DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and Gp5

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_032174.2	Gene:	Gp5 / 14729	MGIID:	1096363	Length:	567	Species:	Mus musculus

Alignment Length:	466	Identity:	127/466 - (27%)
Similarity:	201/466 - (43%)	Gaps:	75/466 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 SGENADHLANLLDLDLTGAAPINVHTNGFSILPNLRQLNLSGCGLVDIRGNHFAPESALQRIDFS 136
            ||.:..|:|.|                  .:..||..:.|.......:|.:.|:..:.|||:..|
Mouse    36 SGGSVAHIAEL------------------GLPTNLTHILLFRMDQGILRNHSFSGMTVLQRLMLS 82

  Fly   137 HNQMELLDRDFFGNLRKLIYANFSHNALKQCDLPHMPLLNRLELGHNRLVNATFGVCPQLQELIL 201
            .:.:..:|...|.:|.||.....:.|.:.:  ||. .:|:::.|               |::|.|
Mouse    83 DSHISAIDPGTFNDLVKLKTLRLTRNKISR--LPR-AILDKMVL---------------LEQLFL 129

  Fly   202 NDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQ 266
            :.|.|..||.|.|:.|..|.||.|:.|:||.:....|..|.:|:.|:||:|.|..|...:.||
Mouse   130 DHNALRDLDQNLFQQLRNLQELGLNQNQLSFLPANLFSSLRELKLLDLSRNNLTHLPKGLLGA-- 192

  Fly   267 NFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAIL 331
              .:.|::|.|..|::..:.......|..|..|.:.||.:.|::|..|..||:|..|.|..|.:.
Mouse   193 --QVKLEKLLLYSNQLTSVDSGLLSNLGALTELRLERNHLRSVAPGAFDRLGNLSSLTLSGNLLE 255

  Fly   332 EIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEY 396
            .:.||.|..:.::..|.|..|.||.|.:.:||  .:..:|.|.|||..:..|...||.:|..|:.
Mouse   256 SLPPALFLHVSSVSRLTLFENPLEELPDVLFG--EMAGLRELWLNGTHLSTLPAAAFRNLSGLQT 318

  Fly   397 LKLGHN-ELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLAK--- 457
            |.|..| .|.:|...:|..:|.|:.|.|..|.|.|:..|.|..|..::::.:.:|||..|.:
Mouse   319 LGLTRNPRLSALPRGVFQGLRELRVLALHTNALAELRDDALRGLGHLRQVSLRHNRLRALPRTLF 383

  Fly   458 ----------------------VNVSFPNLKRVAIEGNPWQCPC----FVKLQHWLATRDVVYLR 496
                                  |..:.|.|.:|.:..|||.|.|    |::   ||.....:..|
Mouse   384 RNLSSLESVQLEHNQLETLPGDVFAALPQLTQVLLGHNPWLCDCGLWPFLQ---WLRHHPDILGR 445

  Fly   497 DNTGYYKGERP 507
            |.....:|..|
Mouse   446 DEPPQCRGPEP 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	44/152 (29%)
		LRR_8	104..164	CDD:290566	15/59 (25%)
		leucine-rich repeat	106..129	CDD:275380	4/22 (18%)
		leucine-rich repeat	130..153	CDD:275380	7/22 (32%)
		leucine-rich repeat	154..195	CDD:275380	6/40 (15%)
		LRR_RI	194..455	CDD:238064	86/261 (33%)
		LRR_8	194..254	CDD:290566	24/59 (41%)
		leucine-rich repeat	196..219	CDD:275380	10/22 (45%)
		leucine-rich repeat	220..243	CDD:275380	9/22 (41%)
		leucine-rich repeat	244..267	CDD:275380	9/22 (41%)
		LRR_8	271..330	CDD:290566	18/58 (31%)
		leucine-rich repeat	272..295	CDD:275380	5/22 (23%)
		leucine-rich repeat	296..319	CDD:275380	8/22 (36%)
		LRR_8	319..380	CDD:290566	20/60 (33%)
		leucine-rich repeat	320..343	CDD:275380	7/22 (32%)
		leucine-rich repeat	344..369	CDD:275380	8/24 (33%)
		LRR_8	368..428	CDD:290566	21/60 (35%)
		leucine-rich repeat	370..393	CDD:275380	9/22 (41%)
		leucine-rich repeat	394..417	CDD:275380	7/23 (30%)
		leucine-rich repeat	418..441	CDD:275380	9/22 (41%)
Gp5	NP_032174.2	LRR 1	75..96		6/20 (30%)
		LRR_8	76..134	CDD:290566	18/75 (24%)
		leucine-rich repeat	76..99	CDD:275380	7/22 (32%)
		LRR 2	99..120		6/23 (26%)
		leucine-rich repeat	100..123	CDD:275380	5/25 (20%)
		LRR 3	123..144		10/35 (29%)
		LRR_8	124..182	CDD:290566	24/57 (42%)
		leucine-rich repeat	124..147	CDD:275380	10/22 (45%)
		LRR_RI	126..402	CDD:238064	86/281 (31%)
		LRR 4	147..168		8/20 (40%)
		leucine-rich repeat	148..171	CDD:275380	9/22 (41%)
		LRR 5	171..193		9/25 (36%)
		leucine-rich repeat	172..195	CDD:275380	9/26 (35%)
		LRR_8	195..254	CDD:290566	18/58 (31%)
		LRR 6	195..216		4/20 (20%)
		leucine-rich repeat	196..219	CDD:275380	5/22 (23%)
		LRR 7	219..240		7/20 (35%)
		leucine-rich repeat	220..243	CDD:275380	8/22 (36%)
		LRR_8	243..302	CDD:290566	20/60 (33%)
		LRR 8	243..264		7/20 (35%)
		leucine-rich repeat	244..267	CDD:275380	7/22 (32%)
		LRR 9	267..288		8/22 (36%)
		leucine-rich repeat	268..291	CDD:275380	8/24 (33%)
		LRR 10	291..312		8/20 (40%)
		leucine-rich repeat	292..315	CDD:275380	9/22 (41%)
		LRR_8	314..375	CDD:290566	18/60 (30%)
		LRR 11	315..337		7/21 (33%)
		leucine-rich repeat	316..338	CDD:275380	7/21 (33%)
		LRR 12	340..361		8/20 (40%)
		leucine-rich repeat	341..364	CDD:275380	9/22 (41%)
		LRR_8	364..422	CDD:290566	8/57 (14%)
		LRR 13	364..385		4/20 (20%)
		leucine-rich repeat	365..388	CDD:275380	4/22 (18%)
		LRR 14	388..409		1/20 (5%)
		leucine-rich repeat	389..410	CDD:275380	1/20 (5%)
		TPKR_C2	421..>454	CDD:301599	10/35 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910