DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and LRRC15

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001128529.2	Gene:	LRRC15 / 131578	HGNCID:	20818	Length:	587	Species:	Homo sapiens

Alignment Length:	463	Identity:	133/463 - (28%)
Similarity:	205/463 - (44%)	Gaps:	61/463 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 LDLTGAAPINVHTNGFSILP-NLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDFF 148
            ::.|||..:.|.|.    || |...|.:....:.::..:.|...|||..:....|::..:....|
Human    43 VECTGARIVAVPTP----LPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAF 103

  Fly   149 GNLRKLIYANFSHNALKQCDLPHMPLLNRLELGHNRLVNATFGVCPQLQELILNDNQLIQLDVNA 213
            .||..|.|.:.::|.|:.     :|:             ..|.....|:.|:|:.|||:|:....
Human   104 RNLGSLRYLSLANNKLQV-----LPI-------------GLFQGLDSLESLLLSSNQLLQIQPAH 150

  Fly   214 FRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLS 278
            |.....|.||||.||.|..|....|..|..|.||||.:|:|..:.|.||..:.|    ||.|.|.
Human   151 FSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGN----LQVLRLY 211

  Fly   279 GNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLN 343
            .||:..:....|..|..||.|.:.:|.|..|||..|....:|::|||..|.|.::.|:.|..|..
Human   212 ENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQ 276

  Fly   344 LDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLD 408
            |:.|.|..|:|:.|...|||  .:|.:|.|.|..|.:..|....||:|..|:.|.|..|::..:.
Human   277 LNRLTLFGNSLKELSPGIFG--PMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFIS 339

  Fly   409 VRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRL-----TFLAKVN----VSFPN 464
            ...|..:..|::|.|..|.|::::.:|...|:::|.|.:.||||     ...|.||    :...|
Human   340 PGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQN 404

  Fly   465 ----------------LKRVAIEGNPWQCPC-FVKLQHWLATR------DVVYLRDNTGYYKGER 506
                            |..:.:..|||:|.. .:.|::||...      |.|.:..:....:|:.
Human   405 NQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQS 469

  Fly   507 PLCIVTNV 514
            .:.|..||
Human   470 LIIINVNV 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	44/153 (29%)
		LRR_8	104..164	CDD:290566	14/60 (23%)
		leucine-rich repeat	106..129	CDD:275380	2/22 (9%)
		leucine-rich repeat	130..153	CDD:275380	5/22 (23%)
		leucine-rich repeat	154..195	CDD:275380	6/40 (15%)
		LRR_RI	194..455	CDD:238064	92/265 (35%)
		LRR_8	194..254	CDD:290566	25/59 (42%)
		leucine-rich repeat	196..219	CDD:275380	8/22 (36%)
		leucine-rich repeat	220..243	CDD:275380	11/22 (50%)
		leucine-rich repeat	244..267	CDD:275380	10/22 (45%)
		LRR_8	271..330	CDD:290566	22/58 (38%)
		leucine-rich repeat	272..295	CDD:275380	8/22 (36%)
		leucine-rich repeat	296..319	CDD:275380	9/22 (41%)
		LRR_8	319..380	CDD:290566	23/60 (38%)
		leucine-rich repeat	320..343	CDD:275380	9/22 (41%)
		leucine-rich repeat	344..369	CDD:275380	9/24 (38%)
		LRR_8	368..428	CDD:290566	18/59 (31%)
		leucine-rich repeat	370..393	CDD:275380	8/22 (36%)
		leucine-rich repeat	394..417	CDD:275380	5/22 (23%)
		leucine-rich repeat	418..441	CDD:275380	7/22 (32%)
LRRC15	NP_001128529.2	LRR_8	60..119	CDD:290566	13/58 (22%)
		LRR_RI	63..309	CDD:238064	84/269 (31%)
		LRR_8	88..167	CDD:290566	25/96 (26%)
		leucine-rich repeat	88..108	CDD:275380	4/19 (21%)
		leucine-rich repeat	109..156	CDD:275380	14/64 (22%)
		leucine-rich repeat	157..180	CDD:275380	11/22 (50%)
		LRR_8	180..239	CDD:290566	23/62 (37%)
		leucine-rich repeat	181..204	CDD:275380	10/22 (45%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		LRR_8	228..287	CDD:290566	22/58 (38%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		leucine-rich repeat	253..276	CDD:275380	9/22 (41%)
		leucine-rich repeat	277..300	CDD:275380	9/24 (38%)
		LRR_8	299..359	CDD:290566	18/59 (31%)
		LRR_4	299..340	CDD:289563	13/40 (33%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		LRR_4	324..364	CDD:289563	10/39 (26%)
		leucine-rich repeat	325..348	CDD:275380	5/22 (23%)
		leucine-rich repeat	349..370	CDD:275380	6/20 (30%)
		LRR_8	372..430	CDD:290566	11/57 (19%)
		leucine-rich repeat	373..393	CDD:275380	6/19 (32%)
		leucine-rich repeat	397..418	CDD:275380	1/20 (5%)
		TPKR_C2	429..>468	CDD:301599	9/38 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910