Protein Alignment CG6749 and let-4

DIOPT Version :10

• Sequence 1: NP_648354.1
• Gene: CG6749 / 39144
• FlyBaseID: FBgn0036040
• Length: 552
• Species: Drosophila melanogaster
• Sequence 2: NP_510425.2
• Gene: let-4 / 181554
• WormBaseID: WBGene00002282
• Length: 773
• Species: Caenorhabditis elegans
• Alignment Length: 579
• Identity: 134/579 - (23%)
• Similarity: 238/579 - (41%)
• Gaps: 113/579 - (19%)

  Fly    11 LLLWLLCMGFPILHGADLCQPIGWRNFQCSEVASLQDLVDLGAENWHTLAIRNVQTELEVGSGEN 75
            |||.||.....:::..:.|..:..:...||||
 Worm     3 LLLCLLLFSTLLINSTNACPGVITQACFCSEV--------------------------------- 34

  Fly    76 ADHLANLLDLDLTGAAPI--NVHTNGFSILPNLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHN 138
              |...:||...:.|:.|  .:.||...: ..::.|.::...||::..|.|: ...::|:|.|.|
 Worm    35 --HSGIVLDCSNSSASGILQIIRTNQAQV-GLIQSLTMNQAELVELPPNFFS-GLFIRRLDLSQN 95

  Fly   139 QMELLDRDFFGNLRKLIYANFSHNALKQCDLPHMPLLNRLELGHN---RLVNATFGVCPQLQELI 200
            :::.:|...|..:.                    |:|..:.|.||   ::..|.....|.|..|.
 Worm    96 KIKKIDDAAFAGIN--------------------PVLEEVVLNHNLIEKVPAAALAGLPNLLRLD 140

  Fly   201 LNDNQLIQL-DVNAFRGLHGLLELQLSGNRLSSIGLETFQPLA-QLRKLNLSQNALDALRPNVFG 263
            |::|.:::: :...|..|:.|.::.|..|::.||...|||.:. .::.:||..|.:.|:..:...
 Worm   141 LSNNSIVEIQEQEIFPNLNKLYDINLGSNKIFSIHTSTFQNVKNSIQTINLGHNNMTAVPSSAIR 205

  Fly   264 AVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYN 328
            .::    .||.|.|..|||..|....|..|..|.:|:::.|.|..|:...|:.:.|||.|||..|
 Worm   206 GLK----QLQSLHLHKNRIEQLDALNFLNLPVLNLLNLAGNQIHELNRQAFLNVPSLRYLYLSGN 266

  Fly   329 AILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPF 393
            .|.::....|.....|:.|||:.|.:..:......|  |.::|:|.|..|::.::...||::...
 Worm   267 KITKLTAYQFQTFEQLEMLDLTNNEIGAIPANSLSG--LKQLRQLYLAHNKISNISSNAFTNSSI 329

  Fly   394 LEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRL------ 452
            : .|.|..||||:|...:.:.:..||::....|.::.||.:.....:|:..:.:..|:|
 Worm   330 V-VLVLSSNELKTLTAGIISGLPNLQQVSFRDNQIKTINRNAFYDAASLVMLDLAKNQLTEIAPT 393

  Fly   453 TFLAKVNVSFPNLKR-----------------VAIEGNPWQCPCFVKLQHWLATRDVVYLRDNTG 500
            ||||::|:...:|..                 |.::.||..|   .:..|.|.....||:||:..
 Worm   394 TFLAQLNLLLVDLSENKLPKTPYSAFNSRVGTVLLKENPLVC---TENLHMLQQGTGVYVRDSPD 455

  Fly   501 YYKGERP--------LCIVTNVDYCIQ--------NLQAVRRLGILGDFQGEQVEADAF 543
            ...|.:|        :.|||:.....|        .:|..|.:......|..|:.:.||
 Worm   456 IICGRKPTPKPEPVLVPIVTDSLISTQRPALVQIPKMQIHRNVHTTTGDQAPQIPSGAF 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_8	104..164	CDD:404697	11/59 (19%)
		leucine-rich repeat	106..129	CDD:275380	5/22 (23%)
		leucine-rich repeat	130..153	CDD:275380	6/22 (27%)
		leucine-rich repeat	154..195	CDD:275380	6/43 (14%)
		leucine-rich repeat	196..219	CDD:275380	6/23 (26%)
		LRR	199..>452	CDD:443914	69/254 (27%)
		leucine-rich repeat	220..243	CDD:275380	8/23 (35%)
		leucine-rich repeat	244..267	CDD:275380	4/22 (18%)
		leucine-rich repeat	272..295	CDD:275380	10/22 (45%)
		leucine-rich repeat	296..319	CDD:275380	6/22 (27%)
		leucine-rich repeat	320..343	CDD:275380	8/22 (36%)
		leucine-rich repeat	344..369	CDD:275380	7/24 (29%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..441	CDD:275380	5/22 (23%)
let-4	NP_510425.2	leucine-rich repeat	66..86	CDD:275380	5/20 (25%)
		LRR	85..414	CDD:443914	90/355 (25%)
		leucine-rich repeat	88..111	CDD:275380	6/42 (14%)
		leucine-rich repeat	112..135	CDD:275380	5/22 (23%)
		leucine-rich repeat	136..160	CDD:275380	6/23 (26%)
		leucine-rich repeat	161..184	CDD:275380	8/22 (36%)
		leucine-rich repeat	186..209	CDD:275380	4/26 (15%)
		leucine-rich repeat	210..257	CDD:275380	16/46 (35%)
		leucine-rich repeat	258..281	CDD:275380	8/22 (36%)
		leucine-rich repeat	282..305	CDD:275380	7/24 (29%)
		leucine-rich repeat	306..328	CDD:275380	6/21 (29%)
		leucine-rich repeat	329..350	CDD:275380	7/21 (33%)
		leucine-rich repeat	353..400	CDD:275380	12/46 (26%)
		leucine-rich repeat	356..376	CDD:275380	3/19 (16%)
		leucine-rich repeat	401..419	CDD:275380	1/17 (6%)