DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and AgaP_AGAP011229

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_309414.4	Gene:	AgaP_AGAP011229 / 1270695	VectorBaseID:	AGAP011229	Length:	398	Species:	Anopheles gambiae

Alignment Length:	348	Identity:	109/348 - (31%)
Similarity:	162/348 - (46%)	Gaps:	32/348 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 YANFSHNALKQCDLPHMPL-----LNRLELGHNR---LVNATFGVCPQLQELILNDNQLIQLDVN 212
            |.|.:.|.:...   |..|     |..|:|..||   |.:..|.....|:.|.|:||.::.:..:
Mosquito    64 YINLTANRITNV---HFTLTFYYKLEVLDLAGNRIEALGSRNFDTQQALRTLNLSDNAIVSIPKD 125

  Fly   213 AFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLD- 276
            |||||..|..|:|.|||:.:|....|..|..|.:|:|..|||.:|.|:.       :.||..|:
Mosquito   126 AFRGLQRLQTLKLCGNRIDTIHPAAFHDLRNLIELDLEGNALTSLEPST-------LRHLYSLEV 183

  Fly   277 LSGNRIRLL---FDNQFRVLA-RLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPAT 337
            ||....:||   ::.....|. |||:||:|.|.:..::...||.|..||.|.|..|.:.|:....
Mosquito   184 LSFQNNQLLEVPYERNLEHLGQRLQLLDLSVNLLEYIANDSFVALRELRTLRLGGNILTELDYGA 248

  Fly   338 FAALLNLDTLDLSYNNLEFLEE-QIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGH 401
            |..|..|..||:..|||..:.. |:   :.|..:..|:|:||..:.|..:||.:|..|:.|.|..
Mosquito   249 FHGLSGLKALDIVDNNLTVVPTLQL---SKLCNLTYLSLSGNYFESLPAVAFLNLFQLQQLHLDR 310

  Fly   402 -NELKSLDVRMFAPMRRLQKLHLGHN-LLEEINLDVLESLSSVQEILVDNNRLTFLAKVNVSFPN 464
             :.|:.:|.|.|.....|:.|.|..| ....:.|.:..|..::.||.:..|.|..|..|:.....
Mosquito   311 LDRLQRIDARAFVDNAALRILTLDDNPSFASLPLRLFHSNPNLAEISMRRNALIRLDAVHFPLDR 375

  Fly   465 LKRVAIEGNPWQCPCFVKLQHWL 487
            |.|:.:.|||..|.|.:.   ||
Mosquito   376 LHRLELGGNPLVCNCSLL---WL 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	37/107 (35%)
		LRR_8	104..164	CDD:290566	3/7 (43%)
		leucine-rich repeat	106..129	CDD:275380
		leucine-rich repeat	130..153	CDD:275380
		leucine-rich repeat	154..195	CDD:275380	12/46 (26%)
		LRR_RI	194..455	CDD:238064	86/268 (32%)
		LRR_8	194..254	CDD:290566	23/59 (39%)
		leucine-rich repeat	196..219	CDD:275380	10/22 (45%)
		leucine-rich repeat	220..243	CDD:275380	9/22 (41%)
		leucine-rich repeat	244..267	CDD:275380	8/22 (36%)
		LRR_8	271..330	CDD:290566	23/63 (37%)
		leucine-rich repeat	272..295	CDD:275380	7/27 (26%)
		leucine-rich repeat	296..319	CDD:275380	9/22 (41%)
		LRR_8	319..380	CDD:290566	20/61 (33%)
		leucine-rich repeat	320..343	CDD:275380	8/22 (36%)
		leucine-rich repeat	344..369	CDD:275380	8/25 (32%)
		LRR_8	368..428	CDD:290566	19/61 (31%)
		leucine-rich repeat	370..393	CDD:275380	8/22 (36%)
		leucine-rich repeat	394..417	CDD:275380	7/23 (30%)
		leucine-rich repeat	418..441	CDD:275380	6/23 (26%)
AgaP_AGAP011229	XP_309414.4	leucine-rich repeat	62..84	CDD:275380	5/22 (23%)
		leucine-rich repeat	85..108	CDD:275380	7/22 (32%)
		LRR_RI	<108..289	CDD:238064	65/190 (34%)
		LRR_8	109..167	CDD:290566	23/57 (40%)
		leucine-rich repeat	109..132	CDD:275380	10/22 (45%)
		leucine-rich repeat	133..156	CDD:275380	9/22 (41%)
		LRR_8	155..239	CDD:290566	30/90 (33%)
		leucine-rich repeat	157..180	CDD:275380	10/29 (34%)
		leucine-rich repeat	181..206	CDD:275380	6/24 (25%)
		leucine-rich repeat	207..230	CDD:275380	9/22 (41%)
		LRR_8	229..289	CDD:290566	20/62 (32%)
		leucine-rich repeat	231..254	CDD:275380	8/22 (36%)
		leucine-rich repeat	255..278	CDD:275380	8/25 (32%)
		LRR_8	278..337	CDD:290566	18/58 (31%)
		leucine-rich repeat	279..302	CDD:275380	8/22 (36%)
		leucine-rich repeat	303..324	CDD:275380	7/20 (35%)
		leucine-rich repeat	353..366	CDD:275378	4/12 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910