DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6749 and Lrrtm2

DIOPT Version :9

Sequence 1:NP_648354.1 Gene:CG6749 / 39144 FlyBaseID:FBgn0036040 Length:552 Species:Drosophila melanogaster
Sequence 2:NP_821072.1 Gene:Lrrtm2 / 107065 MGIID:2389174 Length:515 Species:Mus musculus


Alignment Length:285 Identity:91/285 - (31%)
Similarity:146/285 - (51%) Gaps:16/285 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly   215 RGLH--------GLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLH 271
            :|.|        |.|.|.|..|.::::..:.|...:||..|:|..|.:..::.:.|..:..    
Mouse    50 QGFHSVPNATDKGSLGLSLRHNHITALERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYK---- 110

  Fly   272 LQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPA 336
            |::|.||.|:|..|.:..|..|..||.||:|.|.::||.|..|.||..|:.|:|:.|::..|...
Mouse   111 LKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVR 175

  Fly   337 TFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGH 401
            .|....:|:.||||.|.|..|....|.|  |.::|.|:|..|::..::...|..|..|..|.|..
Mouse   176 LFWDCRSLEFLDLSTNRLRSLARNGFAG--LIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQW 238

  Fly   402 NELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFL-AKVNVSFPNL 465
            |::.:|...|......|:||.|..|.::.|:|.|.|::.:::.:|:|||:|..| :|:..|..:|
Mouse   239 NKISNLTCGMDWTWSTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLKSL 303

  Fly   466 KRVAIEGNPWQC-PCFVKLQHWLAT 489
            ..|.:.||.|:| |....|..||.:
Mouse   304 TTVGLSGNLWECSPRVCALASWLGS 328

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6749NP_648354.1 LRR_RI 103..>256 CDD:238064 13/48 (27%)
LRR_8 104..164 CDD:290566
leucine-rich repeat 106..129 CDD:275380
leucine-rich repeat 130..153 CDD:275380
leucine-rich repeat 154..195 CDD:275380
LRR_RI 194..455 CDD:238064 78/247 (32%)
LRR_8 194..254 CDD:290566 13/46 (28%)
leucine-rich repeat 196..219 CDD:275380 2/11 (18%)
leucine-rich repeat 220..243 CDD:275380 5/22 (23%)
leucine-rich repeat 244..267 CDD:275380 5/22 (23%)
LRR_8 271..330 CDD:290566 25/58 (43%)
leucine-rich repeat 272..295 CDD:275380 9/22 (41%)
leucine-rich repeat 296..319 CDD:275380 12/22 (55%)
LRR_8 319..380 CDD:290566 21/60 (35%)
leucine-rich repeat 320..343 CDD:275380 6/22 (27%)
leucine-rich repeat 344..369 CDD:275380 11/24 (46%)
LRR_8 368..428 CDD:290566 17/59 (29%)
leucine-rich repeat 370..393 CDD:275380 6/22 (27%)
leucine-rich repeat 394..417 CDD:275380 6/22 (27%)
leucine-rich repeat 418..441 CDD:275380 9/22 (41%)
Lrrtm2NP_821072.1 LRR 1 63..83 5/19 (26%)
LRR <65..312 CDD:227223 80/252 (32%)
leucine-rich repeat 66..86 CDD:275380 4/19 (21%)
LRR 2 86..107 6/20 (30%)
leucine-rich repeat 87..110 CDD:275380 5/22 (23%)
LRR 3 110..131 8/24 (33%)
leucine-rich repeat 111..134 CDD:275380 9/22 (41%)
LRR 4 134..155 10/20 (50%)
leucine-rich repeat 135..158 CDD:275380 12/22 (55%)
LRR 5 158..179 6/20 (30%)
leucine-rich repeat 159..182 CDD:275380 6/22 (27%)
LRR 6 182..203 9/20 (45%)
leucine-rich repeat 183..206 CDD:275380 11/24 (46%)
LRR 7 206..227 5/20 (25%)
leucine-rich repeat 207..230 CDD:275380 6/22 (27%)
LRR 8 230..251 6/20 (30%)
leucine-rich repeat 231..254 CDD:275380 6/22 (27%)
LRR 9 254..275 8/20 (40%)
leucine-rich repeat 255..278 CDD:275380 9/22 (41%)
LRR 10 278..299 7/20 (35%)
leucine-rich repeat 279..300 CDD:275380 7/20 (35%)
PCC 284..>351 CDD:188093 17/45 (38%)
Involved in DLG4-binding. /evidence=ECO:0000250 512..515
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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