DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and Igfals

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001351825.1	Gene:	Igfals / 16005	MGIID:	107973	Length:	638	Species:	Mus musculus

Alignment Length:	496	Identity:	152/496 - (30%)
Similarity:	225/496 - (45%)	Gaps:	75/496 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 NFQCSEVASLQDLVDLGAEN-WHTLAIRNVQTELEVGSGENADHLANL-LDLDLTGAAPINVHTN 98
            |.|.|.:.||:....||.:| :|....||:...|..|...:...||:| |..:|.|    .:...
Mouse   139 NLQGSWLRSLEPQALLGLQNLYHLHLERNLLRSLAAGLFRHTPSLASLSLGNNLLG----RLEEG 199

  Fly    99 GFSILPNLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNA 163
            .|..|.:|..|||....||.:      |::..|.:               |||.:|:.|......
Mouse   200 LFRGLSHLWDLNLGWNSLVVL------PDTVFQGL---------------GNLHELVLAGNKLTY 243

  Fly   164 LKQCDLPHMPLLNRLELGHNRLVNATFGV---CPQLQELILNDNQLIQLDVNAFRGLHGLLELQL 225
            |:...|..:..|..|:|..|.|.:....|   .|:||:|.|:.|.:..:...||.|:..|..|.|
Mouse   244 LQPALLCGLGELRELDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDL 308

  Fly   226 SGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLH-LQQLDLSGNRIRLLFDNQ 289
            |.||::.:..:||..|..|..|.|:.||:.:|||..|..     || |::|.|..||||.|.:..
Mouse   309 SHNRVAGLLEDTFPGLLGLHVLRLAHNAITSLRPRTFKD-----LHFLEELQLGHNRIRQLGEKT 368

  Fly   290 FRVLARLQMLDVSRNSIASLS-----------------------PAH-FVGLGSLRKLYLQYNAI 330
            |..|.:|::|.::.|.|..:.                       |.| |.|||.|..|:|:::.:
Mouse   369 FEGLGQLEVLTLNDNQIHEVKVGAFFGLFNVAVMNLSGNCLRSLPEHVFQGLGRLHSLHLEHSCL 433

  Fly   331 LEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLE 395
            ..|:..|||.|..|..|.|..|::..:|||...|  |..:..|:|..|::.||....|..|..||
Mouse   434 GRIRLHTFAGLSGLRRLFLRDNSISSIEEQSLAG--LSELLELDLTANQLTHLPRQLFQGLGQLE 496

  Fly   396 YLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRL-TFLAKVN 459
            ||.|.:|:|..|...:..|::|...|.|.||.||.....:..||..::.:.:.||.| ||:.:
Mouse   497 YLLLSNNQLTMLSEDVLGPLQRAFWLDLSHNRLETPAEGLFSSLGRLRYLNLRNNSLQTFVPQ-- 559

  Fly   460 VSFPNLKRVAIEGNPWQCPCFVKLQHWLATRDVVYLRDNTG 500
               |.|:|:.::.|||.|.|.:|     |.||  :...|.|
Mouse   560 ---PGLERLWLDANPWDCSCPLK-----ALRD--FALQNPG 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	45/155 (29%)
		LRR_8	104..164	CDD:290566	13/59 (22%)
		leucine-rich repeat	106..129	CDD:275380	7/22 (32%)
		leucine-rich repeat	130..153	CDD:275380	4/22 (18%)
		leucine-rich repeat	154..195	CDD:275380	10/43 (23%)
		LRR_RI	194..455	CDD:238064	95/286 (33%)
		LRR_8	194..254	CDD:290566	22/59 (37%)
		leucine-rich repeat	196..219	CDD:275380	8/22 (36%)
		leucine-rich repeat	220..243	CDD:275380	9/22 (41%)
		leucine-rich repeat	244..267	CDD:275380	9/22 (41%)
		LRR_8	271..330	CDD:290566	24/83 (29%)
		leucine-rich repeat	272..295	CDD:275380	10/22 (45%)
		leucine-rich repeat	296..319	CDD:275380	9/46 (20%)
		LRR_8	319..380	CDD:290566	20/60 (33%)
		leucine-rich repeat	320..343	CDD:275380	8/22 (36%)
		leucine-rich repeat	344..369	CDD:275380	9/24 (38%)
		LRR_8	368..428	CDD:290566	21/59 (36%)
		leucine-rich repeat	370..393	CDD:275380	7/22 (32%)
		leucine-rich repeat	394..417	CDD:275380	9/22 (41%)
		leucine-rich repeat	418..441	CDD:275380	8/22 (36%)
Igfals	NP_001351825.1	LRRNT	75..113	CDD:214470
		leucine-rich repeat	92..110	CDD:275380
		PLN00113	96..>558	CDD:331614	138/450 (31%)
		leucine-rich repeat	114..134	CDD:275380
		leucine-rich repeat	135..158	CDD:275380	7/18 (39%)
		leucine-rich repeat	159..182	CDD:275380	5/22 (23%)
		leucine-rich repeat	183..206	CDD:275380	8/26 (31%)
		leucine-rich repeat	207..230	CDD:275380	8/43 (19%)
		leucine-rich repeat	231..254	CDD:275380	5/22 (23%)
		leucine-rich repeat	255..278	CDD:275380	6/22 (27%)
		leucine-rich repeat	279..302	CDD:275380	8/22 (36%)
		leucine-rich repeat	303..326	CDD:275380	9/22 (41%)
		leucine-rich repeat	327..350	CDD:275380	10/27 (37%)
		leucine-rich repeat	351..374	CDD:275380	10/22 (45%)
		leucine-rich repeat	375..396	CDD:275380	4/20 (20%)
		leucine-rich repeat	423..446	CDD:275380	8/22 (36%)
		leucine-rich repeat	447..470	CDD:275380	9/24 (38%)
		leucine-rich repeat	471..494	CDD:275380	7/22 (32%)
		leucine-rich repeat	495..516	CDD:275380	8/20 (40%)
		leucine-rich repeat	519..542	CDD:275380	8/22 (36%)
		leucine-rich repeat	543..561	CDD:275380	5/22 (23%)
		TPKR_C2	570..613	CDD:326558	11/28 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910