DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and LRRK2

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_940980.4	Gene:	LRRK2 / 120892	HGNCID:	18618	Length:	2527	Species:	Homo sapiens

Alignment Length:	380	Identity:	103/380 - (27%)
Similarity:	158/380 - (41%)	Gaps:	102/380 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 IDFSHNQMELLDRDFFGNLRKLIYANFSHNALKQ--CDLPHMPLLNRLELGHNRLVNATFGVCPQ 195
            :|.|.|::..:|                  ||.|  |...|:..|.:|||..|.|.:....:|..
Human   987 LDLSANELRDID------------------ALSQKCCISVHLEHLEKLELHQNALTSFPQQLCET 1033

  Fly   196 LQELILNDNQLIQLDVNAFRGLHGLL-------ELQLSGNRLS-SIGLETFQPLAQLRKLNLSQN 252
            |:.|...|     |..|.|......|       .|.:|.|.:. |:.|:.......|::.|||.|
Human  1034 LKSLTHLD-----LHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 1093

  Fly   253 ALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGL 317
            .|..:..|:...|:.    |:||.|.||:|..:. :..| |..|::|::|:|.|:|||
Human  1094 QLSFVPENLTDVVEK----LEQLILEGNKISGIC-SPLR-LKELKILNLSKNHISSLS------- 1145

  Fly   318 GSLRKLYLQYNAILEIKP--ATFAALLN-----------LDTLDLSYNNLEFLEEQIFGGNTLPR 369
                      ...||..|  .:|:|.:|           :..|.||.|....:.|.|.   .||.
Human  1146 ----------ENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAIL---NLPH 1197

  Fly   370 MRRLNLNGNRMKHL-HPLAFSSLPFLEYLKLGHNELKSLDVRMFAPM-RRLQKLHLGHNLLEEI- 431
            :|.|:::.|.:::| .|..:.||...|.| ..||::..||:...|.: .|::||||.||.|:||
Human  1198 LRSLDMSSNDIQYLPGPAHWKSLNLRELL-FSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIP 1261

  Fly   432 -NLDVLESLSSVQEILVDNNRLTFLAKVNV---SFPN----LKRVAIEGNPWQCP 478
             .:..||:|:|:.            ...|:   ||||    |.::      |..|
Human  1262 PEIGCLENLTSLD------------VSYNLELRSFPNEMGKLSKI------WDLP 1298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	34/132 (26%)
		LRR_8	104..164	CDD:290566	4/30 (13%)
		leucine-rich repeat	106..129	CDD:275380
		leucine-rich repeat	130..153	CDD:275380	4/19 (21%)
		leucine-rich repeat	154..195	CDD:275380	12/42 (29%)
		LRR_RI	194..455	CDD:238064	79/285 (28%)
		LRR_8	194..254	CDD:290566	17/67 (25%)
		leucine-rich repeat	196..219	CDD:275380	6/22 (27%)
		leucine-rich repeat	220..243	CDD:275380	6/30 (20%)
		leucine-rich repeat	244..267	CDD:275380	8/22 (36%)
		LRR_8	271..330	CDD:290566	17/58 (29%)
		leucine-rich repeat	272..295	CDD:275380	9/22 (41%)
		leucine-rich repeat	296..319	CDD:275380	8/22 (36%)
		LRR_8	319..380	CDD:290566	17/73 (23%)
		leucine-rich repeat	320..343	CDD:275380	5/24 (21%)
		leucine-rich repeat	344..369	CDD:275380	7/24 (29%)
		LRR_8	368..428	CDD:290566	22/61 (36%)
		leucine-rich repeat	370..393	CDD:275380	7/23 (30%)
		leucine-rich repeat	394..417	CDD:275380	7/23 (30%)
		leucine-rich repeat	418..441	CDD:275380	12/24 (50%)
LRRK2	NP_940980.4	Required for RAB29-mediated activation. /evidence=ECO:0000269\|PubMed:29212815	1..969
		LRR 1	983..1004		7/34 (21%)
		leucine-rich repeat	985..1012	CDD:275380	9/42 (21%)
		LRR	1012..>1286	CDD:227223	89/317 (28%)
		LRR 2	1012..1033		7/20 (35%)
		leucine-rich repeat	1013..1036	CDD:275380	8/22 (36%)
		LRR 3	1036..1057		6/25 (24%)
		leucine-rich repeat	1037..1084	CDD:275380	11/51 (22%)
		LRR 4	1059..1080		5/20 (25%)
		LRR 5	1084..1105		7/20 (35%)
		leucine-rich repeat	1085..1108	CDD:275380	8/22 (36%)
		LRR 6	1108..1129		8/26 (31%)
		leucine-rich repeat	1109..1130	CDD:275380	9/22 (41%)
		LRR 7	1130..1150		8/36 (22%)
		leucine-rich repeat	1131..1174	CDD:275380	14/59 (24%)
		LRR 8	1174..1196		6/24 (25%)
		leucine-rich repeat	1175..1197	CDD:275380	7/24 (29%)
		LRR 9	1197..1218		5/20 (25%)
		leucine-rich repeat	1198..1221	CDD:275380	6/22 (27%)
		LRR 10	1221..1241		6/20 (30%)
		leucine-rich repeat	1222..1246	CDD:275380	7/24 (29%)
		LRR 11	1246..1267		10/20 (50%)
		leucine-rich repeat	1247..1269	CDD:275380	10/21 (48%)
		LRR 12	1269..1291		7/33 (21%)
		RocCOR	1334..1507	CDD:206741
		COR	1527..1740	CDD:318343
		STKc_LRRK2	1884..2135	CDD:270970
		WD 1	2139..2183
		WD 2	2188..2228
		WD 3	2233..2276
		WD 4	2281..2327
		WD 5	2333..2377
		WD 6	2402..2438
		WD 7	2443..2497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910