DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6749 and let-4

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_510425.2	Gene:	let-4 / 181554	WormBaseID:	WBGene00002282	Length:	773	Species:	Caenorhabditis elegans

Alignment Length:	579	Identity:	134/579 - (23%)
Similarity:	238/579 - (41%)	Gaps:	113/579 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLLWLLCMGFPILHGADLCQPIGWRNFQCSEVASLQDLVDLGAENWHTLAIRNVQTELEVGSGEN 75
            |||.||.....:::..:.|..:..:...||||
Worm     3 LLLCLLLFSTLLINSTNACPGVITQACFCSEV--------------------------------- 34

  Fly    76 ADHLANLLDLDLTGAAPI--NVHTNGFSILPNLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHN 138
              |...:||...:.|:.|  .:.||...: ..::.|.::...||::..|.|: ...::|:|.|.|
Worm    35 --HSGIVLDCSNSSASGILQIIRTNQAQV-GLIQSLTMNQAELVELPPNFFS-GLFIRRLDLSQN 95

  Fly   139 QMELLDRDFFGNLRKLIYANFSHNALKQCDLPHMPLLNRLELGHN---RLVNATFGVCPQLQELI 200
            :::.:|...|..:.                    |:|..:.|.||   ::..|.....|.|..|.
Worm    96 KIKKIDDAAFAGIN--------------------PVLEEVVLNHNLIEKVPAAALAGLPNLLRLD 140

  Fly   201 LNDNQLIQL-DVNAFRGLHGLLELQLSGNRLSSIGLETFQPLA-QLRKLNLSQNALDALRPNVFG 263
            |::|.:::: :...|..|:.|.::.|..|::.||...|||.:. .::.:||..|.:.|:..:...
Worm   141 LSNNSIVEIQEQEIFPNLNKLYDINLGSNKIFSIHTSTFQNVKNSIQTINLGHNNMTAVPSSAIR 205

  Fly   264 AVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYN 328
            .::    .||.|.|..|||..|....|..|..|.:|:::.|.|..|:...|:.:.|||.|||..|
Worm   206 GLK----QLQSLHLHKNRIEQLDALNFLNLPVLNLLNLAGNQIHELNRQAFLNVPSLRYLYLSGN 266

  Fly   329 AILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPF 393
            .|.::....|.....|:.|||:.|.:..:......|  |.::|:|.|..|::.::...||::...
Worm   267 KITKLTAYQFQTFEQLEMLDLTNNEIGAIPANSLSG--LKQLRQLYLAHNKISNISSNAFTNSSI 329

  Fly   394 LEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRL------ 452
            : .|.|..||||:|...:.:.:..||::....|.::.||.:.....:|:..:.:..|:|
Worm   330 V-VLVLSSNELKTLTAGIISGLPNLQQVSFRDNQIKTINRNAFYDAASLVMLDLAKNQLTEIAPT 393

  Fly   453 TFLAKVNVSFPNLKR-----------------VAIEGNPWQCPCFVKLQHWLATRDVVYLRDNTG 500
            ||||::|:...:|..                 |.::.||..|   .:..|.|.....||:||:..
Worm   394 TFLAQLNLLLVDLSENKLPKTPYSAFNSRVGTVLLKENPLVC---TENLHMLQQGTGVYVRDSPD 455

  Fly   501 YYKGERP--------LCIVTNVDYCIQ--------NLQAVRRLGILGDFQGEQVEADAF 543
            ...|.:|        :.|||:.....|        .:|..|.:......|..|:.:.||
Worm   456 IICGRKPTPKPEPVLVPIVTDSLISTQRPALVQIPKMQIHRNVHTTTGDQAPQIPSGAF 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	35/157 (22%)
		LRR_8	104..164	CDD:290566	11/59 (19%)
		leucine-rich repeat	106..129	CDD:275380	5/22 (23%)
		leucine-rich repeat	130..153	CDD:275380	6/22 (27%)
		leucine-rich repeat	154..195	CDD:275380	6/43 (14%)
		LRR_RI	194..455	CDD:238064	73/268 (27%)
		LRR_8	194..254	CDD:290566	18/61 (30%)
		leucine-rich repeat	196..219	CDD:275380	6/23 (26%)
		leucine-rich repeat	220..243	CDD:275380	8/23 (35%)
		leucine-rich repeat	244..267	CDD:275380	4/22 (18%)
		LRR_8	271..330	CDD:290566	23/58 (40%)
		leucine-rich repeat	272..295	CDD:275380	10/22 (45%)
		leucine-rich repeat	296..319	CDD:275380	6/22 (27%)
		LRR_8	319..380	CDD:290566	20/60 (33%)
		leucine-rich repeat	320..343	CDD:275380	8/22 (36%)
		leucine-rich repeat	344..369	CDD:275380	7/24 (29%)
		LRR_8	368..428	CDD:290566	16/59 (27%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..441	CDD:275380	5/22 (23%)
let-4	NP_510425.2	leucine-rich repeat	66..86	CDD:275380	5/20 (25%)
		LRR_RI	<71..275	CDD:238064	59/228 (26%)
		LRR_8	88..146	CDD:290566	17/77 (22%)
		leucine-rich repeat	88..111	CDD:275380	6/42 (14%)
		leucine-rich repeat	112..135	CDD:275380	5/22 (23%)
		leucine-rich repeat	136..160	CDD:275380	6/23 (26%)
		LRR_8	156..220	CDD:290566	18/67 (27%)
		leucine-rich repeat	161..184	CDD:275380	8/22 (36%)
		leucine-rich repeat	186..209	CDD:275380	4/26 (15%)
		leucine-rich repeat	210..257	CDD:275380	16/46 (35%)
		LRR_RI	<250..411	CDD:238064	44/163 (27%)
		LRR_8	256..316	CDD:290566	20/61 (33%)
		leucine-rich repeat	258..281	CDD:275380	8/22 (36%)
		leucine-rich repeat	282..305	CDD:275380	7/24 (29%)
		leucine-rich repeat	306..328	CDD:275380	6/21 (29%)
		LRR_8	327..387	CDD:290566	14/60 (23%)
		leucine-rich repeat	329..350	CDD:275380	7/21 (33%)
		leucine-rich repeat	353..400	CDD:275380	12/46 (26%)
		leucine-rich repeat	356..376	CDD:275380	3/19 (16%)
		leucine-rich repeat	401..419	CDD:275380	1/17 (6%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010