DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and lron-2

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_505402.1	Gene:	lron-2 / 179309	WormBaseID:	WBGene00022789	Length:	575	Species:	Caenorhabditis elegans

Alignment Length:	582	Identity:	135/582 - (23%)
Similarity:	212/582 - (36%)	Gaps:	185/582 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PILHGADLCQPIGWRNFQ--CSEVASLQDLVDLGAENWHTLAIRNVQTELEVGSGE--------- 74
            |.|.||..|.|..:....  |....|||:            ||:.:|...::....
Worm    20 PALSGACRCAPSVYEPVAIICQNAGSLQN------------AIQAIQAARDIPIDSLTILDTAIP 72

  Fly    75 ----NADHLANLLDLDLTGAAPINVHTNGFS--ILPNLRQLNLSGCGLVDIRGNHFAPESALQRI 133
                ||.....:|.|.|......|:....|:  :|.:|.:|:|:...|..|      |::.:.|:
Worm    73 TIPANAFQSFTILRLVLNRNTLQNIDDQAFNGPLLDSLIELDLNDNNLGQI------PQTGIPRL 131

  Fly   134 DFSHNQMELLDRDFFGNLRKLIYAN---------FSHNALKQCDLPHMPLLNRLELGHNRLVNAT 189
                           .||||| |.|         .:.||.:..|     ||.:|||..|||.:||
Worm   132 ---------------RNLRKL-YLNRNRINQLSSTAFNAFESRD-----LLLKLELAGNRLTDAT 175

  Fly   190 FGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSI-----------------GLET 237
            .|                  |...||.|..|.||.|..|.|:||                 ||.:
Worm   176 LG------------------DATVFRPLTLLQELSLETNSLTSIPSSALVNQRNTLTNLNLGLNS 222

  Fly   238 FQ--PLAQ-----LRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLAR 295
            ..  |:..     |..|:|..|.:..:.|..|..|.|    ||.|.::||:........||.:.:
Worm   223 INEVPVGALDFPVLSSLSLEFNGITVIPPQAFQGVPN----LQFLYMTGNKFPSWAPEMFRYITQ 283

  Fly   296 LQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQ 360
            |:.|.:....|:.:....|:.:.:|.:|.:...|:..|:...|.....:..:.|:.|.|..:...
Worm   284 LKTLGIGETPISVIPNNAFMHIPNLIRLEMSEAAVDTIERGAFQRTPQIQAIVLNKNRLSQVRAD 348

  Fly   361 IFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGH 425
            .|.|  |..:..::|.|||:.::.||.|::||.:.:|.:.:|.|:::...:|
Worm   349 FFEG--LNDLYSIDLQGNRIDNVQPLGFANLPAISHLDISYNLLQTMPSNVF------------- 398

  Fly   426 NLLEEINLDVLESLSSVQEILVDNNRLTFLAKVNVSFPNLKRVAIE-GNPWQCPCFVKLQHWLAT 489
                                     :.:||.:     ||.:||... ||||.|...::   |..|
Worm   399 -------------------------QNSFLPQ-----PNDRRVIYACGNPWYCNSELE---WFRT 430

  Fly   490 RDVVYLRDNTGYYKGERPLCI----------------VTNVDYCIQNLQAV----RRLGILG 531
                .||||.. ...|:|.|.                :.:||:|..|.:|.    |.|.::|
Worm   431 ----LLRDNLD-IDVEKPGCTAVCTSSPNGCPVEGTPLRSVDFCQNNEEAQPLVGRALSMVG 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	48/185 (26%)
		LRR_8	104..164	CDD:290566	15/68 (22%)
		leucine-rich repeat	106..129	CDD:275380	6/22 (27%)
		leucine-rich repeat	130..153	CDD:275380	3/22 (14%)
		leucine-rich repeat	154..195	CDD:275380	17/49 (35%)
		LRR_RI	194..455	CDD:238064	58/284 (20%)
		LRR_8	194..254	CDD:290566	19/83 (23%)
		leucine-rich repeat	196..219	CDD:275380	4/22 (18%)
		leucine-rich repeat	220..243	CDD:275380	11/41 (27%)
		leucine-rich repeat	244..267	CDD:275380	7/22 (32%)
		LRR_8	271..330	CDD:290566	13/58 (22%)
		leucine-rich repeat	272..295	CDD:275380	7/22 (32%)
		leucine-rich repeat	296..319	CDD:275380	4/22 (18%)
		LRR_8	319..380	CDD:290566	14/60 (23%)
		leucine-rich repeat	320..343	CDD:275380	5/22 (23%)
		leucine-rich repeat	344..369	CDD:275380	6/24 (25%)
		LRR_8	368..428	CDD:290566	13/59 (22%)
		leucine-rich repeat	370..393	CDD:275380	8/22 (36%)
		leucine-rich repeat	394..417	CDD:275380	4/22 (18%)
		leucine-rich repeat	418..441	CDD:275380	0/22 (0%)
lron-2	NP_505402.1	leucine-rich repeat	64..84	CDD:275380	2/19 (11%)
		leucine-rich repeat	85..109	CDD:275380	6/23 (26%)
		LRR_8	86..144	CDD:290566	19/79 (24%)
		LRR_RI	109..294	CDD:238064	60/233 (26%)
		leucine-rich repeat	110..133	CDD:275380	7/43 (16%)
		LRR_8	132..198	CDD:290566	30/89 (34%)
		leucine-rich repeat	134..157	CDD:275380	8/23 (35%)
		leucine-rich repeat	161..187	CDD:275380	14/43 (33%)
		leucine-rich repeat	188..211	CDD:275380	8/22 (36%)
		LRR_8	212..270	CDD:290566	16/61 (26%)
		leucine-rich repeat	213..235	CDD:275380	3/21 (14%)
		leucine-rich repeat	236..259	CDD:275380	7/22 (32%)
		leucine-rich repeat	260..283	CDD:275380	7/22 (32%)
		LRR_8	282..342	CDD:290566	11/59 (19%)
		leucine-rich repeat	284..307	CDD:275380	4/22 (18%)
		leucine-rich repeat	308..355	CDD:275380	11/48 (23%)
		LRR_8	330..390	CDD:290566	17/61 (28%)
		leucine-rich repeat	356..377	CDD:275380	7/20 (35%)
		leucine-rich repeat	380..400	CDD:275380	4/57 (7%)
		Ca_hom_mod	<481..>504	CDD:291464	3/7 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910