DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and AgaP_AGAP008593

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_314696.4	Gene:	AgaP_AGAP008593 / 1275449	VectorBaseID:	AGAP008593	Length:	604	Species:	Anopheles gambiae

Alignment Length:	468	Identity:	122/468 - (26%)
Similarity:	195/468 - (41%)	Gaps:	97/468 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 GAAPINVHTNGFSILPNLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDF---FGN 150
            |||.|.:.....::       :|:.|.:.|:|......::.|. |..:|..::.|....   |.:
Mosquito    27 GAADIELDEANDAV-------SLTACYVEDLRNIREHSQNPLV-IQINHCYLQELPNAIFIRFTD 83

  Fly   151 LRKLIYANFSHNALKQCDLPHMPLLNRLELGHNRLV------NATFGVCPQLQELILNDNQLIQL 209
            |:.|...:...|.|:...|..:..:..|.|..|.|.      :...|.   ||.|.|..|.:..:
Mosquito    84 LKVLEICDSRVNNLQDFALNGLRNIESLNLSRNNLTTIKSWSDHDLGT---LQVLDLRRNLIRSI 145

  Fly   210 DVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALD----------------ALR 258
            |..:|:...||::|.|:.|.::::...||:|:|.|:.|||.:|.|.                |..
Mosquito   146 DELSFQRYPGLVKLSLAVNFITTVPDGTFKPVANLKNLNLGKNLLTTIEEGTLRGLNKLTHVAFH 210

  Fly   259 PNVFGAVQNFVL----HLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGS 319
            .|....:..|..    ||:.|.|.||::.....:.|..|.||..|:||.|.:.::....|...|.
Mosquito   211 HNRIRTIHPFAFVGNGHLKVLQLQGNQLGSFEPDLFGNLPRLTFLNVSSNELETVGNLSFKNSGD 275

  Fly   320 LRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQI-----------FGGNTL------ 367
            ||.|.|.||.|..::..:|..|.:|:.|::|:|.|..:.:.:           ..||.|
Mosquito   276 LRVLDLSYNRIGLLEDNSFKGLYDLEALNVSHNQLATVSKYVLKDCANLRDLDLSGNRLDYVGLK 340

  Fly   368 -----PRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNL 427
                 ||:.||||:.|.:..:....|..||.|..|.|.||:|.. |..:::.| .|..|::..|.
Mosquito   341 LSSATPRLVRLNLSRNAIGEIERDVFEDLPKLHTLDLAHNQLTD-DAFLWSLM-NLSVLNMSQNG 403

  Fly   428 LEEINLDVLESLSSVQEILVDNNRLTFLAKVNVSFPNLKRVAIEGNPWQCPCFV-KLQHWLATRD 491
            ..:||..:||||:..:  |.|                        |||.|...| :|.|  .:..
Mosquito   404 FRKINASLLESLTLAE--LYD------------------------NPWDCRFLVQELAH--HSSS 440

  Fly   492 VV----YLRDNTG 500
            |:    ||.::||
Mosquito   441 VIYGKNYLVEDTG 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	41/177 (23%)
		LRR_8	104..164	CDD:290566	12/62 (19%)
		leucine-rich repeat	106..129	CDD:275380	4/22 (18%)
		leucine-rich repeat	130..153	CDD:275380	6/25 (24%)
		leucine-rich repeat	154..195	CDD:275380	9/46 (20%)
		LRR_RI	194..455	CDD:238064	87/302 (29%)
		LRR_8	194..254	CDD:290566	21/59 (36%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		leucine-rich repeat	220..243	CDD:275380	7/22 (32%)
		leucine-rich repeat	244..267	CDD:275380	8/38 (21%)
		LRR_8	271..330	CDD:290566	22/58 (38%)
		leucine-rich repeat	272..295	CDD:275380	7/22 (32%)
		leucine-rich repeat	296..319	CDD:275380	6/22 (27%)
		LRR_8	319..380	CDD:290566	24/82 (29%)
		leucine-rich repeat	320..343	CDD:275380	9/22 (41%)
		leucine-rich repeat	344..369	CDD:275380	8/46 (17%)
		LRR_8	368..428	CDD:290566	21/59 (36%)
		leucine-rich repeat	370..393	CDD:275380	7/22 (32%)
		leucine-rich repeat	394..417	CDD:275380	8/22 (36%)
		leucine-rich repeat	418..441	CDD:275380	9/22 (41%)
AgaP_AGAP008593	XP_314696.4	LRR_8	84..142	CDD:290566	15/60 (25%)
		leucine-rich repeat	84..107	CDD:275380	5/22 (23%)
		LRR_4	107..149	CDD:289563	11/44 (25%)
		leucine-rich repeat	109..131	CDD:275380	4/21 (19%)
		leucine-rich repeat	132..155	CDD:275380	7/22 (32%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		LRR_8	179..238	CDD:290566	15/58 (26%)
		leucine-rich repeat	180..203	CDD:275380	6/22 (27%)
		leucine-rich repeat	204..227	CDD:275380	3/22 (14%)
		LRR_RI	227..>424	CDD:238064	62/224 (28%)
		LRR_8	227..286	CDD:290566	22/58 (38%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..275	CDD:275380	6/22 (27%)
		LRR_8	276..334	CDD:290566	16/57 (28%)
		leucine-rich repeat	276..299	CDD:275380	9/22 (41%)
		leucine-rich repeat	300..323	CDD:275380	5/22 (23%)
		LRR_8	323..382	CDD:290566	18/58 (31%)
		leucine-rich repeat	324..347	CDD:275380	3/22 (14%)
		leucine-rich repeat	348..369	CDD:275380	6/20 (30%)
		leucine-rich repeat	372..393	CDD:275380	8/22 (36%)
		leucine-rich repeat	394..415	CDD:275380	7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910