DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and sym-1

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_510426.1	Gene:	sym-1 / 181555	WormBaseID:	WBGene00006366	Length:	680	Species:	Caenorhabditis elegans

Alignment Length:	467	Identity:	116/467 - (24%)
Similarity:	202/467 - (43%)	Gaps:	84/467 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 DLTGAAPINVHTNGFSILPNLRQL-NLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDFFG 149
            |.|...|: :..:|..   .||.: .||....:::|      |.||:..|.    :|:..:.|..
Worm    32 DSTVEGPV-IKCSGHD---GLRMVEKLSTTTTMEVR------ELALENADI----IEVGPKAFKT 82

  Fly   150 -NLRKLIYANFSHNALKQCDLPHMPLLNRLELGHNRLVNATFGVCPQLQELILNDNQLIQLDVNA 213
             .::|||.:|                 ||:|..|:   :|..|:...:|||.|::|.|.::..:|
Worm    83 LRIKKLILSN-----------------NRIEKIHD---HAFTGLENVMQELSLSENNLKEVPTSA 127

  Fly   214 FRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFG----AVQNFVL---- 270
            ..||..|..|.|..|::.:|..:.|..:..|..:||..|.:.::..:.|.    ::||.:|
Worm   128 LAGLRVLNILSLKCNKIENITTKAFVNMTSLIDVNLGCNQICSMAADTFANVKMSLQNLILDNNC 192

  Fly   271 -------------HLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRK 322
                         :|..|.:..|:|..:..|.|..|..|.||.::.|:|:.:.........:|..
Worm   193 MTEFPSKAVRNMNNLIALHIKYNKINAIRQNDFVNLTSLSMLSLNGNNISEIKGGALQNTPNLHY 257

  Fly   323 LYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLA 387
            |||..|.:..:..........|..||||:||...:.:::|.|  |..::.|||:.||:..:.|.|
Worm   258 LYLNENNLQTLDNGVLEQFKQLQVLDLSFNNFTDITKEMFEG--LESIQHLNLDSNRISAVAPGA 320

  Fly   388 FSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRL 452
            |:..|.| .|.|.:|.|..:..:.......|:.:.|.:|.:.|::....:.|.::..:.:.||::
Worm   321 FAGTPLL-LLWLPNNCLTEVSQQTLKGAPFLRMVSLSNNNIREVHELSFDHLPNLHTLDLANNKI 384

  Fly   453 TFLAKVNVSFPNLKRVAIEGNPWQCPCFVKLQ-HWLATRDVVYLRD--NTGYYKGE--------- 505
            ..|...::|.|....|.::.||..|   ||.. |.|.:.:.::|.:  || ..|||
Worm   385 MSLQNKSLSGPENLAVRLQENPVVC---VKNGFHVLNSGEAIWLTNEANT-ICKGEWQAQTADLC 445

  Fly   506 --------RPLC 509
                    ||:|
Worm   446 PKAQPRPIRPVC 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	40/154 (26%)
		LRR_8	104..164	CDD:290566	15/61 (25%)
		leucine-rich repeat	106..129	CDD:275380	6/23 (26%)
		leucine-rich repeat	130..153	CDD:275380	4/23 (17%)
		leucine-rich repeat	154..195	CDD:275380	9/40 (23%)
		LRR_RI	194..455	CDD:238064	71/281 (25%)
		LRR_8	194..254	CDD:290566	19/59 (32%)
		leucine-rich repeat	196..219	CDD:275380	9/22 (41%)
		leucine-rich repeat	220..243	CDD:275380	6/22 (27%)
		leucine-rich repeat	244..267	CDD:275380	5/26 (19%)
		LRR_8	271..330	CDD:290566	17/58 (29%)
		leucine-rich repeat	272..295	CDD:275380	7/22 (32%)
		leucine-rich repeat	296..319	CDD:275380	5/22 (23%)
		LRR_8	319..380	CDD:290566	19/60 (32%)
		leucine-rich repeat	320..343	CDD:275380	5/22 (23%)
		leucine-rich repeat	344..369	CDD:275380	10/24 (42%)
		LRR_8	368..428	CDD:290566	17/59 (29%)
		leucine-rich repeat	370..393	CDD:275380	8/22 (36%)
		leucine-rich repeat	394..417	CDD:275380	5/22 (23%)
		leucine-rich repeat	418..441	CDD:275380	5/22 (23%)
sym-1	NP_510426.1	leucine-rich repeat	62..81	CDD:275380	6/28 (21%)
		LRR_5	74..208	CDD:290045	35/153 (23%)
		LRR_RI	81..384	CDD:238064	81/325 (25%)
		leucine-rich repeat	86..108	CDD:275380	10/41 (24%)
		leucine-rich repeat	110..133	CDD:275380	9/22 (41%)
		leucine-rich repeat	134..157	CDD:275380	6/22 (27%)
		leucine-rich repeat	158..182	CDD:275380	5/23 (22%)
		LRR_8	182..241	CDD:290566	14/58 (24%)
		leucine-rich repeat	183..206	CDD:275380	3/22 (14%)
		leucine-rich repeat	207..230	CDD:275380	7/22 (32%)
		leucine-rich repeat	231..254	CDD:275380	5/22 (23%)
		LRR_8	253..313	CDD:290566	19/61 (31%)
		leucine-rich repeat	255..278	CDD:275380	5/22 (23%)
		leucine-rich repeat	279..302	CDD:275380	10/24 (42%)
		LRR_8	302..384	CDD:290566	21/82 (26%)
		leucine-rich repeat	303..323	CDD:275380	8/19 (42%)
		leucine-rich repeat	350..373	CDD:275380	5/22 (23%)
		leucine-rich repeat	374..394	CDD:275380	3/19 (16%)
		leucine-rich repeat	399..410	CDD:275378	4/13 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910