DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and AgaP_AGAP011371

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_317948.4	Gene:	AgaP_AGAP011371 / 1278325	VectorBaseID:	AGAP011371	Length:	320	Species:	Anopheles gambiae

Alignment Length:	317	Identity:	87/317 - (27%)
Similarity:	150/317 - (47%)	Gaps:	39/317 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 RLELGHNRL--VNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQ 239
            ||.:..||:  ::::.....:|..|.|:.|.|:.:....|.....||:|.|:.|:|.::...||.
Mosquito     1 RLVIKFNRIKSIDSSIQFYTELTMLDLSYNHLLSIPERIFMYQKKLLQLHLNNNKLGAVTNRTFG 65

  Fly   240 PLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLA--RLQMLDVS 302
            .|.:||.|||..|.:|.:...:|.|:..    |::|:|..|||..|..:.|..||  ||:.||:.
Mosquito    66 GLDELRVLNLRGNFIDEIGSELFKALPK----LEELNLGQNRIATLHASAFDGLANLRLRRLDIH 126

  Fly   303 RNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTL 367
            .:.:.:::...|.||.::|.|.|..|.:|::.....:.|..|:.|.:..|:.|.:.|..|.|  |
Mosquito   127 GSMLVNITSDTFRGLENIRSLDLSDNHLLKVPTVQLSGLKRLEELTIGQNDFETIPEGAFFG--L 189

  Fly   368 PRMRRLNLNGN-RMKHLHPLAFSSLPFLEYLKLGHN-ELKSLDVRMFAPMRRLQKLHLGHNLLEE 430
            ..::.::::|. .::.:...|||:.|.||.:.:..| ||..||...||.:..::|:.|.
Mosquito   190 SNLKSIDISGALNLRQVQSGAFSANPNLESITIASNKELLELDEGAFAGLPHIRKVSLR------ 248

  Fly   431 INLDVLESLSSVQEILVDNNRLTFLAKVNVSFPNLKRVAIEGNPWQCPCFVKLQHWL 487
                             ||...||..:: :.:.:|....:..||..|.|.|.   ||
Mosquito   249 -----------------DNKIATFHEEL-LPWKHLAEFDLTENPLVCDCNVL---WL 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	25/80 (31%)
		LRR_8	104..164	CDD:290566
		leucine-rich repeat	106..129	CDD:275380
		leucine-rich repeat	130..153	CDD:275380
		leucine-rich repeat	154..195	CDD:275380	4/19 (21%)
		LRR_RI	194..455	CDD:238064	74/264 (28%)
		LRR_8	194..254	CDD:290566	21/59 (36%)
		leucine-rich repeat	196..219	CDD:275380	6/22 (27%)
		leucine-rich repeat	220..243	CDD:275380	9/22 (41%)
		leucine-rich repeat	244..267	CDD:275380	9/22 (41%)
		LRR_8	271..330	CDD:290566	21/60 (35%)
		leucine-rich repeat	272..295	CDD:275380	10/24 (42%)
		leucine-rich repeat	296..319	CDD:275380	6/22 (27%)
		LRR_8	319..380	CDD:290566	15/61 (25%)
		leucine-rich repeat	320..343	CDD:275380	6/22 (27%)
		leucine-rich repeat	344..369	CDD:275380	8/24 (33%)
		LRR_8	368..428	CDD:290566	16/61 (26%)
		leucine-rich repeat	370..393	CDD:275380	4/23 (17%)
		leucine-rich repeat	394..417	CDD:275380	9/23 (39%)
		leucine-rich repeat	418..441	CDD:275380	2/22 (9%)
AgaP_AGAP011371	XP_317948.4	leucine-rich repeat	1..21	CDD:275380	4/19 (21%)
		LRR_8	20..78	CDD:290566	20/57 (35%)
		LRR_RI	<22..156	CDD:238064	45/137 (33%)
		leucine-rich repeat	22..45	CDD:275380	6/22 (27%)
		leucine-rich repeat	46..69	CDD:275380	9/22 (41%)
		LRR_8	69..130	CDD:290566	23/64 (36%)
		leucine-rich repeat	70..93	CDD:275380	9/22 (41%)
		leucine-rich repeat	94..117	CDD:275380	9/22 (41%)
		leucine-rich repeat	120..143	CDD:275380	6/22 (27%)
		LRR_8	143..199	CDD:290566	14/57 (25%)
		leucine-rich repeat	144..167	CDD:275380	6/22 (27%)
		LRR_5	168..>250	CDD:290045	24/106 (23%)
		leucine-rich repeat	168..191	CDD:275380	8/24 (33%)
		leucine-rich repeat	192..216	CDD:275380	4/23 (17%)
		leucine-rich repeat	217..241	CDD:275380	9/23 (39%)
		leucine-rich repeat	242..260	CDD:275380	6/41 (15%)
		LRRCT	273..320	CDD:214507	7/15 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910