DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and egg-6

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_492348.1	Gene:	egg-6 / 172670	WormBaseID:	WBGene00010621	Length:	961	Species:	Caenorhabditis elegans

Alignment Length:	437	Identity:	106/437 - (24%)
Similarity:	181/437 - (41%)	Gaps:	75/437 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 PIGWRNFQCSEVASLQDLVDLGAENWHTLAIRNVQTELEVGSGENADHLANLLDLDLTGAAPINV 95
            |..||:.:    |:::.:...|.|         ::|....|      :|:.|:.::|......::
Worm    96 PTAWRHVE----ATIEHITINGNE---------LKTVPVFG------NLSTLMSMNLNSNQISSI 141

  Fly    96 HTNGFSILPNLRQLNLSGCGLVDIRGNHFAPES------ALQRIDFSHNQMELLDRDFFGNLRKL 154
            ....|:.|..|.||.|....:.|     |.|:|      :|..:|.|.|.::.:......|...|
Worm   142 PDKAFNGLSALTQLRLENNAICD-----FPPKSLDAVKASLVLLDVSGNCLDAIPAQILRNAANL 201

  Fly   155 IYANFSHNALKQC---DLPHMPLLNRLELGHN---RLVNATFGVCPQLQELILNDNQLIQLDVNA 213
            :|.:...|.:.:.   :|.::|.|..|.:.:|   |:....|...||||.|.|.||.:..||.|.
Worm   202 MYLDLGSNNISEINNFELMNLPFLRELRVQNNTLRRIHPMAFMNVPQLQYLYLQDNIISTLDGNR 266

  Fly   214 FRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLS 278
            .:|...|..|.:|.|.|  ..|.:.:.|..|:::.:..|.:..:....|....|    ||.:.:.
Worm   267 LQGFKNLEVLDVSNNAL--YALPSLKDLPNLKQVRVDGNLITKIETLAFSNNPN----LQLISVQ 325

  Fly   279 GNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLN 343
            .|.|..:..|.|..|.:|.:|.|..||:|.:....|.|:.:|::|.::.|.:..:..::||.|.:
Worm   326 NNNIVQISRNSFESLDKLVVLLVGNNSLAKIERGMFDGMKNLQQLSIRNNTLTALDASSFAQLAH 390

  Fly   344 LDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLD 408
            |.||||.:|.:..:||.                          .|..|..|.:|.|.:|::....
Worm   391 LTTLDLGHNKIHDIEEG--------------------------TFDKLSKLFWLDLSNNKISGFK 429

  Fly   409 VRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFL 455
            ..:|       |..:.:.||:...|...||.:.....|:.|...|||
Worm   430 TSVF-------KKKISNILLDGNQLICDESFNEFLTYLIANKVRTFL 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	45/164 (27%)
		LRR_8	104..164	CDD:290566	16/65 (25%)
		leucine-rich repeat	106..129	CDD:275380	8/28 (29%)
		leucine-rich repeat	130..153	CDD:275380	5/22 (23%)
		leucine-rich repeat	154..195	CDD:275380	10/46 (22%)
		LRR_RI	194..455	CDD:238064	68/260 (26%)
		LRR_8	194..254	CDD:290566	21/59 (36%)
		leucine-rich repeat	196..219	CDD:275380	10/22 (45%)
		leucine-rich repeat	220..243	CDD:275380	7/22 (32%)
		leucine-rich repeat	244..267	CDD:275380	3/22 (14%)
		LRR_8	271..330	CDD:290566	18/58 (31%)
		leucine-rich repeat	272..295	CDD:275380	7/22 (32%)
		leucine-rich repeat	296..319	CDD:275380	8/22 (36%)
		LRR_8	319..380	CDD:290566	14/60 (23%)
		leucine-rich repeat	320..343	CDD:275380	6/22 (27%)
		leucine-rich repeat	344..369	CDD:275380	8/24 (33%)
		LRR_8	368..428	CDD:290566	8/59 (14%)
		leucine-rich repeat	370..393	CDD:275380	2/22 (9%)
		leucine-rich repeat	394..417	CDD:275380	5/22 (23%)
		leucine-rich repeat	418..441	CDD:275380	6/22 (27%)
egg-6	NP_492348.1	LRR_8	107..162	CDD:290566	13/69 (19%)
		leucine-rich repeat	107..127	CDD:275380	5/34 (15%)
		leucine-rich repeat	128..151	CDD:275380	4/22 (18%)
		LRR_RI	<144..281	CDD:238064	40/141 (28%)
		leucine-rich repeat	152..200	CDD:275380	13/52 (25%)
		LRR_8	176..233	CDD:290566	12/56 (21%)
		leucine-rich repeat	201..224	CDD:275380	4/22 (18%)
		LRR_8	225..283	CDD:290566	21/57 (37%)
		leucine-rich repeat	225..248	CDD:275380	5/22 (23%)
		LRR_RI	<240..458	CDD:238064	66/256 (26%)
		leucine-rich repeat	249..272	CDD:275380	10/22 (45%)
		LRR_8	271..329	CDD:290566	14/63 (22%)
		leucine-rich repeat	273..294	CDD:275380	7/22 (32%)
		leucine-rich repeat	295..318	CDD:275380	3/22 (14%)
		LRR_8	317..375	CDD:290566	18/61 (30%)
		leucine-rich repeat	319..342	CDD:275380	7/22 (32%)
		leucine-rich repeat	343..366	CDD:275380	8/22 (36%)
		LRR_8	365..425	CDD:290566	20/85 (24%)
		leucine-rich repeat	367..390	CDD:275380	6/22 (27%)
		leucine-rich repeat	391..414	CDD:275380	10/48 (21%)
		leucine-rich repeat	415..434	CDD:275380	5/25 (20%)
		leucine-rich repeat	437..449	CDD:275378	3/11 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910