DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and AgaP_AGAP007829

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_317669.4	Gene:	AgaP_AGAP007829 / 1278128	VectorBaseID:	AGAP007829	Length:	586	Species:	Anopheles gambiae

Alignment Length:	521	Identity:	130/521 - (24%)
Similarity:	215/521 - (41%)	Gaps:	124/521 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 ENAD-----HLANLLDLDLTGAAPINVHTNGFS-ILPNLRQLNLSGCGLVDIRGNHFAPESALQR 132
            :|.|     :|..|..:||......:|..:.|| ...:|.:|.|:...|..|..:.|||...|:.
Mosquito    14 QNIDVSLFCNLTQLQTIDLKYNKIYSVTASQFSGCTSSLLELLLANNRLKRIIPSVFAPFRRLEV 78

  Fly   133 IDFSHNQMELLDRDFFGNLR--KLIYANFSHNALKQ---CDLPHMPLLNRLELGHNRLVNATFGV 192
            ||.|||.:|    .|.|..:  ::.....|:|.|.|   |:...||.:..|.:..|:|:    ||
Mosquito    79 IDLSHNMLE----SFVGRFQNTEISQLLISNNLLPQIDPCEWVLMPNMTSLFIEKNKLI----GV 135

  Fly   193 --C----PQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLE--TFQPLAQLRKLNL 249
              |    |.|..:.|.:|.|..:.:.||..|..|..|:||.|.:.|:...  |.:.|.:|..|.|
Mosquito   136 PDCLHKFPNLYSINLENNLLSSVSLAAFAQLKVLQYLRLSWNPIVSLATVPLTLKNLPKLSVLKL 200

  Fly   250 SQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASL----S 310
            ||:.::                           ::.|:: |..|:.|..|::..|.||||    |
Mosquito   201 SQSPIE---------------------------QIAFES-FCNLSALTSLNLKNNLIASLTFQAS 237

  Fly   311 PAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNL 375
            .|......||.::.|..|.:..:....|||:..|:.:||.||.:|.    :.|..:.|::..:.|
Mosquito   238 SATSQCYASLARVSLSSNKLKHVNMTVFAAMRALEIIDLEYNQIEV----VAGRLSNPKITTVIL 298

  Fly   376 NGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLD------ 434
            :.|.:..::...::::|.::...|..|.|..:. :....|||:|.|:..||.|..|.:|
Mosquito   299 SNNNLFTINMCEWNTMPLIKSFSLAVNSLSQIP-QCLGRMRRVQFLNFNHNKLTRITIDSFVMLT 362

  Fly   435 VLESL--------------------SSVQEILVDNNRLT------FLAKVNVSFPNLKRVAIEGN 473
            .|.||                    ||::::.:.||.||      :|.|::.......::....:
Mosquito   363 ELRSLHFTSNAIQTVVPASGVNRIPSSLRDVFLTNNLLTRESVANWLRKLDTLDLMYNKIHTLAS 427

  Fly   474 PWQCPCFVKLQHWLATRDVVYLRDNTGYYKGERPLCIVTNVDYCIQNLQAVRRLGILGDFQGEQV 538
            ..||    ..||.|.|   :.||:|                ...|.||:.:..:|:.     |||
Mosquito   428 TLQC----LQQHNLVT---LNLRNN----------------QLRILNLELLPLIGLF-----EQV 464

  Fly   539 E 539
            :
Mosquito   465 D 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	51/165 (31%)
		LRR_8	104..164	CDD:290566	19/61 (31%)
		leucine-rich repeat	106..129	CDD:275380	8/22 (36%)
		leucine-rich repeat	130..153	CDD:275380	9/24 (38%)
		leucine-rich repeat	154..195	CDD:275380	13/49 (27%)
		LRR_RI	194..455	CDD:238064	73/298 (24%)
		LRR_8	194..254	CDD:290566	21/61 (34%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		leucine-rich repeat	220..243	CDD:275380	8/24 (33%)
		leucine-rich repeat	244..267	CDD:275380	5/22 (23%)
		LRR_8	271..330	CDD:290566	16/62 (26%)
		leucine-rich repeat	272..295	CDD:275380	3/22 (14%)
		leucine-rich repeat	296..319	CDD:275380	9/26 (35%)
		LRR_8	319..380	CDD:290566	17/60 (28%)
		leucine-rich repeat	320..343	CDD:275380	6/22 (27%)
		leucine-rich repeat	344..369	CDD:275380	7/24 (29%)
		LRR_8	368..428	CDD:290566	14/59 (24%)
		leucine-rich repeat	370..393	CDD:275380	2/22 (9%)
		leucine-rich repeat	394..417	CDD:275380	4/22 (18%)
		leucine-rich repeat	418..441	CDD:275380	10/48 (21%)
AgaP_AGAP007829	XP_317669.4	leucine-rich repeat	483..506	CDD:275380
		leucine-rich repeat	507..529	CDD:275380
		leucine-rich repeat	530..553	CDD:275380
		LRR_RI	<23..214	CDD:238064	59/226 (26%)
		LRR_8	25..86	CDD:290566	20/60 (33%)
		leucine-rich repeat	27..51	CDD:275380	6/23 (26%)
		leucine-rich repeat	52..75	CDD:275380	8/22 (36%)
		leucine-rich repeat	76..121	CDD:275380	15/48 (31%)
		LRR_8	120..179	CDD:290566	20/62 (32%)
		leucine-rich repeat	122..144	CDD:275380	6/25 (24%)
		leucine-rich repeat	145..168	CDD:275380	7/22 (32%)
		LRR_8	169..229	CDD:290566	19/87 (22%)
		leucine-rich repeat	169..194	CDD:275380	8/24 (33%)
		leucine-rich repeat	195..218	CDD:275380	8/50 (16%)
		leucine-rich repeat	219..242	CDD:275380	9/22 (41%)
		LRR_8	246..303	CDD:290566	17/60 (28%)
		leucine-rich repeat	247..270	CDD:275380	6/22 (27%)
		leucine-rich repeat	293..339	CDD:275380	7/46 (15%)
		leucine-rich repeat	340..363	CDD:275380	7/22 (32%)
		LRR_RI	<387..518	CDD:238064	24/107 (22%)
		leucine-rich repeat	390..412	CDD:275380	5/21 (24%)
		leucine-rich repeat	413..436	CDD:275380	3/26 (12%)
		leucine-rich repeat	437..459	CDD:275380	8/40 (20%)
		leucine-rich repeat	460..482	CDD:275380	3/11 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910