DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and lron-1

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_510424.4	Gene:	lron-1 / 181553	WormBaseID:	WBGene00008093	Length:	607	Species:	Caenorhabditis elegans

Alignment Length:	403	Identity:	91/403 - (22%)
Similarity:	148/403 - (36%)	Gaps:	135/403 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 QLQELILNDNQLIQLDVNAFRG--LHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDAL 257
            |:::|.|.:|.|.....|.|.|  .:.|.||::.||.:..|.......|.||:.|:|..|.::.:
Worm    83 QIKKLFLRNNGLRSFHPNTFTGNLENSLEELEIRGNYIDGIPQSGVSILKQLKILSLPDNLIEYV 147

  Fly   258 RPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRK 322
            :.|.|       |.....|                  .|..||:|.|::.::.|...:||.:|.:
Worm   148 QDNAF-------LSYHSRD------------------SLLKLDLSANNLTAIHPTGLLGLENLSQ 187

  Fly   323 LYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLA 387
            |.|..|.:.||.......:.:|:.|.|..|.:..:.....   .||.::.|:|..|:::.:...:
Worm   188 LSLDKNLLSEIPSQALENIPSLEDLSLGVNRIHTISRNSL---PLPNLKSLSLEVNQIRLIPSDS 249

  Fly   388 FSSLPFLEYLKLGHNELKSLDVRMF---------------------------------------- 412
            ||..|.|.||.||:|.|.|:|..||
Worm   250 FSETPLLSYLYLGNNLLTSIDASMFLHIGGLKVLSMSNNKDITSIQANGKLSVQQFKLCICILAF 314

  Fly   413 --AP----------------------MRRLQKLHLGHNLLEEINLDVLESLSSVQEI-------- 445
              ||                      ::.:|.:.|..|.:..|:.|...:|..:.|:
Worm   315 QHAPSLIRLELFDCSISRIEPKSLQKVQHIQVILLSRNQITRISHDTFSNLPELSELDLSGNSIN 379

  Fly   446 LVD----------------NNRLTFLAKVNVSFPNL---------KRVAIEGNPWQCPCFVKLQH 485
            .||                :|||..|.. ||.:.:|         ::::|:.|||:|.   |...
Worm   380 AVDDFAFSQLPMLTSLDLSSNRLESLPS-NVIYDSLMQKKTSPVQRKLSIQNNPWRCD---KDLM 440

  Fly   486 WLATRDVVYLRDN 498
            ||..    :||||
Worm   441 WLRK----WLRDN 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	20/62 (32%)
		LRR_8	104..164	CDD:290566
		leucine-rich repeat	106..129	CDD:275380
		leucine-rich repeat	130..153	CDD:275380
		leucine-rich repeat	154..195	CDD:275380	91/403 (23%)
		LRR_RI	194..455	CDD:238064	75/349 (21%)
		LRR_8	194..254	CDD:290566	20/60 (33%)
		leucine-rich repeat	196..219	CDD:275380	7/24 (29%)
		leucine-rich repeat	220..243	CDD:275380	7/22 (32%)
		leucine-rich repeat	244..267	CDD:275380	6/22 (27%)
		LRR_8	271..330	CDD:290566	13/58 (22%)
		leucine-rich repeat	272..295	CDD:275380	1/22 (5%)
		leucine-rich repeat	296..319	CDD:275380	8/22 (36%)
		LRR_8	319..380	CDD:290566	15/60 (25%)
		leucine-rich repeat	320..343	CDD:275380	6/22 (27%)
		leucine-rich repeat	344..369	CDD:275380	5/24 (21%)
		LRR_8	368..428	CDD:290566	23/123 (19%)
		leucine-rich repeat	370..393	CDD:275380	5/22 (23%)
		leucine-rich repeat	394..417	CDD:275380	13/86 (15%)
		leucine-rich repeat	418..441	CDD:275380	6/22 (27%)
lron-1	NP_510424.4	PRK15370	<58..>289	CDD:185268	61/233 (26%)
		leucine-rich repeat	85..109	CDD:275380	7/23 (30%)
		leucine-rich repeat	110..133	CDD:275380	7/22 (32%)
		leucine-rich repeat	134..157	CDD:275380	7/29 (24%)
		leucine-rich repeat	161..184	CDD:275380	8/22 (36%)
		leucine-rich repeat	185..208	CDD:275380	6/22 (27%)
		leucine-rich repeat	209..231	CDD:275380	5/24 (21%)
		leucine-rich repeat	232..255	CDD:275380	5/22 (23%)
		leucine-rich repeat	256..279	CDD:275380	11/22 (50%)
		leucine-rich repeat	280..319	CDD:275380	1/38 (3%)
		leucine-rich repeat	320..343	CDD:275380	0/22 (0%)
		LRR_8	343..402	CDD:338972	10/58 (17%)
		leucine-rich repeat	344..367	CDD:275380	6/22 (27%)
		leucine-rich repeat	368..391	CDD:275380	3/22 (14%)
		leucine-rich repeat	392..410	CDD:275380	5/18 (28%)
		leucine-rich repeat	414..435	CDD:275378	5/20 (25%)
		LRRCT	431..>472	CDD:214507	11/26 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910