DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and LRIG3

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_700356.2	Gene:	LRIG3 / 121227	HGNCID:	30991	Length:	1119	Species:	Homo sapiens

Alignment Length:	429	Identity:	122/429 - (28%)
Similarity:	199/429 - (46%)	Gaps:	46/429 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 HLANLLDLDLTGAAPINVHTNGFSILPNL-------RQLNLSGCGLVDIRGNHFAPESALQRIDF 135
            ||.:|.:        :.::.|....:|||       ..|:|:|..:|:|...|.....:|:.:|.
Human    96 HLQSLRE--------VKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDL 152

  Fly   136 SHNQMELLDRDFFGNLRKLIYANFSHNALKQCDLPHMPLLNR----LELGHNRL--VNATFGVCP 194
            |.|.:..|...|.....|.:|.|  .|.:...:..:...|..    |:|..||:  :.......|
Human   153 SSNNISELQTAFPALQLKYLYLN--SNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLP 215

  Fly   195 QLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRP 259
            |||.|.||.|::..:|...|:||..|..|::..|.::.:....|..|:.:..|.|..|.|..:..
Human   216 QLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITK 280

  Fly   260 N-VFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKL 323
            . ::|     :|.||:|.||.|.|..:..:.:....:|..||::.|.::.|..:.|:||..|..|
Human   281 GWLYG-----LLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTL 340

  Fly   324 YLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGG-NTLPRMRRLNLNGNRMKHLHPLA 387
            ::..|.:..|....|..|.:|.||||..|.:.:..|.:.|. :.|.::|||.|.|||::.:...|
Human   341 HIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKA 405

  Fly   388 FSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLG-HNLLEEINLDVLESLSSVQEILVDNNR 451
            |:.|..||:|.|..|.:.||....|:.|::||:|||. .:||.:..|..|      .:.:.:||
Human   406 FTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWL------PQWVAENN- 463

  Fly   452 LTFLAKVNVS--FPNLKR----VAIEGNPWQCPCFVKLQ 484
              |.:.||.|  .|.|.:    .|:..:.:.|..|.|.|
Human   464 --FQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQ 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	45/165 (27%)
		LRR_8	104..164	CDD:290566	19/66 (29%)
		leucine-rich repeat	106..129	CDD:275380	7/29 (24%)
		leucine-rich repeat	130..153	CDD:275380	6/22 (27%)
		leucine-rich repeat	154..195	CDD:275380	8/46 (17%)
		LRR_RI	194..455	CDD:238064	83/263 (32%)
		LRR_8	194..254	CDD:290566	20/59 (34%)
		leucine-rich repeat	196..219	CDD:275380	10/22 (45%)
		leucine-rich repeat	220..243	CDD:275380	5/22 (23%)
		leucine-rich repeat	244..267	CDD:275380	5/23 (22%)
		LRR_8	271..330	CDD:290566	18/58 (31%)
		leucine-rich repeat	272..295	CDD:275380	7/22 (32%)
		leucine-rich repeat	296..319	CDD:275380	8/22 (36%)
		LRR_8	319..380	CDD:290566	21/61 (34%)
		leucine-rich repeat	320..343	CDD:275380	6/22 (27%)
		leucine-rich repeat	344..369	CDD:275380	9/25 (36%)
		LRR_8	368..428	CDD:290566	24/60 (40%)
		leucine-rich repeat	370..393	CDD:275380	10/22 (45%)
		leucine-rich repeat	394..417	CDD:275380	9/22 (41%)
		leucine-rich repeat	418..441	CDD:275380	9/23 (39%)
LRIG3	NP_700356.2	LRR	20..395	CDD:227223	85/313 (27%)
		leucine-rich repeat	58..74	CDD:275378
		LRR_RI	<65..>245	CDD:238064	41/158 (26%)
		LRR 1	75..96		122/429 (28%)
		leucine-rich repeat	78..99	CDD:275378	2/2 (100%)
		LRR 2	99..120		5/28 (18%)
		leucine-rich repeat	100..115	CDD:275378	2/22 (9%)
		LRR 3	122..142		6/19 (32%)
		leucine-rich repeat	123..146	CDD:275378	6/22 (27%)
		LRR 4	146..167		6/20 (30%)
		leucine-rich repeat	147..168	CDD:275380	6/20 (30%)
		LRR 5	168..189		4/22 (18%)
		leucine-rich repeat	169..192	CDD:275380	5/24 (21%)
		LRR 6	193..214		4/20 (20%)
		leucine-rich repeat	194..216	CDD:275380	4/21 (19%)
		LRR 7	216..237		9/20 (45%)
		leucine-rich repeat	217..240	CDD:275380	10/22 (45%)
		LRR 8	240..261		4/20 (20%)
		leucine-rich repeat	241..264	CDD:275380	5/22 (23%)
		LRR_RI	262..>446	CDD:238064	61/188 (32%)
		LRR 9	264..285		4/20 (20%)
		leucine-rich repeat	265..288	CDD:275380	5/27 (19%)
		LRR 10	288..309		7/20 (35%)
		leucine-rich repeat	289..312	CDD:275380	7/22 (32%)
		LRR 11	312..333		6/20 (30%)
		leucine-rich repeat	313..336	CDD:275380	8/22 (36%)
		LRR 12	336..357		5/20 (25%)
		leucine-rich repeat	337..360	CDD:275380	6/22 (27%)
		LRR 13	360..382		8/21 (38%)
		leucine-rich repeat	361..385	CDD:275380	8/23 (35%)
		LRR_8	387..442	CDD:290566	23/54 (43%)
		LRR 14	387..408		9/20 (45%)
		leucine-rich repeat	388..411	CDD:275380	10/22 (45%)
		LRR 15	411..432		8/20 (40%)
		leucine-rich repeat	412..435	CDD:275380	9/22 (41%)
		LRRCT	446..494	CDD:214507	13/56 (23%)
		Ig_3	498..585	CDD:290638	2/3 (67%)
		I-set	499..599	CDD:254352	1/2 (50%)
		I-set	603..693	CDD:254352
		Ig_1	620..694	CDD:143240
		I-set	697..784	CDD:254352
		IGc2	711..774	CDD:197706
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1073..1093
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910