DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and pan-1

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_497925.1	Gene:	pan-1 / 175596	WormBaseID:	WBGene00003915	Length:	594	Species:	Caenorhabditis elegans

Alignment Length:	458	Identity:	109/458 - (23%)
Similarity:	186/458 - (40%)	Gaps:	100/458 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 LEVGSGENADHLANLLDLDLTGAAPINVHTNGFSILPN-------LRQLNLSGCGLVDIRGNHF- 124
            :|..|...|....||..|:.|....:.:..:..::||.       .:|:.|..|||..::.|.|
Worm    59 IECESASIASVSENLASLNGTELGRLTIRDSTVNVLPQDLFENVFAKQVKLERCGLSTLQPNSFQ 123

  Fly   125 APESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNALKQCDLPHMPLLNRLE---LGHNR-- 184
            :...:.:.:....|:::.|::..|..|:.|...:.:.|.:::.|:.....|.::|   |..|.
Worm   124 SLGGSAELLSLRENRIKKLEKGLFTGLKSLKTLDLAMNKIQEIDVGAFEELKKVEELLLNENDIR 188

  Fly   185 -LVNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLN 248
             |...||.....|::|.|.:..|..:...|||||:.|.:|.||.|.|.:|....|..|..||.|:
Worm   189 VLKTGTFDGMKNLKKLTLQNCNLEIIQKGAFRGLNSLEQLILSNNNLENIDWTIFSALKNLRVLD 253

  Fly   249 LSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRL---------LFD-NQFRVLA--------- 294
            |..|.:..:....|..::..||:...:| |...|:|         ||| |:...:.
Worm   254 LGSNKISNVEMKSFPKLEKLVLNNNTID-SMKSIKLKDLPSLVVALFDRNKIESIGDMDMFGLTR 317

  Fly   295 --RLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILE--------IKPATFAALLNLDTLDL 349
              |::.|.::||:::.:||..|....:|..|.||||.|.|        ::....|:|..|.||.|
Worm   318 SDRIETLSLARNNLSQISPKAFQHTPNLITLLLQYNQIEELSSHSPSQVRTPFLASLKKLVTLQL 382

  Fly   350 SYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAP 414
            |.|||..:..                             ..||
Worm   383 SSNNLSVIRS-----------------------------DELP---------------------- 396

  Fly   415 MRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLAK---VNVSFPNLKRVAIEGNPWQ 476
             :.|..|.|.||::.:|....||.: .::.:.:.:|:|.:|.:   .:.|..:::.|.:..|||.
Worm   397 -KSLSSLALDHNVISKIEARALEGM-EIKRLYLHSNKLNYLYQGTFDSFSPKSVEAVDVSLNPWV 459

  Fly   477 CPC 479
            |.|
Worm   460 CVC 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	46/166 (28%)
		LRR_8	104..164	CDD:290566	14/67 (21%)
		leucine-rich repeat	106..129	CDD:275380	7/23 (30%)
		leucine-rich repeat	130..153	CDD:275380	4/22 (18%)
		leucine-rich repeat	154..195	CDD:275380	10/46 (22%)
		LRR_RI	194..455	CDD:238064	71/289 (25%)
		LRR_8	194..254	CDD:290566	23/59 (39%)
		leucine-rich repeat	196..219	CDD:275380	9/22 (41%)
		leucine-rich repeat	220..243	CDD:275380	9/22 (41%)
		leucine-rich repeat	244..267	CDD:275380	6/22 (27%)
		LRR_8	271..330	CDD:290566	21/79 (27%)
		leucine-rich repeat	272..295	CDD:275380	8/43 (19%)
		leucine-rich repeat	296..319	CDD:275380	6/22 (27%)
		LRR_8	319..380	CDD:290566	18/68 (26%)
		leucine-rich repeat	320..343	CDD:275380	10/30 (33%)
		leucine-rich repeat	344..369	CDD:275380	8/24 (33%)
		LRR_8	368..428	CDD:290566	7/59 (12%)
		leucine-rich repeat	370..393	CDD:275380	1/22 (5%)
		leucine-rich repeat	394..417	CDD:275380	0/22 (0%)
		leucine-rich repeat	418..441	CDD:275380	8/22 (36%)
pan-1	NP_497925.1	leucine-rich repeat	130..152	CDD:275380	4/21 (19%)
		LRR_8	132..187	CDD:290566	11/54 (20%)
		leucine-rich repeat	153..176	CDD:275380	4/22 (18%)
		leucine-rich repeat	177..200	CDD:275380	6/22 (27%)
		LRR_8	199..259	CDD:290566	23/59 (39%)
		leucine-rich repeat	201..224	CDD:275380	9/22 (41%)
		LRR_RI	224..434	CDD:238064	62/263 (24%)
		leucine-rich repeat	225..248	CDD:275380	9/22 (41%)
		leucine-rich repeat	249..269	CDD:275380	6/19 (32%)
		LRR_8	268..355	CDD:290566	23/87 (26%)
		leucine-rich repeat	270..293	CDD:275380	6/23 (26%)
		leucine-rich repeat	294..320	CDD:275380	4/25 (16%)
		LRR_8	320..387	CDD:290566	23/66 (35%)
		leucine-rich repeat	321..344	CDD:275380	6/22 (27%)
		LRR_8	375..432	CDD:290566	19/109 (17%)
		leucine-rich repeat	377..398	CDD:275380	10/72 (14%)
		leucine-rich repeat	399..420	CDD:275380	8/20 (40%)
		leucine-rich repeat	423..442	CDD:275380	3/18 (17%)
		LRR_RI	80..326	CDD:238064	59/246 (24%)
		leucine-rich repeat	81..104	CDD:275380	2/22 (9%)
		leucine-rich repeat	105..128	CDD:275380	7/22 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910