DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and AgaP_AGAP005962

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_316002.4	Gene:	AgaP_AGAP005962 / 1276633	VectorBaseID:	AGAP005962	Length:	830	Species:	Anopheles gambiae

Alignment Length:	552	Identity:	135/552 - (24%)
Similarity:	214/552 - (38%)	Gaps:	142/552 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 CQPIGWRN---FQCSEVAS-------LQD----------------LVDLGAEN-WH-TLAIRNVQ 65
            |.|..:.|   .:|.::.|       |||                |:||.|.: |. .:.|::::
Mosquito    30 CSPGLFANNIDVKCEQMESFGQVVNALQDRFTEDHNIWLTISHSQLLDLAALSFWEMNMNIKSLR 94

  Fly    66 TELEVGSGENADHL-----ANLLDLDLTGAAP---INVHTNGFSILPNLRQLNLSGCGLVDIRGN 122
            ...     :|..||     .||..|||..||.   ..:..:.|..:|||..|:::...:..|.|:
Mosquito    95 INF-----DNLSHLPVSSFRNLPRLDLFSAADNLLEEIPPDMFEQMPNLGTLDMARSRIRYISGD 154

  Fly   123 HFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYA-NFSHNALKQCD--LPHMPLLNRLELGHNR 184
            .|.....|:.:...:||::.:|.|   .|.|.|:: ..|.|.|:..:  :.|:..|..|.:..|.
Mosquito   155 TFRHLQNLRHLIMGNNQLQRIDTD---ALPKTIHSLQLSVNQLRSLNGSIRHLDELKLLFINENN 216

  Fly   185 LVNATFGV---CPQLQELILNDNQLIQL---------------DVNAFRGLHGLL-------ELQ 224
            |......:   .|.|..:...:|||.||               ..|..|.|.|||       :|.
Mosquito   217 LTTLDGELPLGSPNLMMITAQNNQLEQLPGELRFLKNLDNLCVPGNRLRSLDGLLARATHLTKLL 281

  Fly   225 LSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGA------------VQNFVLH------ 271
            ...|::|.:..:.|....:|.:|||:.|.|..|..::...            :|.|.|.
Mosquito   282 AQDNQISELRRDEFLEAERLEELNLAGNWLVNLNGSLLNCKGLINANFSENRLQEFSLQEVAGLR 346

  Fly   272 -LQQLDLSGNRIRLL---FDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILE 332
             |:.||||.|||.:|   .:|.......:..|.::.|.:.||..| .:||.:||.|.:.:|.:..
Mosquito   347 KLRLLDLSHNRIEVLSGRMENMIDSGLIISELRLNNNRLRSLDGA-LMGLNNLRILNVAHNELQT 410

  Fly   333 IKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYL 397
            |.|.....:..|:.||||:|.|:.|||  .....||.:..||.:.|::..:|. .|..||.
Mosquito   411 ITPNDLIGMEELERLDLSFNQLKTLEE--LSKTFLPSLESLNASYNQLTTMHK-DFHGLPI---- 468

  Fly   398 KLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLAKVNVSF 462
                                |....|..|::.|:::|           ||.|.|.:     |...
Mosquito   469 --------------------LCVADLSKNMIRELSVD-----------LVSNTRCS-----NHGV 497

  Fly   463 PNLKRVAIEGNPWQC----PCFVKLQHWLATR 490
            ||...:.::.||..|    |..:....:..||
Mosquito   498 PNRLEIFLDENPVLCNESLPELINQMEFYHTR 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	46/180 (26%)
		LRR_8	104..164	CDD:290566	17/60 (28%)
		leucine-rich repeat	106..129	CDD:275380	5/22 (23%)
		leucine-rich repeat	130..153	CDD:275380	6/22 (27%)
		leucine-rich repeat	154..195	CDD:275380	9/46 (20%)
		LRR_RI	194..455	CDD:238064	78/304 (26%)
		LRR_8	194..254	CDD:290566	22/81 (27%)
		leucine-rich repeat	196..219	CDD:275380	9/37 (24%)
		leucine-rich repeat	220..243	CDD:275380	6/29 (21%)
		leucine-rich repeat	244..267	CDD:275380	7/34 (21%)
		LRR_8	271..330	CDD:290566	21/68 (31%)
		leucine-rich repeat	272..295	CDD:275380	10/25 (40%)
		leucine-rich repeat	296..319	CDD:275380	7/22 (32%)
		LRR_8	319..380	CDD:290566	21/60 (35%)
		leucine-rich repeat	320..343	CDD:275380	6/22 (27%)
		leucine-rich repeat	344..369	CDD:275380	11/24 (46%)
		LRR_8	368..428	CDD:290566	11/59 (19%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	0/22 (0%)
		leucine-rich repeat	418..441	CDD:275380	5/22 (23%)
AgaP_AGAP005962	XP_316002.4	leucine-rich repeat	67..89	CDD:275380	5/21 (24%)
		leucine-rich repeat	90..113	CDD:275380	6/27 (22%)
		LRR_8	109..172	CDD:290566	17/62 (27%)
		leucine-rich repeat	114..137	CDD:275380	6/22 (27%)
		leucine-rich repeat	138..161	CDD:275380	5/22 (23%)
		LRR_RI	157..408	CDD:238064	64/254 (25%)
		leucine-rich repeat	162..183	CDD:275380	6/23 (26%)
		leucine-rich repeat	184..206	CDD:275380	5/21 (24%)
		leucine-rich repeat	207..230	CDD:275380	4/22 (18%)
		leucine-rich repeat	231..253	CDD:275380	6/21 (29%)
		leucine-rich repeat	254..276	CDD:275380	6/21 (29%)
		leucine-rich repeat	277..300	CDD:275380	4/22 (18%)
		LRR_8	300..358	CDD:290566	16/57 (28%)
		leucine-rich repeat	301..347	CDD:275380	10/45 (22%)
		leucine-rich repeat	324..339	CDD:275380	2/14 (14%)
		leucine-rich repeat	348..373	CDD:275380	10/24 (42%)
		leucine-rich repeat	375..397	CDD:275380	7/22 (32%)
		LRR_8	377..432	CDD:290566	19/55 (35%)
		LRR_4	397..440	CDD:289563	16/44 (36%)
		leucine-rich repeat	398..421	CDD:275380	6/22 (27%)
		LRR_8	421..479	CDD:290566	22/84 (26%)
		leucine-rich repeat	422..445	CDD:275380	11/24 (46%)
		leucine-rich repeat	446..466	CDD:275380	5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910