DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and Scrib

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_598850.1	Gene:	Scrib / 105782	MGIID:	2145950	Length:	1665	Species:	Mus musculus

Alignment Length:	328	Identity:	97/328 - (29%)
Similarity:	150/328 - (45%)	Gaps:	45/328 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 LQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPN 260
            |:||:|:.|||.:|....|| |..|.:|.||.|.:..:..|... ..||.:|::|:|.:..:..:
Mouse    38 LEELLLDANQLRELPKPFFR-LLNLRKLGLSDNEIQRLPPEVAN-FMQLVELDVSRNDIPEIPES 100

  Fly   261 VFGAVQNFVLHLQQLDLSGNRIRLLFD--NQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKL 323
            :     .|...|:..|.|||.:..|.|  .|.|.||.|.:.|||..::    |.....|.:|..|
Mouse   101 I-----KFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQAL----PGDVGNLANLVTL 156

  Fly   324 YLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAF 388
            .|:.| :|:..||:.:.|:.|:.|||..|:||.|.:.:   ..||.:|.|.|:.|::..|.| ..
Mouse   157 ELREN-LLKSLPASLSFLVKLEQLDLGGNDLEVLPDTL---GALPNLRELWLDRNQLSALPP-EL 216

  Fly   389 SSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEI--NLDVLESLSSVQEILVDNNR 451
            .:|..|..|.:..|.|:.|.|.: ..:..|..|.|..|||:.:  .:..|:.||.::   ||.||
Mouse   217 GNLRRLVCLDVSENRLEELPVEL-GGLALLTDLLLSQNLLQRLPEGIGQLKQLSILK---VDQNR 277

  Fly   452 LTFLAKVNVSFPNLKRVAIEGN-----PWQCPCFVKLQHWLATRD----------------VVYL 495
            |..:.:......||..:.:..|     |.......||.:....|:                |:.|
Mouse   278 LCEVTEAIGDCENLSELILTENLLTALPHSLGKLTKLTNLNVDRNHLEVLPPEIGGCVALSVLSL 342

  Fly   496 RDN 498
            |||
Mouse   343 RDN 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	22/59 (37%)
		LRR_8	104..164	CDD:290566
		leucine-rich repeat	106..129	CDD:275380
		leucine-rich repeat	130..153	CDD:275380
		leucine-rich repeat	154..195	CDD:275380
		LRR_RI	194..455	CDD:238064	85/262 (32%)
		LRR_8	194..254	CDD:290566	22/57 (39%)
		leucine-rich repeat	196..219	CDD:275380	11/22 (50%)
		leucine-rich repeat	220..243	CDD:275380	6/22 (27%)
		leucine-rich repeat	244..267	CDD:275380	4/22 (18%)
		LRR_8	271..330	CDD:290566	21/60 (35%)
		leucine-rich repeat	272..295	CDD:275380	10/24 (42%)
		leucine-rich repeat	296..319	CDD:275380	6/22 (27%)
		LRR_8	319..380	CDD:290566	22/60 (37%)
		leucine-rich repeat	320..343	CDD:275380	8/22 (36%)
		leucine-rich repeat	344..369	CDD:275380	9/24 (38%)
		LRR_8	368..428	CDD:290566	18/59 (31%)
		leucine-rich repeat	370..393	CDD:275380	7/22 (32%)
		leucine-rich repeat	394..417	CDD:275380	6/22 (27%)
		leucine-rich repeat	418..441	CDD:275380	8/24 (33%)
Scrib	NP_598850.1	LRR_RI	12..232	CDD:238064	68/209 (33%)
		leucine-rich repeat	14..37	CDD:275380
		leucine-rich repeat	38..60	CDD:275380	11/22 (50%)
		LRR	39..405	CDD:227223	96/327 (29%)
		leucine-rich repeat	61..83	CDD:275380	6/22 (27%)
		leucine-rich repeat	84..106	CDD:275380	5/26 (19%)
		leucine-rich repeat	107..129	CDD:275380	8/21 (38%)
		leucine-rich repeat	130..152	CDD:275380	8/25 (32%)
		leucine-rich repeat	153..175	CDD:275380	8/22 (36%)
		leucine-rich repeat	176..198	CDD:275380	9/24 (38%)
		leucine-rich repeat	199..221	CDD:275380	7/22 (32%)
		leucine-rich repeat	268..290	CDD:275380	7/24 (29%)
		LRR_4	289..329	CDD:289563	7/39 (18%)
		leucine-rich repeat	291..313	CDD:275380	3/21 (14%)
		leucine-rich repeat	314..336	CDD:275380	2/21 (10%)
		leucine-rich repeat	360..381	CDD:275380
		PDZ	711..799	CDD:214570
		PDZ_signaling	854..933	CDD:238492
		PDZ_signaling	988..1076	CDD:238492
		PDZ_signaling	1085..1175	CDD:238492
		AbLIM_anchor	1565..>1659	CDD:292800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910