DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and AgaP_AGAP011292

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_309356.4	Gene:	AgaP_AGAP011292 / 1270641	VectorBaseID:	AGAP011292	Length:	1292	Species:	Anopheles gambiae

Alignment Length:	664	Identity:	152/664 - (22%)
Similarity:	239/664 - (35%)	Gaps:	220/664 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PILHGADLCQPIGWRNFQCSEVASLQDLVDLGAENWHTLAIRNVQT-ELEVGSGENADHLA---N 81
            |.:.|.|      :.|...||....:::..:....|..|....:.| ..|:|.....:||:   |
Mosquito     8 PFVRGID------FTNNDFSEDKFPKNIKHMSGVQWLKLDRTGMDTIPDEMGKLVKLEHLSMKNN 66

  Fly    82 LLD------LDLTGAAPINVHTNGFSI---------LPNLRQLNLSGCGLVDIRGNHFAPE---- 127
            .|:      .:|.....:||..|....         |..|..|:||...|.::      ||
Mosquito    67 QLEKLFGQLSELGCLRSLNVRRNKLKSHAIPSDLFELEELTTLDLSHNRLKEV------PEGLEK 125

  Fly   128 -SALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNALKQCDLPHMPLLNRLELGHNRLVNATFG 191
             .||..::.|:||:|.:....|.||..|::.:.|:|.|:  .||  |...||.
Mosquito   126 AKALLVLNLSNNQIETIPPSLFINLTDLLFLDLSNNKLE--TLP--PQTRRLS------------ 174

  Fly   192 VCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETF----QPLAQLRKLNLSQN 252
               .||.||||||.|....:.....|..|:.||:...:.:   :..|    ..|:.|::|:||||
Mosquito   175 ---NLQTLILNDNPLELFQLRQLPSLQSLVCLQMRNTQRT---INNFPASLDSLSNLQELDLSQN 233

  Fly   253 ALDALRPNVFGAVQNFVLHLQQLDLSGN---RIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHF 314
            ||.    .|.||:.| :.:|::|:|:.|   .:..|.:|    |.:|:.|::|||.:.:| ||..
Mosquito   234 ALS----KVPGALYN-LANLKRLNLNDNVLEELSPLIEN----LTKLETLNLSRNKLTAL-PATL 288

  Fly   315 VGLGSLRKLYLQYNAI-LEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGN 378
            ..|..||:||:..|.: .|..|::...|..|:....|.|.||.:.|.:..|  ...:::|||:.|
Mosquito   289 CKLQELRRLYVNDNLLNFEGIPSSIGKLSALEVFSASNNELEMVPEGLCRG--CGSLKKLNLSSN 351

  Fly   379 RMKHLHPLAFSSLPFLEYLKLGHN-----------------------------ELKSLDVRMFA- 413
            ::..| |.|...|..:|.|.|.:|                             :|:.....:.|
Mosquito   352 KLITL-PEAIHLLTDMEQLDLRNNPDLVMPPKPIEAQRGDGLAYYNIDFSLQTQLRLAGANVPAQ 415

  Fly   414 ----------PMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVD-NNRLTF------------- 454
                      |:.|..:|..|.......|.|..:.|..:|:|..| |:.|.|
Mosquito   416 VQGAANAGKDPIARKLRLRRGARNDSSDNQDSAKILKGMQDIAKDKNSGLGFGEEKVENLKPKRW 480

  Fly   455 ---LAKVNVSF-----------------------PNLKRVAIEGNPWQCPCFV--KLQH------ 485
               |.|..|.:                       ||....|..|..::..|::  |..|
Mosquito   481 DETLEKPPVDYSEIFEDEDGQYPGLTVWEIENFLPNKIEEAAHGKFYEGDCYIVLKTSHDDSGQL 545

  Fly   486 ------WLATR--------------------------------------------DVVYL---RD 497
                  |:.|:                                            ||.|:   |.
Mosquito   546 SWEIYFWIGTKATLDKRACSAIHAVNLRNYLGARCRTIREEQGDESDEFLALFDSDVTYIEGGRT 610

  Fly   498 NTGYYKGERPLCIV 511
            :||:|..|..:.||
Mosquito   611 STGFYTIENAVYIV 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	49/161 (30%)
		LRR_8	104..164	CDD:290566	19/64 (30%)
		leucine-rich repeat	106..129	CDD:275380	7/27 (26%)
		leucine-rich repeat	130..153	CDD:275380	8/22 (36%)
		leucine-rich repeat	154..195	CDD:275380	9/40 (23%)
		LRR_RI	194..455	CDD:238064	85/325 (26%)
		LRR_8	194..254	CDD:290566	21/63 (33%)
		leucine-rich repeat	196..219	CDD:275380	10/22 (45%)
		leucine-rich repeat	220..243	CDD:275380	5/26 (19%)
		leucine-rich repeat	244..267	CDD:275380	11/22 (50%)
		LRR_8	271..330	CDD:290566	21/61 (34%)
		leucine-rich repeat	272..295	CDD:275380	7/25 (28%)
		leucine-rich repeat	296..319	CDD:275380	9/22 (41%)
		LRR_8	319..380	CDD:290566	19/61 (31%)
		leucine-rich repeat	320..343	CDD:275380	8/23 (35%)
		leucine-rich repeat	344..369	CDD:275380	7/24 (29%)
		LRR_8	368..428	CDD:290566	18/99 (18%)
		leucine-rich repeat	370..393	CDD:275380	8/22 (36%)
		leucine-rich repeat	394..417	CDD:275380	7/62 (11%)
		leucine-rich repeat	418..441	CDD:275380	5/22 (23%)
AgaP_AGAP011292	XP_309356.4	LRR_8	33..91	CDD:290566	13/57 (23%)
		leucine-rich repeat	35..57	CDD:275380	5/21 (24%)
		leucine-rich repeat	58..80	CDD:275380	5/21 (24%)
		leucine-rich repeat	81..105	CDD:275380	4/23 (17%)
		LRR_RI	100..353	CDD:238064	88/292 (30%)
		LRR_8	105..163	CDD:290566	19/63 (30%)
		leucine-rich repeat	106..128	CDD:275380	7/27 (26%)
		leucine-rich repeat	129..152	CDD:275380	8/22 (36%)
		leucine-rich repeat	153..175	CDD:275380	9/40 (23%)
		LRR_8	156..235	CDD:290566	29/100 (29%)
		leucine-rich repeat	176..224	CDD:275380	15/50 (30%)
		LRR_8	223..281	CDD:290566	24/66 (36%)
		leucine-rich repeat	225..247	CDD:275380	12/26 (46%)
		leucine-rich repeat	248..270	CDD:275380	7/25 (28%)
		LRR_8	269..353	CDD:290566	28/86 (33%)
		leucine-rich repeat	271..293	CDD:275380	9/22 (41%)
		leucine-rich repeat	294..318	CDD:275380	8/23 (35%)
		leucine-rich repeat	319..342	CDD:275380	7/24 (29%)
		gelsolin_S1_like	497..608	CDD:200446	12/110 (11%)
		gelsolin_like	625..712	CDD:200436	152/664 (23%)
		gelsolin_S3_like	742..840	CDD:200448
		gelsolin_like	971..1050	CDD:200436
		gelsolin_S5_like	1073..1176	CDD:200444
		gelsolin_S6_like	1187..1285	CDD:200447
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910