DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and AgaP_AGAP011227

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_309417.4	Gene:	AgaP_AGAP011227 / 1270698	VectorBaseID:	AGAP011227	Length:	394	Species:	Anopheles gambiae

Alignment Length:	388	Identity:	116/388 - (29%)
Similarity:	173/388 - (44%)	Gaps:	57/388 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 PNLRQLNLSGCGLVDIRGNHF--APESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNALKQ 166
            |::|.|||:...:.::   ||  |....|:.:|.|||:::.|....|.:..||:..|.:||.|..
Mosquito    56 PDVRYLNLTANQITNV---HFTLAFYYQLESLDLSHNRLDTLGSKNFESQEKLLALNLTHNVLPA 117

  Fly   167 CDLPHMPLLNRLELGHNRLVNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLS 231
            ........|.||||                  |.|.||||.|:...||:.|..|..|:|..|||.
Mosquito   118 LLKDSFRGLRRLEL------------------LRLGDNQLEQIHPTAFQSLVSLRRLELPSNRLV 164

  Fly   232 SIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARL 296
            |......:||..|..|.|:.|.|..:   .:|....::..|:.||||||.|..:.::.|..|.:|
Mosquito   165 SFEEGVLRPLVSLDTLLLANNQLLEV---PYGGNLEYLRSLRHLDLSGNLIEFVANDSFGTLHQL 226

  Fly   297 QMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQI 361
            ..|.::.|.:..|..:.|.||.:|:.|.|..|.:..|.....|.|.||.||.||.|:  |:|...
Mosquito   227 HTLRLAGNVLMELDWSGFSGLSALQLLDLADNNLTTIPTVQLAKLYNLTTLTLSGNS--FVELPP 289

  Fly   362 FGGNTLPRMRRLNLNG-NRMKHLHPLAFSSLPFLEYLKLGHN-ELKSLDVRMFAPMRRLQKLHLG 424
            .....|.::|.|:|:. :|::|:...||.....|:.|.|..| ...:|.||:|         |..
Mosquito   290 VAFQNLFQLRELHLDRLDRLEHIDTRAFIDNTHLQVLTLDDNPSFSTLPVRLF---------HGN 345

  Fly   425 HNLLEEINLDVLESLSSVQEILVDNNRLTFLAKVNVSFPNLKRVAIEGNPWQCPCFVKLQHWL 487
            .:|:               :|.:..|.|..|..|......|:|:.:.|||..|.|.::   ||
Mosquito   346 PHLI---------------DISMRRNALLTLDAVQFPLDRLQRLKLAGNPLVCNCTIR---WL 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	50/153 (33%)
		LRR_8	104..164	CDD:290566	20/61 (33%)
		leucine-rich repeat	106..129	CDD:275380	7/24 (29%)
		leucine-rich repeat	130..153	CDD:275380	7/22 (32%)
		leucine-rich repeat	154..195	CDD:275380	10/40 (25%)
		LRR_RI	194..455	CDD:238064	79/262 (30%)
		LRR_8	194..254	CDD:290566	23/59 (39%)
		leucine-rich repeat	196..219	CDD:275380	10/22 (45%)
		leucine-rich repeat	220..243	CDD:275380	9/22 (41%)
		leucine-rich repeat	244..267	CDD:275380	6/22 (27%)
		LRR_8	271..330	CDD:290566	21/58 (36%)
		leucine-rich repeat	272..295	CDD:275380	10/22 (45%)
		leucine-rich repeat	296..319	CDD:275380	7/22 (32%)
		LRR_8	319..380	CDD:290566	20/61 (33%)
		leucine-rich repeat	320..343	CDD:275380	7/22 (32%)
		leucine-rich repeat	344..369	CDD:275380	9/24 (38%)
		LRR_8	368..428	CDD:290566	16/61 (26%)
		leucine-rich repeat	370..393	CDD:275380	7/23 (30%)
		leucine-rich repeat	394..417	CDD:275380	8/23 (35%)
		leucine-rich repeat	418..441	CDD:275380	2/22 (9%)
AgaP_AGAP011227	XP_309417.4	leucine-rich repeat	58..80	CDD:275380	7/24 (29%)
		LRR_8	80..163	CDD:290566	32/100 (32%)
		leucine-rich repeat	81..104	CDD:275380	7/22 (32%)
		leucine-rich repeat	105..152	CDD:275380	20/64 (31%)
		leucine-rich repeat	153..176	CDD:275380	9/22 (41%)
		leucine-rich repeat	177..201	CDD:275380	6/26 (23%)
		LRR_8	200..260	CDD:290566	21/59 (36%)
		leucine-rich repeat	202..225	CDD:275380	10/22 (45%)
		leucine-rich repeat	226..249	CDD:275380	7/22 (32%)
		LRR_8	250..305	CDD:290566	20/56 (36%)
		leucine-rich repeat	250..273	CDD:275380	7/22 (32%)
		leucine-rich repeat	274..297	CDD:275380	9/24 (38%)
		leucine-rich repeat	298..322	CDD:275380	7/23 (30%)
		LRR_8	321..381	CDD:290566	19/83 (23%)
		leucine-rich repeat	323..344	CDD:275380	8/29 (28%)
		leucine-rich repeat	348..370	CDD:275380	6/36 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910