DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and sma-10

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_499896.1	Gene:	sma-10 / 176849	WormBaseID:	WBGene00020649	Length:	881	Species:	Caenorhabditis elegans

Alignment Length:	424	Identity:	109/424 - (25%)
Similarity:	179/424 - (42%)	Gaps:	73/424 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 EVGSGENADHLANLL------DLD-LTGAAPINVHTNGFSILP--------NLRQLNLSGCGLVD 118
            |:|..|..|..:||:      :|. |.....:::..|..|.||        |:.:|:|:...:.|
Worm   121 ELGHLEKLDLRSNLISTVTSEELSYLAAVRSVDLSRNLISYLPKPTTSAKVNIEKLDLASNSITD 185

  Fly   119 IRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNALKQCDLPHMPLLNRLELGHN 183
            |..:||:..:.|..:..:.|.:..|::..|..||||...:.:.|.:::...          |..|
Worm   186 IGTDHFSSFNTLVTLKLARNHITTLNQFSFSRLRKLESLDLTRNMIREVRF----------LAFN 240

  Fly   184 RLVNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLN 248
            :|        |.||.:.|..|.:.:||...|....||..|.||.||:.::.......|..|..|:
Worm   241 QL--------PSLQNVSLARNDVYRLDDGMFYACEGLKHLNLSTNRVQAVTEGWMFGLTSLEVLD 297

  Fly   249 LSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAH 313
            ||.|.:.:...:.:.....    |:.|.|..|||:.|....||||.:|:.|.:|.|||.||....
Worm   298 LSYNQIQSFHISSWSHTPK----LKWLSLHSNRIQSLPSGSFRVLRQLEELILSANSIDSLHKFA 358

  Fly   314 FVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQ--IFGGNTLPRMRRLNLN 376
            .||:.||.|                        ||||.|.|....|.  :....::|.:|.|...
Worm   359 LVGMSSLHK------------------------LDLSSNTLAVCVEDGAVLYNTSMPFLRSLRFT 399

  Fly   377 GNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSS 441
            .|:::.:...||...|.||.|.|..|.:.::....|.|:...:.:....::|.:..:..|.|.
Worm   400 NNQLRVIPKRAFERFPALEELDLTDNPIATIHPEAFEPLELKRLVMNSSSILCDCQISWLASW-- 462

  Fly   442 VQEILVDNNRLTFLAKVNVSFP----NLKRVAIE 471
            :..:.:|.:  :.:||  .|:|    :|..|||:
Worm   463 IYRLKLDKS--SIIAK--CSYPPPLADLYVVAID 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	42/160 (26%)
		LRR_8	104..164	CDD:290566	17/67 (25%)
		leucine-rich repeat	106..129	CDD:275380	6/22 (27%)
		leucine-rich repeat	130..153	CDD:275380	5/22 (23%)
		leucine-rich repeat	154..195	CDD:275380	5/40 (13%)
		LRR_RI	194..455	CDD:238064	70/262 (27%)
		LRR_8	194..254	CDD:290566	21/59 (36%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		leucine-rich repeat	220..243	CDD:275380	7/22 (32%)
		leucine-rich repeat	244..267	CDD:275380	5/22 (23%)
		LRR_8	271..330	CDD:290566	24/58 (41%)
		leucine-rich repeat	272..295	CDD:275380	11/22 (50%)
		leucine-rich repeat	296..319	CDD:275380	10/22 (45%)
		LRR_8	319..380	CDD:290566	14/62 (23%)
		leucine-rich repeat	320..343	CDD:275380	2/22 (9%)
		leucine-rich repeat	344..369	CDD:275380	7/26 (27%)
		LRR_8	368..428	CDD:290566	14/59 (24%)
		leucine-rich repeat	370..393	CDD:275380	5/22 (23%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..441	CDD:275380	3/22 (14%)
sma-10	NP_499896.1	LRRNT	29..54	CDD:214470
		leucine-rich repeat	55..77	CDD:275380
		LRR_8	78..135	CDD:290566	5/13 (38%)
		LRR_4	78..116	CDD:289563
		leucine-rich repeat	78..101	CDD:275380
		LRR_RI	100..303	CDD:238064	52/199 (26%)
		leucine-rich repeat	102..124	CDD:275380	1/2 (50%)
		leucine-rich repeat	125..148	CDD:275380	6/22 (27%)
		leucine-rich repeat	149..172	CDD:275380	4/22 (18%)
		LRR_8	172..231	CDD:290566	16/58 (28%)
		leucine-rich repeat	173..196	CDD:275380	6/22 (27%)
		leucine-rich repeat	197..220	CDD:275380	5/22 (23%)
		leucine-rich repeat	221..244	CDD:275380	5/40 (13%)
		LRR_8	243..303	CDD:290566	21/59 (36%)
		leucine-rich repeat	245..268	CDD:275380	7/22 (32%)
		LRR_RI	269..453	CDD:238064	58/211 (27%)
		leucine-rich repeat	269..292	CDD:275380	7/22 (32%)
		leucine-rich repeat	293..316	CDD:275380	5/22 (23%)
		LRR_8	315..373	CDD:290566	28/85 (33%)
		leucine-rich repeat	317..340	CDD:275380	11/22 (50%)
		leucine-rich repeat	341..364	CDD:275380	10/22 (45%)
		leucine-rich repeat	365..392	CDD:275380	9/50 (18%)
		LRR_8	393..450	CDD:290566	13/56 (23%)
		leucine-rich repeat	393..416	CDD:275380	5/22 (23%)
		leucine-rich repeat	417..438	CDD:275380	6/20 (30%)
		I-set	506..612	CDD:254352
		Ig	522..606	CDD:143165
		I-set	616..705	CDD:254352
		Ig	633..705	CDD:299845
		Ig	716..786	CDD:299845
		IG	719..788	CDD:214652
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910