DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and AgaP_AGAP007030

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_308742.4	Gene:	AgaP_AGAP007030 / 1270075	VectorBaseID:	AGAP007030	Length:	1017	Species:	Anopheles gambiae

Alignment Length:	486	Identity:	119/486 - (24%)
Similarity:	190/486 - (39%)	Gaps:	146/486 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 ALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNALKQCDLPHMPLLNRLELGHNRLVNATFGVC 193
            ||:.:..:.:.:|.::...|..|.:|...|...|.:.   ..|:|..:..:....||
Mosquito   144 ALETVAITKSPIETVNLWLFSKLTRLYELNLCSNKIL---FLHLPATSAGDFASLRL-------- 197

  Fly   194 PQLQELILNDNQLIQLDVNAFRGL----------------------HGLLELQLSGNRLSSIGLE 236
                 |.|.||.|..:::.||.|:                      :.|..|:||||||.::...
Mosquito   198 -----LFLADNLLTTINLGAFNGMQALQTLDFQNNRIRRVQGALVSNSLQTLELSGNRLETLYCC 257

  Fly   237 TFQPLAQLRKLNLSQNALDAL-------RPNVF------------GAVQN-FVL-HLQQLDLSGN 280
            .:. |..|..|.||.|.|..|       .|||.            |...| |.| .|||||:|.|
Mosquito   258 EWH-LPNLNHLALSLNVLSMLPTCLSLTMPNVLYLILDRNALIDSGTWYNIFTLKRLQQLDISHN 321

  Fly   281 RI-RLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGL--------GSLRKLYLQYNAI------ 330
            |: :.:.||   :...|..||:..|:|..|...:.:.:        .:||...|:.||.
Mosquito   322 RLTKAVLDN---ISNSLLFLDLQYNNITVLHRRNILQMHTTITVIGSTLRGFVLEDNATYNMVCL 383

  Fly   331 --LEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGN-----------------------TLPRM 370
              .::...:|....||:||.:.::|||.|.:.|  ||                       .|.|:
Mosquito   384 EKTQLNHISFGTRCNLETLKIQHSNLEQLPQSI--GNLKALESLTLSHSLIQAIDLNLVAELSRL 446

  Fly   371 RRLNLNGNRMKHL---------HPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHN 426
            ..|:|:.||:..|         ||     .|.|..|.||.|:|||:::.:|.||..|..|.|.||
Mosquito   447 VLLDLSKNRLHSLYDSCARTTTHP-----YPSLSELYLGENKLKSINMDVFQPMVSLTWLDLSHN 506

  Fly   427 LL----------EEINLDVLESLSSVQE-------------ILVDNNRLTFLAK-VNVSFPNLKR 467
            .:          ..|:||:  |.:.:.|             :::::|||..|.: :..:|.|:..
Mosquito   507 HITVVSGSLVATSLISLDL--SFNRLVEMDCCGWVIPKLYGMIINDNRLPALPRCLEHAFQNVTH 569

  Fly   468 VAIEGNPWQCPCFVKLQHWLATRDVVYLRDN 498
            :..:.|..|.....:|.. |...:::.:.||
Mosquito   570 LTFDTNQLQPDIMFQLGR-LTNIELLSITDN 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	35/148 (24%)
		LRR_8	104..164	CDD:290566	8/34 (24%)
		leucine-rich repeat	106..129	CDD:275380	119/486 (24%)
		leucine-rich repeat	130..153	CDD:275380	4/22 (18%)
		leucine-rich repeat	154..195	CDD:275380	7/40 (18%)
		LRR_RI	194..455	CDD:238064	98/375 (26%)
		LRR_8	194..254	CDD:290566	22/81 (27%)
		leucine-rich repeat	196..219	CDD:275380	8/44 (18%)
		leucine-rich repeat	220..243	CDD:275380	9/22 (41%)
		leucine-rich repeat	244..267	CDD:275380	11/41 (27%)
		LRR_8	271..330	CDD:290566	20/67 (30%)
		leucine-rich repeat	272..295	CDD:275380	10/23 (43%)
		leucine-rich repeat	296..319	CDD:275380	6/30 (20%)
		LRR_8	319..380	CDD:290566	22/91 (24%)
		leucine-rich repeat	320..343	CDD:275380	6/30 (20%)
		leucine-rich repeat	344..369	CDD:275380	11/47 (23%)
		LRR_8	368..428	CDD:290566	25/68 (37%)
		leucine-rich repeat	370..393	CDD:275380	7/31 (23%)
		leucine-rich repeat	394..417	CDD:275380	11/22 (50%)
		leucine-rich repeat	418..441	CDD:275380	9/32 (28%)
AgaP_AGAP007030	XP_308742.4	leucine-rich repeat	122..144	CDD:275380	119/486 (24%)
		leucine-rich repeat	145..168	CDD:275380	4/22 (18%)
		LRR_8	167..229	CDD:290566	15/77 (19%)
		leucine-rich repeat	169..194	CDD:275380	5/27 (19%)
		leucine-rich repeat	195..218	CDD:275380	10/35 (29%)
		leucine-rich repeat	219..240	CDD:275380	0/20 (0%)
		leucine-rich repeat	241..263	CDD:275380	9/22 (41%)
		LRR_RI	262..535	CDD:238064	78/284 (27%)
		leucine-rich repeat	264..287	CDD:275380	7/22 (32%)
		leucine-rich repeat	288..312	CDD:275380	5/23 (22%)
		leucine-rich repeat	313..334	CDD:275380	10/23 (43%)
		LRR_8	398..456	CDD:290566	16/59 (27%)
		leucine-rich repeat	399..421	CDD:275380	10/23 (43%)
		leucine-rich repeat	422..445	CDD:275380	1/22 (5%)
		LRR_8	444..508	CDD:290566	25/68 (37%)
		leucine-rich repeat	446..473	CDD:275380	7/31 (23%)
		leucine-rich repeat	474..497	CDD:275380	11/22 (50%)
		leucine-rich repeat	498..519	CDD:275380	5/20 (25%)
		leucine-rich repeat	520..566	CDD:275380	10/47 (21%)
		leucine-rich repeat	567..590	CDD:275380	4/23 (17%)
		leucine-rich repeat	591..614	CDD:275380	2/9 (22%)
		leucine-rich repeat	747..770	CDD:275380
		leucine-rich repeat	771..796	CDD:275380
		leucine-rich repeat	797..820	CDD:275380
		LRR_8	800..>837	CDD:290566
		leucine-rich repeat	821..836	CDD:275380
		leucine-rich repeat	844..865	CDD:275380
		leucine-rich repeat	866..889	CDD:275380
		leucine-rich repeat	890..915	CDD:275380
		leucine-rich repeat	916..938	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910