Protein Alignment CG6749 and pan-1

DIOPT Version :10

• Sequence 1: NP_648354.1
• Gene: CG6749 / 39144
• FlyBaseID: FBgn0036040
• Length: 552
• Species: Drosophila melanogaster
• Sequence 2: NP_497925.1
• Gene: pan-1 / 175596
• WormBaseID: WBGene00003915
• Length: 594
• Species: Caenorhabditis elegans
• Alignment Length: 458
• Identity: 109/458 - (23%)
• Similarity: 186/458 - (40%)
• Gaps: 100/458 - (21%)

  Fly    68 LEVGSGENADHLANLLDLDLTGAAPINVHTNGFSILPN-------LRQLNLSGCGLVDIRGNHF- 124
            :|..|...|....||..|:.|....:.:..:..::||.       .:|:.|..|||..::.|.|
 Worm    59 IECESASIASVSENLASLNGTELGRLTIRDSTVNVLPQDLFENVFAKQVKLERCGLSTLQPNSFQ 123

  Fly   125 APESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNALKQCDLPHMPLLNRLE---LGHNR-- 184
            :...:.:.:....|:::.|::..|..|:.|...:.:.|.:::.|:.....|.::|   |..|.
 Worm   124 SLGGSAELLSLRENRIKKLEKGLFTGLKSLKTLDLAMNKIQEIDVGAFEELKKVEELLLNENDIR 188

  Fly   185 -LVNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLN 248
             |...||.....|::|.|.:..|..:...|||||:.|.:|.||.|.|.:|....|..|..||.|:
 Worm   189 VLKTGTFDGMKNLKKLTLQNCNLEIIQKGAFRGLNSLEQLILSNNNLENIDWTIFSALKNLRVLD 253

  Fly   249 LSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRL---------LFD-NQFRVLA--------- 294
            |..|.:..:....|..::..||:...:| |...|:|         ||| |:...:.
 Worm   254 LGSNKISNVEMKSFPKLEKLVLNNNTID-SMKSIKLKDLPSLVVALFDRNKIESIGDMDMFGLTR 317

  Fly   295 --RLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILE--------IKPATFAALLNLDTLDL 349
              |::.|.::||:::.:||..|....:|..|.||||.|.|        ::....|:|..|.||.|
 Worm   318 SDRIETLSLARNNLSQISPKAFQHTPNLITLLLQYNQIEELSSHSPSQVRTPFLASLKKLVTLQL 382

  Fly   350 SYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAP 414
            |.|||..:..                             ..||
 Worm   383 SSNNLSVIRS-----------------------------DELP---------------------- 396

  Fly   415 MRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLAK---VNVSFPNLKRVAIEGNPWQ 476
             :.|..|.|.||::.:|....||.: .::.:.:.:|:|.:|.:   .:.|..:::.|.:..|||.
 Worm   397 -KSLSSLALDHNVISKIEARALEGM-EIKRLYLHSNKLNYLYQGTFDSFSPKSVEAVDVSLNPWV 459

  Fly   477 CPC 479
            |.|
 Worm   460 CVC 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_8	104..164	CDD:404697	14/67 (21%)
		leucine-rich repeat	106..129	CDD:275380	7/23 (30%)
		leucine-rich repeat	130..153	CDD:275380	4/22 (18%)
		leucine-rich repeat	154..195	CDD:275380	10/46 (22%)
		leucine-rich repeat	196..219	CDD:275380	9/22 (41%)
		LRR	199..>452	CDD:443914	69/281 (25%)
		leucine-rich repeat	220..243	CDD:275380	9/22 (41%)
		leucine-rich repeat	244..267	CDD:275380	6/22 (27%)
		leucine-rich repeat	272..295	CDD:275380	8/43 (19%)
		leucine-rich repeat	296..319	CDD:275380	6/22 (27%)
		leucine-rich repeat	320..343	CDD:275380	10/30 (33%)
		leucine-rich repeat	344..369	CDD:275380	8/24 (33%)
		leucine-rich repeat	370..393	CDD:275380	1/22 (5%)
		leucine-rich repeat	394..417	CDD:275380	0/22 (0%)
		leucine-rich repeat	418..441	CDD:275380	8/22 (36%)
pan-1	NP_497925.1	leucine-rich repeat	81..104	CDD:275380	2/22 (9%)
		leucine-rich repeat	105..128	CDD:275380	7/22 (32%)
		leucine-rich repeat	130..152	CDD:275380	4/21 (19%)
		LRR_8	132..187	CDD:404697	11/54 (20%)
		leucine-rich repeat	153..176	CDD:275380	4/22 (18%)
		LRR	163..>418	CDD:443914	75/307 (24%)
		leucine-rich repeat	177..200	CDD:275380	6/22 (27%)
		leucine-rich repeat	201..224	CDD:275380	9/22 (41%)
		leucine-rich repeat	225..248	CDD:275380	9/22 (41%)
		leucine-rich repeat	249..269	CDD:275380	6/19 (32%)
		leucine-rich repeat	270..293	CDD:275380	6/23 (26%)
		leucine-rich repeat	294..320	CDD:275380	4/25 (16%)
		leucine-rich repeat	321..344	CDD:275380	6/22 (27%)
		leucine-rich repeat	377..398	CDD:275380	10/72 (14%)
		leucine-rich repeat	399..420	CDD:275380	8/20 (40%)
		leucine-rich repeat	423..442	CDD:275380	3/18 (17%)