DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6749 and AgaP_AGAP006643

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_316671.4	Gene:	AgaP_AGAP006643 / 1277226	VectorBaseID:	AGAP006643	Length:	951	Species:	Anopheles gambiae

Alignment Length:	552	Identity:	138/552 - (25%)
Similarity:	212/552 - (38%)	Gaps:	154/552 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VLPLLLWLLCMGFPIL-HGADLC-QPIGWRNFQCSEVASLQDLVDLGAENWHTLAIRNVQTELEV 70
            ::|::..:|.....:| .|.::| :|.   :..|.|..:..|....|.            |||.|
Mosquito     5 LVPVIAVVLLGSLALLATGQEVCPEPC---SCDCEESMACVDCSGRGL------------TELPV 54

  Fly    71 GSGENADHLANLLDLDLTGAAPINVHTNGFSIL-------PNLRQLNLSGCGLVDIRGNHFAPES 128
                .||....:|||.          .|.|:.:       |.|..|:||...:..:|.:.....|
Mosquito    55 ----FADFNIEILDLS----------DNLFTTIPPELAQFPRLHYLDLSANAITQLREDALTGMS 105

  Fly   129 ALQRIDFSHNQME----------LLDRDFFGNLRKL-----IYANFSHN---------ALKQCDL 169
            :|..:..|.|.:.          ||..   |||::|     .:.:||.|         :|:..||
Mosquito   106 SLSILILSENNISNWADIHPNQLLLPA---GNLKELRLAKNHFTSFSSNDKSLVLTSLSLRYLDL 167

  Fly   170 PHMPL--------------LNRLELGHNRLVNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGL 220
            ....:              |..|:|..|.:::.:......|:.|.||..:|..|....|.||..|
Mosquito   168 SECKISKVSGSEVIQGLRSLEHLKLSGNPIISMSDMQSTTLKRLELNSCKLSALPPTIFTGLTAL 232

  Fly   221 LELQLSGNRLSSIGL---ETFQPLAQLRKLNLSQNALDALR----PNVFGAVQNFVLHLQQLDLS 278
            .|:.|:.|...|:.|   :|....|.|||:|||...:|.|.    ||:..|:           :.
Mosquito   233 KEVNLARNHRLSLVLPHEDTPVQSASLRKINLSHCNMDTLDLHGFPNLMTAI-----------VR 286

  Fly   279 GNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLN 343
            ||.:|.|..:.|.....|:.||:|.|||:|                        |.|..|..|.:
Mosquito   287 GNMVRQLDRDSFSGTLLLEHLDLSFNSISS------------------------IHPEAFRTLKH 327

  Fly   344 LDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLD 408
            |.|||||:|.:..::.::|..|.|  :..:||:.|.:.....::..|   |.||.:...|:.:||
Mosquito   328 LKTLDLSFNMISRIDGKLFKANDL--LTHINLSRNYISRFSRISADS---LVYLNMSWCEILTLD 387

  Fly   409 VRMFAPMRRLQKLHLGHNLLEEI----------NLDV------------LESLSSVQEILVDNNR 451
            ....|.|..|.:|.|.:|||.:|          .||:            |..|..:..|.:..||
Mosquito   388 WDALASMGELIELDLSNNLLSDIPDTLSSGTLQTLDLSMCRLSTMRNTTLAGLPELVRINLSGNR 452

  Fly   452 LTFLAKVNVSF----PNLKRVAIEGNPWQCPC 479
              |.....|.|    |.|..:.:..|||:|.|
Mosquito   453 --FTTPFRVEFFDKNPFLSEIWLGDNPWRCDC 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	49/200 (25%)
		LRR_8	104..164	CDD:290566	19/83 (23%)
		leucine-rich repeat	106..129	CDD:275380	5/22 (23%)
		leucine-rich repeat	130..153	CDD:275380	8/32 (25%)
		leucine-rich repeat	154..195	CDD:275380	11/68 (16%)
		LRR_RI	194..455	CDD:238064	81/289 (28%)
		LRR_8	194..254	CDD:290566	23/62 (37%)
		leucine-rich repeat	196..219	CDD:275380	9/22 (41%)
		leucine-rich repeat	220..243	CDD:275380	7/25 (28%)
		leucine-rich repeat	244..267	CDD:275380	11/26 (42%)
		LRR_8	271..330	CDD:290566	13/58 (22%)
		leucine-rich repeat	272..295	CDD:275380	5/22 (23%)
		leucine-rich repeat	296..319	CDD:275380	8/22 (36%)
		LRR_8	319..380	CDD:290566	17/60 (28%)
		leucine-rich repeat	320..343	CDD:275380	4/22 (18%)
		leucine-rich repeat	344..369	CDD:275380	10/24 (42%)
		LRR_8	368..428	CDD:290566	16/59 (27%)
		leucine-rich repeat	370..393	CDD:275380	4/22 (18%)
		leucine-rich repeat	394..417	CDD:275380	8/22 (36%)
		leucine-rich repeat	418..441	CDD:275380	11/44 (25%)
AgaP_AGAP006643	XP_316671.4	LRRNT	27..>54	CDD:214470	9/41 (22%)
		LRR_8	59..117	CDD:290566	15/67 (22%)
		LRR_RI	61..387	CDD:238064	94/378 (25%)
		leucine-rich repeat	61..82	CDD:275380	5/30 (17%)
		leucine-rich repeat	83..106	CDD:275380	5/22 (23%)
		leucine-rich repeat	107..134	CDD:275380	5/29 (17%)
		LRR_8	134..197	CDD:290566	13/62 (21%)
		leucine-rich repeat	135..161	CDD:275380	5/25 (20%)
		leucine-rich repeat	162..186	CDD:275380	3/23 (13%)
		leucine-rich repeat	187..231	CDD:275380	13/43 (30%)
		LRR_8	206..269	CDD:290566	23/62 (37%)
		leucine-rich repeat	232..258	CDD:275380	7/25 (28%)
		LRR_8	258..314	CDD:290566	21/66 (32%)
		leucine-rich repeat	259..303	CDD:275380	16/54 (30%)
		LRR_RI	<304..478	CDD:238064	54/204 (26%)
		LRR_8	304..362	CDD:290566	25/83 (30%)
		leucine-rich repeat	304..327	CDD:275380	12/46 (26%)
		leucine-rich repeat	328..347	CDD:275380	7/18 (39%)
		leucine-rich repeat	352..396	CDD:275380	12/46 (26%)
		leucine-rich repeat	397..418	CDD:275380	7/20 (35%)
		LRR_8	399..453	CDD:290566	13/55 (24%)
		leucine-rich repeat	419..440	CDD:275380	3/20 (15%)
		TPKR_C2	476..>515	CDD:301599	5/7 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910