DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and AgaP_AGAP000054

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_311104.5	Gene:	AgaP_AGAP000054 / 1272222	VectorBaseID:	AGAP000054	Length:	1593	Species:	Anopheles gambiae

Alignment Length:	571	Identity:	144/571 - (25%)
Similarity:	218/571 - (38%)	Gaps:	126/571 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 ENWHTLAIRNVQTELEVGSGENADHLANLLDLDLTGAAPINVHTNGFSILPNLRQLNLSGCGLVD 118
            :|.|: ::.||..|:        ...:|.|:..|..|..|.....||..|..||:|.||...::.
Mosquito    19 DNRHS-SLPNVPEEI--------FRYSNSLEELLLDANHIRDLPKGFFRLYRLRKLGLSDNDIIK 74

  Fly   119 IRGN--HFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNALKQCDLPHMPLLNRLELG 181
            |..:  :|.   .|..:|.|.|::..:..| ..:||.|..|:||.|.           ::||..|
Mosquito    75 IPSDIQNFV---NLVELDVSRNEIGDIPED-IKHLRSLQIADFSSNP-----------ISRLPAG 124

  Fly   182 HNRLVNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRK 246
            ..:|.|.|.        |.|||..||.|..: |..|..|:.|:|..|.|.::. |:...|.:|.:
Mosquito   125 FTQLRNLTV--------LGLNDMSLISLPQD-FGCLSKLVSLELRENLLKNLP-ESISQLTKLER 179

  Fly   247 LNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSP 311
            |:|..|.:|.|..:|     .::..||:|.|..|:: |....:..:|.:|..||||.|.:..| |
Mosquito   180 LDLGDNEIDELPSHV-----GYLPSLQELWLDHNQL-LRLPPEIGLLKKLVCLDVSENRLEEL-P 237

  Fly   312 AHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLN 376
            ....||..|..|:|..| :||..|...:.|.||..|.|..|.|..|.:.|   .....|:.|.|.
Mosquito   238 EEIGGLECLTDLHLSQN-LLETLPNGISKLTNLSILKLDQNRLHTLNDSI---GCCVHMQELILT 298

  Fly   377 GNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSS 441
            .|.:..| |....::..|..|.:..|.|.::...: ...|:|..|.|..|.|..:..: |.:...
Mosquito   299 ENFLSEL-PATVGNMLVLNNLNVDRNSLVAVPSEL-GNCRQLGVLSLRENKLTRLPAE-LGNCGE 360

  Fly   442 VQEILVDNNRLTFL--AKVNVSFPNLKRVAIEGNPWQ-----------------CPCFVKLQ--- 484
            :..:.|..|.|..|  :.||:   .||.|.:..|..|                 ..||:..|
Mosquito   361 LHVLDVSGNLLQHLPYSLVNL---QLKAVWLSENQSQPVPTFQPDVDETTNEQVLTCFLLPQQRY 422

  Fly   485 --------------HWL-----------------ATRDVVYLRDNTGY-----YKGERPLCIVTN 513
                          :|.                 |.||..::|.||.:     .|..:.......
Mosquito   423 VPSNPSQREDTDSENWEEREASRTHSVKFTEDFGADRDTPFVRQNTPHPKELKMKAHKLFAKERK 487

  Fly   514 VDYCIQNL-----QAVRRLGILG----------DFQGEQVEADAFDDDASA 549
            .|....||     ::..|..:|.          |.||..:..|....:|:|
Mosquito   488 SDDLSGNLDTLSEESASRPSLLNRSGYGTATMEDIQGHAIPHDEEQGEAAA 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	46/154 (30%)
		LRR_8	104..164	CDD:290566	19/61 (31%)
		leucine-rich repeat	106..129	CDD:275380	7/24 (29%)
		leucine-rich repeat	130..153	CDD:275380	6/22 (27%)
		leucine-rich repeat	154..195	CDD:275380	11/40 (28%)
		LRR_RI	194..455	CDD:238064	76/260 (29%)
		LRR_8	194..254	CDD:290566	20/59 (34%)
		leucine-rich repeat	196..219	CDD:275380	9/22 (41%)
		leucine-rich repeat	220..243	CDD:275380	7/22 (32%)
		leucine-rich repeat	244..267	CDD:275380	7/22 (32%)
		LRR_8	271..330	CDD:290566	21/58 (36%)
		leucine-rich repeat	272..295	CDD:275380	7/22 (32%)
		leucine-rich repeat	296..319	CDD:275380	10/22 (45%)
		LRR_8	319..380	CDD:290566	20/60 (33%)
		leucine-rich repeat	320..343	CDD:275380	8/22 (36%)
		leucine-rich repeat	344..369	CDD:275380	7/24 (29%)
		LRR_8	368..428	CDD:290566	15/59 (25%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	4/22 (18%)
		leucine-rich repeat	418..441	CDD:275380	6/22 (27%)
AgaP_AGAP000054	XP_311104.5	leucine-rich repeat	16..38	CDD:275380	5/27 (19%)
		LRR_RI	23..259	CDD:238064	82/277 (30%)
		LRR_8	38..95	CDD:290566	18/59 (31%)
		leucine-rich repeat	39..58	CDD:275380	6/18 (33%)
		leucine-rich repeat	62..84	CDD:275380	7/24 (29%)
		LRR_8	84..138	CDD:290566	20/73 (27%)
		leucine-rich repeat	85..107	CDD:275380	6/22 (27%)
		leucine-rich repeat	108..130	CDD:275380	9/32 (28%)
		leucine-rich repeat	131..176	CDD:275380	17/54 (31%)
		LRR_8	152..210	CDD:290566	19/63 (30%)
		leucine-rich repeat	177..199	CDD:275380	7/26 (27%)
		LRR_8	198..256	CDD:290566	21/60 (35%)
		leucine-rich repeat	200..222	CDD:275380	7/22 (32%)
		leucine-rich repeat	223..245	CDD:275380	10/22 (45%)
		LRR_8	246..300	CDD:290566	19/57 (33%)
		leucine-rich repeat	246..268	CDD:275380	8/22 (36%)
		LRR_8	315..371	CDD:290566	13/57 (23%)
		leucine-rich repeat	315..337	CDD:275380	4/22 (18%)
		leucine-rich repeat	361..382	CDD:275380	6/23 (26%)
		PDZ	766..854	CDD:214570
		PDZ_signaling	943..1032	CDD:238492
		PDZ_signaling	1139..1228	CDD:238492
		PDZ_signaling	1238..1327	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910