DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and AgaP_AGAP011947

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_320584.4	Gene:	AgaP_AGAP011947 / 1280722	VectorBaseID:	AGAP011947	Length:	1233	Species:	Anopheles gambiae

Alignment Length:	530	Identity:	141/530 - (26%)
Similarity:	220/530 - (41%)	Gaps:	119/530 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 DLTGAAPINVHTNGFSIL--------PNLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQMEL 142
            :|.|...|::..|.|..:        |:||:|::||..|..|....|.....|:.::.|.|::.|
Mosquito   432 NLPGLKGIDISYNSFRRMDPNLLVGVPSLRRLDISGNTLSVIDAGAFTHTPMLETVNISFNELSL 496

  Fly   143 LDRDFFGNLRKLIYANFSHNALKQ-------------------CDLP---------HMPLLNRLE 179
            :....|.:|..:...:..:|.|::                   ..||         .:|.|..|:
Mosquito   497 IHSATFRDLNHMFELDAGNNKLQEFIPGLPVAVERVNLHGNMITQLPPPTTASQLWDLPNLRMLD 561

  Fly   180 LGHN---RLVNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPL 241
            :..|   ||..|.|...|||:.|.|..|||..:|..:..||..|..|.|..||:.::....|.||
Mosquito   562 ISANQLTRLPRAVFKPTPQLRVLSLARNQLQSVDDGSLSGLSRLEILNLQDNRVLALHERCFSPL 626

  Fly   242 AQLRKLNLSQNALDALRPNV---------FGAVQNFVLH-----------LQQLDLSGNRIRLLF 286
            ..||:|||..|.::.|..|:         |.|.:|.::.           ||.||||.|::|.|
Mosquito   627 ENLRELNLQGNRIEVLVDNLLDSNALLEQFDASRNSIVEISPKAFRNSRSLQTLDLSSNQLREL- 690

  Fly   287 DNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSY 351
            ......||.|:.||||.|.:..|||...|...:|.:|.:..|.:.::...:...|..|..||||.
Mosquito   691 PESLSGLAELRELDVSFNQLTELSPNVLVSWRNLEELKVSNNKVNQLHQGSLRNLPLLQYLDLSS 755

  Fly   352 NNLEFLE------------------------EQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLP 392
            |.|..||                        |::|  ..||.::.::|..|.::::.|.:|...|
Mosquito   756 NELTLLEHGSLRNLPELQELVLADNKLSELKERVF--EDLPNLQAVHLQQNNLRYISPYSFFRSP 818

  Fly   393 FLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNN------- 450
            .:.||.|..|:.:|||......:|.|:.|.|..|.:.:|....|..|..:.|:.:|||
Mosquito   819 SIVYLNLSANQFRSLDSVGLRSVRNLEVLDLTGNSIRKITPSPLRGLDWLVELKLDNNKICGIQG 883

  Fly   451 -------RLTFLAKVN-----VSFP-------NLKRVAIEGNPWQCPCFVKLQHWLATRDVVYLR 496
                   ||..|:..|     |..|       |:..:.::|||..|.|.:.   |.    :.:|:
Mosquito   884 EPFATMPRLRVLSMRNNQMSRVPEPIFRSLRTNIAILDVDGNPLDCSCDML---WY----MAWLQ 941

  Fly   497 DNTGYYKGER 506
            ::...|.|.|
Mosquito   942 ESRSLYPGPR 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	52/191 (27%)
		LRR_8	104..164	CDD:290566	16/59 (27%)
		leucine-rich repeat	106..129	CDD:275380	8/22 (36%)
		leucine-rich repeat	130..153	CDD:275380	6/22 (27%)
		leucine-rich repeat	154..195	CDD:275380	12/71 (17%)
		LRR_RI	194..455	CDD:238064	94/318 (30%)
		LRR_8	194..254	CDD:290566	25/59 (42%)
		leucine-rich repeat	196..219	CDD:275380	9/22 (41%)
		leucine-rich repeat	220..243	CDD:275380	8/22 (36%)
		leucine-rich repeat	244..267	CDD:275380	10/31 (32%)
		LRR_8	271..330	CDD:290566	24/69 (35%)
		leucine-rich repeat	272..295	CDD:275380	10/22 (45%)
		leucine-rich repeat	296..319	CDD:275380	10/22 (45%)
		LRR_8	319..380	CDD:290566	19/84 (23%)
		leucine-rich repeat	320..343	CDD:275380	4/22 (18%)
		leucine-rich repeat	344..369	CDD:275380	12/48 (25%)
		LRR_8	368..428	CDD:290566	18/59 (31%)
		leucine-rich repeat	370..393	CDD:275380	4/22 (18%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..441	CDD:275380	7/22 (32%)
AgaP_AGAP011947	XP_320584.4	leucine-rich repeat	73..94	CDD:275380
		leucine-rich repeat	95..118	CDD:275380
		LRR_RI	<97..290	CDD:238064
		leucine-rich repeat	119..142	CDD:275380
		LRR_8	141..196	CDD:290566
		leucine-rich repeat	143..164	CDD:275380
		leucine-rich repeat	165..188	CDD:275380
		LRR_8	188..248	CDD:290566
		LRR_RI	199..495	CDD:238064	17/62 (27%)
		leucine-rich repeat	214..237	CDD:275380
		leucine-rich repeat	238..263	CDD:275380
		LRR_8	263..322	CDD:290566
		leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..311	CDD:275380
		leucine-rich repeat	312..337	CDD:275380
		leucine-rich repeat	338..363	CDD:275380
		LRR_8	364..422	CDD:290566
		leucine-rich repeat	364..387	CDD:275380
		leucine-rich repeat	388..411	CDD:275380
		LRR_8	410..468	CDD:290566	10/35 (29%)
		leucine-rich repeat	412..435	CDD:275380	1/2 (50%)
		leucine-rich repeat	436..459	CDD:275380	3/22 (14%)
		LRR_8	458..518	CDD:290566	16/59 (27%)
		leucine-rich repeat	460..483	CDD:275380	8/22 (36%)
		LRR_8	484..567	CDD:290566	14/82 (17%)
		leucine-rich repeat	484..507	CDD:275380	6/22 (27%)
		leucine-rich repeat	508..556	CDD:275380	4/47 (9%)
		LRR_RI	529..793	CDD:238064	76/266 (29%)
		leucine-rich repeat	557..580	CDD:275380	7/22 (32%)
		LRR_8	579..639	CDD:290566	25/59 (42%)
		leucine-rich repeat	581..604	CDD:275380	9/22 (41%)
		leucine-rich repeat	605..628	CDD:275380	8/22 (36%)
		leucine-rich repeat	629..652	CDD:275380	8/22 (36%)
		leucine-rich repeat	653..676	CDD:275380	3/22 (14%)
		LRR_8	675..734	CDD:290566	24/59 (41%)
		leucine-rich repeat	677..699	CDD:275380	10/22 (45%)
		leucine-rich repeat	700..723	CDD:275380	10/22 (45%)
		LRR_8	722..782	CDD:290566	13/59 (22%)
		leucine-rich repeat	724..747	CDD:275380	4/22 (18%)
		leucine-rich repeat	748..771	CDD:275380	9/22 (41%)
		LRR_8	770..830	CDD:290566	13/61 (21%)
		leucine-rich repeat	772..795	CDD:275380	3/24 (13%)
		leucine-rich repeat	796..819	CDD:275380	4/22 (18%)
		leucine-rich repeat	820..843	CDD:275380	7/22 (32%)
		LRR_8	842..902	CDD:290566	16/59 (27%)
		leucine-rich repeat	844..867	CDD:275380	7/22 (32%)
		leucine-rich repeat	868..891	CDD:275380	4/22 (18%)
		leucine-rich repeat	892..913	CDD:275380	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910