DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and AgaP_AGAP005693

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_315704.4	Gene:	AgaP_AGAP005693 / 1276366	VectorBaseID:	AGAP005693	Length:	437	Species:	Anopheles gambiae

Alignment Length:	399	Identity:	104/399 - (26%)
Similarity:	174/399 - (43%)	Gaps:	73/399 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 LTGAAPINVHTNGFSILPNLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQM-ELLDRDFFGN 150
            |||..|..     |...|.|..||.:|..:..|:..:||....||.:....|:: :|.|..|||.
Mosquito    69 LTGIPPAM-----FQTFPKLESLNATGSDIKQIQSRNFADAKTLQSLYLRGNKIHDLPDVAFFGA 128

  Fly   151 LRKLIYANFSHNALKQCDLPHMPLLNRLELGHNRLVNATFGVCPQLQELILNDNQLIQLDVNAFR 215
            .|                                           ||.|.|:||.:..::..||:
Mosquito   129 SR-------------------------------------------LQTLDLSDNAIATIESTAFK 150

  Fly   216 GLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGN 280
            .|..|..|.|..|.|:.:....|..|:.|.:|.|.||.|.::...:|....:    |..|::|.|
Mosquito   151 RLRELKTLLLGSNSLTELQPGVFDDLSDLERLELQQNGLGSIDDRLFQGCHS----LTALNVSHN 211

  Fly   281 RIRLLFDNQFRVLARLQMLDVSRN--SIASLSPAHFVGLGSLRKLYLQYNAILEIK-PATFAALL 342
            .::.....||.......::|.|.|  |:..:.|       :||:|....|.|..:: .||..:.|
Mosquito   212 ALKTFNVAQFERRWSFDLIDASYNKLSVVRIPP-------NLRQLVAIGNGIRTVESTATNGSEL 269

  Fly   343 NLDTLDLSYNNLEFLEE-QIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKS 406
            .|  |.|.:|.|..::| .:|     .::..|:|:.||::.....:.:....|..|||..|:|:|
Mosquito   270 IL--LKLPHNKLTSVDEVPVF-----DKLITLDLSFNRIREFDFRSAARFGKLVLLKLDGNQLES 327

  Fly   407 LDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLAKVNV--SFPNLKRVA 469
            :...:.||:..|:.:||..|....::|:||.::..:.::.:..|:|..||..::  |||.:.|:.
Mosquito   328 VSNSLTAPITHLKYVHLADNQFTHLDLNVLRTVPRILKLDLRRNQLERLAVTDLAGSFPVMVRIM 392

  Fly   470 IEGNPWQCP 478
            :|||.::||
Mosquito   393 LEGNRFRCP 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	39/153 (25%)
		LRR_8	104..164	CDD:290566	17/60 (28%)
		leucine-rich repeat	106..129	CDD:275380	7/22 (32%)
		leucine-rich repeat	130..153	CDD:275380	8/23 (35%)
		leucine-rich repeat	154..195	CDD:275380	0/40 (0%)
		LRR_RI	194..455	CDD:238064	71/264 (27%)
		LRR_8	194..254	CDD:290566	21/59 (36%)
		leucine-rich repeat	196..219	CDD:275380	9/22 (41%)
		leucine-rich repeat	220..243	CDD:275380	7/22 (32%)
		leucine-rich repeat	244..267	CDD:275380	7/22 (32%)
		LRR_8	271..330	CDD:290566	15/60 (25%)
		leucine-rich repeat	272..295	CDD:275380	6/22 (27%)
		leucine-rich repeat	296..319	CDD:275380	5/24 (21%)
		LRR_8	319..380	CDD:290566	18/62 (29%)
		leucine-rich repeat	320..343	CDD:275380	7/23 (30%)
		leucine-rich repeat	344..369	CDD:275380	7/25 (28%)
		LRR_8	368..428	CDD:290566	17/59 (29%)
		leucine-rich repeat	370..393	CDD:275380	4/22 (18%)
		leucine-rich repeat	394..417	CDD:275380	9/22 (41%)
		leucine-rich repeat	418..441	CDD:275380	7/22 (32%)
AgaP_AGAP005693	XP_315704.4	LRR_8	57..117	CDD:290566	16/52 (31%)
		leucine-rich repeat	59..82	CDD:275380	5/17 (29%)
		leucine-rich repeat	83..106	CDD:275380	7/22 (32%)
		LRR_8	105..165	CDD:290566	22/102 (22%)
		LRR_4	105..146	CDD:289563	15/83 (18%)
		leucine-rich repeat	107..130	CDD:275380	8/22 (36%)
		LRR_RI	131..398	CDD:238064	80/284 (28%)
		leucine-rich repeat	131..154	CDD:275380	9/22 (41%)
		LRR_8	153..213	CDD:290566	18/63 (29%)
		leucine-rich repeat	155..178	CDD:275380	7/22 (32%)
		leucine-rich repeat	179..202	CDD:275380	7/22 (32%)
		leucine-rich repeat	203..226	CDD:275380	6/22 (27%)
		leucine-rich repeat	227..268	CDD:275380	12/47 (26%)
		leucine-rich repeat	269..290	CDD:275380	8/27 (30%)
		LRR_8	272..325	CDD:290566	15/57 (26%)
		leucine-rich repeat	291..314	CDD:275380	4/22 (18%)
		leucine-rich repeat	315..338	CDD:275380	9/22 (41%)
		leucine-rich repeat	339..358	CDD:275380	6/18 (33%)
		leucine-rich repeat	363..383	CDD:275380	4/19 (21%)
		leucine-rich repeat	388..400	CDD:275378	4/11 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910