DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6749 and TOLL10

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_309458.4	Gene:	TOLL10 / 1270739	VectorBaseID:	AGAP011187	Length:	1347	Species:	Anopheles gambiae

Alignment Length:	575	Identity:	158/575 - (27%)
Similarity:	254/575 - (44%)	Gaps:	91/575 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WVLPLLLWLLCMGFPILHGADLCQPIGWRNFQCSEVASLQDLVDLGAENW---HTLAIRNVQTEL 68
            |.||..::  |..|.:.| .:|.     ||       .|.|:..||..:|   .|...:...|.|
Mosquito   181 WALPTDVF--CPLFSLRH-LNLT-----RN-------RLTDVSQLGFSDWGNGPTAPGKACNTGL 230

  Fly    69 EVGSGENADHLANLLDLDLTGAAPINV-----------HTNGFSILPNLRQLNLSGCGLVDIRGN 122
            ||....:.|.|| |.|..|:....::|           ....|..|.:|:.||:|...||.:...
Mosquito   231 EVLDLSHNDLLA-LPDNGLSSLRSLSVLMLQDNLLTALADRSFVGLGSLKVLNMSSNKLVALPPE 294

  Fly   123 HFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNAL-----KQCDLPHMPLLNRLELGH 182
            .|.....|::|...:|.:.:|.......|.:|...:.|||.|     |:.....|..|..||:.|
Mosquito   295 TFQSTRELRQIYLQNNSLSVLAPGMLEGLDRLEILDLSHNELTSEWVKRNTFAGMKRLVVLEIAH 359

  Fly   183 NRLVNA---TFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQL 244
            |.|...   .|.....||.|.|..||:..:..|||..|..|:.|.||.|||..|....|..|..|
Mosquito   360 NALTKIDRHVFRELYSLQILNLEANQIESIADNAFSDLKNLVALTLSHNRLKRIEQHHFSELYVL 424

  Fly   245 RKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASL 309
            .:|.:..|.::::...   |::| :.:|..|:|:.||:..:.:...: |..|:.||:.:|.|:::
Mosquito   425 NQLYVESNLIESMHGR---ALEN-LTNLNDLNLNDNRLTEIPEGLGK-LRFLKSLDLGKNRISAV 484

  Fly   310 SPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLN 374
            |.|.|.||..|..|.|..|.|..|....|..|.:|..|:|:.|.:..:::..|..|  |.:|.:.
Mosquito   485 SNASFEGLEQLLGLRLVENRITNISRDAFVTLSSLHVLNLASNQIRHIDQSAFSSN--PTIRAIR 547

  Fly   375 LNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEIN------- 432
            |:.|.::.:..: |:|||.|.:|.:..|:::..|...| |: .|:.|.:..|.:.|:.
Mosquito   548 LDNNELEDISGV-FTSLPALVFLNVSDNQIRLFDYSHF-PV-SLEWLDMHQNNITELGNYYDLNN 609

  Fly   433 -----LDV----LESL------SSVQEILVDNNRL------TFLAKVNVSFPNLKRVAIEGNPWQ 476
                 |||    |.|:      .|::.:.::||.|      |||:|     .:|::|.:.||..:
Mosquito   610 LQIKMLDVSFNRLTSVDAKCIPDSIETLFLNNNALEEVAAGTFLSK-----RSLEKVVLYGNYLR 669

  Fly   477 CPCFVKLQ-HWLATRDVVYLRDNTGYYKGERPLCIVTNVDYCIQNLQAVRRLGIL 530
                 ||: ..||...|...|:...:|.|:.|:    :.|..::.||.:.:|..|
Mosquito   670 -----KLEIGALALTRVADDREVPAFYLGDNPI----HCDCTMEWLQGINKLAHL 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	50/160 (31%)
		LRR_8	104..164	CDD:290566	16/59 (27%)
		leucine-rich repeat	106..129	CDD:275380	7/22 (32%)
		leucine-rich repeat	130..153	CDD:275380	5/22 (23%)
		leucine-rich repeat	154..195	CDD:275380	14/48 (29%)
		LRR_RI	194..455	CDD:238064	83/288 (29%)
		LRR_8	194..254	CDD:290566	23/59 (39%)
		leucine-rich repeat	196..219	CDD:275380	10/22 (45%)
		leucine-rich repeat	220..243	CDD:275380	10/22 (45%)
		leucine-rich repeat	244..267	CDD:275380	4/22 (18%)
		LRR_8	271..330	CDD:290566	20/58 (34%)
		leucine-rich repeat	272..295	CDD:275380	6/22 (27%)
		leucine-rich repeat	296..319	CDD:275380	10/22 (45%)
		LRR_8	319..380	CDD:290566	18/60 (30%)
		leucine-rich repeat	320..343	CDD:275380	8/22 (36%)
		leucine-rich repeat	344..369	CDD:275380	6/24 (25%)
		LRR_8	368..428	CDD:290566	17/59 (29%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	6/22 (27%)
		leucine-rich repeat	418..441	CDD:275380	9/44 (20%)
TOLL10	XP_309458.4	LRR_RI	94..364	CDD:238064	53/198 (27%)
		leucine-rich repeat	116..139	CDD:275380
		LRR_8	140..204	CDD:290566	9/37 (24%)
		leucine-rich repeat	170..193	CDD:275380	4/13 (31%)
		LRR_8	193..288	CDD:290566	27/108 (25%)
		leucine-rich repeat	194..229	CDD:275380	10/47 (21%)
		leucine-rich repeat	230..253	CDD:275380	9/23 (39%)
		leucine-rich repeat	254..277	CDD:275380	3/22 (14%)
		LRR_8	277..336	CDD:290566	16/58 (28%)
		leucine-rich repeat	278..301	CDD:275380	7/22 (32%)
		leucine-rich repeat	302..325	CDD:275380	5/22 (23%)
		leucine-rich repeat	326..351	CDD:275380	7/24 (29%)
		LRR_8	350..410	CDD:290566	22/59 (37%)
		leucine-rich repeat	352..375	CDD:275380	7/22 (32%)
		LRR_4	375..414	CDD:289563	17/38 (45%)
		leucine-rich repeat	376..399	CDD:275380	10/22 (45%)
		LRR_8	398..>441	CDD:290566	13/45 (29%)
		leucine-rich repeat	400..470	CDD:275380	21/74 (28%)
		LRR_RI	<462..697	CDD:238064	68/250 (27%)
		LRR_8	471..529	CDD:290566	22/57 (39%)
		leucine-rich repeat	471..494	CDD:275380	10/22 (45%)
		leucine-rich repeat	495..518	CDD:275380	8/22 (36%)
		LRR_8	517..576	CDD:290566	17/61 (28%)
		leucine-rich repeat	519..542	CDD:275380	6/24 (25%)
		leucine-rich repeat	543..563	CDD:275380	4/20 (20%)
		leucine-rich repeat	566..587	CDD:275380	6/22 (27%)
		LRR_8	587..644	CDD:290566	12/56 (21%)
		leucine-rich repeat	610..633	CDD:275380	5/22 (23%)
		leucine-rich repeat	634..657	CDD:275380	7/27 (26%)
		leucine-rich repeat	658..677	CDD:275380	6/23 (26%)
		TPKR_C2	695..752	CDD:301599	6/25 (24%)
		leucine-rich repeat	813..834	CDD:275378
		LRR_8	833..893	CDD:290566
		LRR_4	833..876	CDD:289563
		leucine-rich repeat	835..858	CDD:275378
		LRR_RI	<852..957	CDD:238064
		leucine-rich repeat	859..882	CDD:275378
		leucine-rich repeat	883..906	CDD:275378
		leucine-rich repeat	907..918	CDD:275378
		TIR_2	1086..1224	CDD:304906
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910