSFRLDIENITHLDLRDNSMISTVHLTNLRFLK 445

  Fly   309 --------LSPAHFVGLGSLRKLYLQYNAI--LEIKPATFAALLNLDTLDLSYN----------- 352
                    ||..|..| .||..:|..:|.:  |.:.|..    .||.||.||:|
Worm   446 VIHCERLQLSSLHLSG-ESLTHVYADHNLLDSLVVMPLP----QNLQTLSLSFNHFRNLPDWISD 505

  Fly   353 --NLEFLE----------EQIFGGNT--------------------------------------- 366
              ||.||.          |:||...:
Worm   506 CPNLTFLRANNNSLVALPERIFYSQSLRSIFAFINEIEHIPDFGEENCLETLILYKNKLSSLPKH 570

  Fly   367 ----LPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNL 427
                |||:|:||::.|.::.|.....||...|:.|:..:|.|....|.:...|:.|:.:.|.||.
Worm   571 FFSILPRLRQLNISSNFIELLPYFDGSSFCRLQILRCANNYLTENSVPVIVNMKHLKIIDLSHNR 635

  Fly   428 LEEINLDVLESLSSVQEILVDNNRLTFLAKVNVSFPNLKRVAIEGN 473
            |...:...|.||..::::.:.:||||.||......|.|:.:....|
Worm   636 LNSFDDSALSSLELLEDLNLSSNRLTRLADCLALLPCLQVLRAHSN 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	38/159 (24%)
		LRR_8	104..164	CDD:290566	13/59 (22%)
		leucine-rich repeat	106..129	CDD:275380	4/22 (18%)
		leucine-rich repeat	130..153	CDD:275380	5/22 (23%)
		leucine-rich repeat	154..195	CDD:275380	6/48 (13%)
		LRR_RI	194..455	CDD:238064	94/383 (25%)
		LRR_8	194..254	CDD:290566	20/59 (34%)
		leucine-rich repeat	196..219	CDD:275380	5/22 (23%)
		leucine-rich repeat	220..243	CDD:275380	8/22 (36%)
		leucine-rich repeat	244..267	CDD:275380	10/22 (45%)
		LRR_8	271..330	CDD:290566	22/95 (23%)
		leucine-rich repeat	272..295	CDD:275380	9/40 (23%)
		leucine-rich repeat	296..319	CDD:275380	9/41 (22%)
		LRR_8	319..380	CDD:290566	27/128 (21%)
		leucine-rich repeat	320..343	CDD:275380	5/24 (21%)
		leucine-rich repeat	344..369	CDD:275380	14/90 (16%)
		LRR_8	368..428	CDD:290566	19/59 (32%)
		leucine-rich repeat	370..393	CDD:275380	7/22 (32%)
		leucine-rich repeat	394..417	CDD:275380	6/22 (27%)
		leucine-rich repeat	418..441	CDD:275380	8/22 (36%)
phlp-2	NP_001337270.1	leucine-rich repeat	232..253	CDD:275380	6/29 (21%)
		leucine-rich repeat	254..288	CDD:275380	6/48 (13%)
		PLN00113	283..>718	CDD:331614	101/422 (24%)
		leucine-rich repeat	289..311	CDD:275380	5/21 (24%)
		leucine-rich repeat	312..334	CDD:275380	8/22 (36%)
		leucine-rich repeat	335..357	CDD:275380	10/22 (45%)
		leucine-rich repeat	358..379	CDD:275380	1/20 (5%)
		leucine-rich repeat	380..440	CDD:275380	14/59 (24%)
		leucine-rich repeat	441..485	CDD:275380	10/48 (21%)
		leucine-rich repeat	486..508	CDD:275380	6/21 (29%)
		leucine-rich repeat	509..534	CDD:275380	6/24 (25%)
		leucine-rich repeat	554..577	CDD:275380	1/22 (5%)
		leucine-rich repeat	578..602	CDD:275380	7/23 (30%)
		leucine-rich repeat	603..625	CDD:275380	5/21 (24%)
		leucine-rich repeat	626..649	CDD:275380	8/22 (36%)
		leucine-rich repeat	650..672	CDD:275380	6/21 (29%)
		leucine-rich repeat	673..694	CDD:275380	2/9 (22%)
		PP2Cc	754..985	CDD:214625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910