DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and lron-7

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001360787.1	Gene:	lron-7 / 180991	WormBaseID:	WBGene00019351	Length:	633	Species:	Caenorhabditis elegans

Alignment Length:	481	Identity:	119/481 - (24%)
Similarity:	185/481 - (38%)	Gaps:	160/481 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 LSGCGLVDIRGNHFAPESA---LQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNALKQCDLPHM 172
            |..|.:.:|..:....||.   |:.:|     :.::.:||     :.|.|.|:.|.:
Worm   191 LCHCDVHEIDCSEITMESGDPYLRTLD-----VAIMKKDF-----EPITAKFTKNKI-------- 237

  Fly   173 PLLNRLELGHNRLVNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLET 237
                      :||.|..  |.|:.::.:                    ..|.:|.|.:..|..:.
Worm   238 ----------SRLQNDK--VLPKFEKFV--------------------SILDVSYNEIRFIDNDV 270

  Fly   238 FQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVS 302
            |:|...|.||.||.|.|..::.:||.|.:| .||  :|||..|||:::.||.|..|::|::|.:.
Worm   271 FKPFTNLTKLYLSHNVLQTVKKDVFDAAKN-TLH--RLDLGYNRIKVVSDNSFDTLSKLKVLSLD 332

  Fly   303 RNSIASLSPAHFVGLGSLR------------------------KLYLQYNAILEIKPATFAALLN 343
            .|.|.:.....|.||.||.                        ||.|:.|.:.|| ||..|.|.:
Worm   333 GNPIKAWRKEMFKGLDSLEELSLDNCNIENLPADIFEYLPKLVKLSLRENPLEEI-PAVVAHLKS 396

  Fly   344 LDTLDLSYNNLEFLEEQIFGGNT-----------------------LPRMRRLNLNGNR-MKHLH 384
            |..:|||..||..:.:..|.|::                       ||:::.|.||.|: ::.||
Worm   397 LKDIDLSVTNLTEIRDHAFAGDSDLEEIILEKMPFLTVVRDCGFCGLPQLKTLILNDNKYLQELH 461

  Fly   385 PLAFSSLPFLEYLKL--GHNE--LKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEI 445
            |.||.      |:|.  ||..  :.||.:               ||          .::|::.|.
Worm   462 PNAFG------YIKSQPGHKSAAITSLQI---------------HN----------SNISTISEH 495

  Fly   446 LVDNNRLTFLAKVNVSFPNLKRVAIEGNPWQCPC---FVKLQHWLATRDVVYLRDNTGYYKGERP 507
            :||             :.|||...:.||||.|.|   |:..:.:...:|.|..:..:......|.
Worm   496 MVD-------------YDNLKTFQVGGNPWNCNCDTQFMLEEKFAFKQDSVAPKCTSPAGLNGRL 547

  Fly   508 LCIVTNVDYCIQNLQAVRRLGILGDF 533
            |..|...|.|    :..|.||..|.|
Worm   548 LVTVRASDAC----EDARFLGRSGRF 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	31/147 (21%)
		LRR_8	104..164	CDD:290566	13/55 (24%)
		leucine-rich repeat	106..129	CDD:275380	4/17 (24%)
		leucine-rich repeat	130..153	CDD:275380	4/22 (18%)
		leucine-rich repeat	154..195	CDD:275380	8/40 (20%)
		LRR_RI	194..455	CDD:238064	80/312 (26%)
		LRR_8	194..254	CDD:290566	13/59 (22%)
		leucine-rich repeat	196..219	CDD:275380	0/22 (0%)
		leucine-rich repeat	220..243	CDD:275380	6/22 (27%)
		leucine-rich repeat	244..267	CDD:275380	10/22 (45%)
		LRR_8	271..330	CDD:290566	24/82 (29%)
		leucine-rich repeat	272..295	CDD:275380	10/22 (45%)
		leucine-rich repeat	296..319	CDD:275380	7/22 (32%)
		LRR_8	319..380	CDD:290566	26/108 (24%)
		leucine-rich repeat	320..343	CDD:275380	11/46 (24%)
		leucine-rich repeat	344..369	CDD:275380	9/47 (19%)
		LRR_8	368..428	CDD:290566	18/64 (28%)
		leucine-rich repeat	370..393	CDD:275380	9/23 (39%)
		leucine-rich repeat	394..417	CDD:275380	6/26 (23%)
		leucine-rich repeat	418..441	CDD:275380	2/22 (9%)
lron-7	NP_001360787.1	LRR	<251..464	CDD:227223	65/236 (28%)
		leucine-rich repeat	253..276	CDD:275380	6/42 (14%)
		leucine-rich repeat	277..300	CDD:275380	10/22 (45%)
		leucine-rich repeat	302..325	CDD:275380	12/24 (50%)
		leucine-rich repeat	326..349	CDD:275380	7/22 (32%)
		leucine-rich repeat	350..373	CDD:275380	1/22 (5%)
		leucine-rich repeat	374..396	CDD:275380	10/22 (45%)
		leucine-rich repeat	397..420	CDD:275380	8/22 (36%)
		leucine-rich repeat	421..445	CDD:275380	1/23 (4%)
		leucine-rich repeat	446..470	CDD:275380	10/29 (34%)
		LRRCT	510..557	CDD:214507	12/46 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910