DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and LRRN2

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_006329.2	Gene:	LRRN2 / 10446	HGNCID:	16914	Length:	713	Species:	Homo sapiens

Alignment Length:	491	Identity:	130/491 - (26%)
Similarity:	192/491 - (39%)	Gaps:	117/491 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VLPLLL-WLLCMGFPILHGADLCQPIGWRNFQCSEVASLQDLVDLGAENWHT--LAIRNVQTELE 69
            |.|||| |:.        ||....|:...:..|....:.|      ...|:|  .:.|...|
Human     5 VAPLLLAWVA--------GATAAVPVVPWHVPCPPQCACQ------IRPWYTPRSSYREATT--- 52

  Fly    70 VGSGENADHLANLLDLDLTGAAPINVHTNGFSILPNLRQLNLSGCGLVDIRGNHFAPESALQRID 134
                      .:..||.||...|         .||       :|...:.::.|      ::.|:|
Human    53 ----------VDCNDLFLTAVPP---------ALP-------AGTQTLLLQSN------SIVRVD 85

  Fly   135 FSHNQMELLDRDFFGNLRKLIYANFSHNALKQCDLPHMPLLNRLELGHN---RLVNATFGVCPQL 196
                |.||   .:..||.:|..:..|.:..:.||...:|.|..|.|..|   ||.:.:|.....|
Human    86 ----QSEL---GYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASL 143

  Fly   197 QELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNV 261
            |||.||.|||.::...||.||..||.|.|:.|.|.:|....|:.|..|..|.:..|.:||:....
Human   144 QELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208

  Fly   262 FGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQ 326
            |..:.|    |:.|.|:|..:|.:.|.....|..|:.|....|.:|.:.......:..|:.|.|.
Human   209 FRPLAN----LRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLN 269

  Fly   327 YNAILEIKPATFAALLNLDTLDLSYNNLEFLEE-QIFGGNTLPRMRRLNLNGN-RMKHLHPLAFS 389
            .|.:..:.|..||.:|:|..|.|  ||:|.|.. ..|....||.:.:|::..| |:..:||.||.
Human   270 KNPLQRVGPGDFANMLHLKELGL--NNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFH 332

  Fly   390 SLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTF 454
            .||.:|.|.|.:|.|.:|                        :...:|||
Human   333 HLPQMETLMLNNNALSAL------------------------HQQTVESL--------------- 358

  Fly   455 LAKVNVSFPNLKRVAIEGNPWQCPCFVKLQHWLATR 490
                    |||:.|.:.|||.:|.|.::..:...||
Human   359 --------PNLQEVGLHGNPIRCDCVIRWANATGTR 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	48/155 (31%)
		LRR_8	104..164	CDD:290566	12/59 (20%)
		leucine-rich repeat	106..129	CDD:275380	2/22 (9%)
		leucine-rich repeat	130..153	CDD:275380	7/22 (32%)
		leucine-rich repeat	154..195	CDD:275380	12/43 (28%)
		LRR_RI	194..455	CDD:238064	76/262 (29%)
		LRR_8	194..254	CDD:290566	25/59 (42%)
		leucine-rich repeat	196..219	CDD:275380	13/22 (59%)
		leucine-rich repeat	220..243	CDD:275380	9/22 (41%)
		leucine-rich repeat	244..267	CDD:275380	6/22 (27%)
		LRR_8	271..330	CDD:290566	15/58 (26%)
		leucine-rich repeat	272..295	CDD:275380	7/22 (32%)
		leucine-rich repeat	296..319	CDD:275380	4/22 (18%)
		LRR_8	319..380	CDD:290566	20/62 (32%)
		leucine-rich repeat	320..343	CDD:275380	7/22 (32%)
		leucine-rich repeat	344..369	CDD:275380	9/25 (36%)
		LRR_8	368..428	CDD:290566	16/60 (27%)
		leucine-rich repeat	370..393	CDD:275380	8/23 (35%)
		leucine-rich repeat	394..417	CDD:275380	6/22 (27%)
		leucine-rich repeat	418..441	CDD:275380	3/22 (14%)
LRRN2	NP_006329.2	leucine-rich repeat	51..69	CDD:275380	8/46 (17%)
		LRR_RI	62..288	CDD:238064	72/258 (28%)
		LRR 1	70..91		7/33 (21%)
		leucine-rich repeat	71..94	CDD:275380	6/35 (17%)
		LRR 2	94..115		6/20 (30%)
		leucine-rich repeat	95..118	CDD:275380	5/22 (23%)
		LRR_8	117..177	CDD:290566	26/59 (44%)
		LRR 3	118..139		7/20 (35%)
		leucine-rich repeat	119..142	CDD:275380	7/22 (32%)
		LRR 4	142..163		11/20 (55%)
		leucine-rich repeat	143..166	CDD:275380	13/22 (59%)
		LRR_8	165..222	CDD:290566	19/60 (32%)
		LRR 5	166..187		8/20 (40%)
		leucine-rich repeat	167..190	CDD:275380	9/22 (41%)
		LRR 6	190..211		6/20 (30%)
		leucine-rich repeat	191..214	CDD:275380	6/22 (27%)
		LRR_RI	209..>372	CDD:238064	56/215 (26%)
		LRR_8	214..273	CDD:290566	16/62 (26%)
		LRR 7	214..235		7/24 (29%)
		leucine-rich repeat	215..238	CDD:275380	7/22 (32%)
		LRR 8	238..259		4/20 (20%)
		leucine-rich repeat	239..262	CDD:275380	4/22 (18%)
		LRR 9	262..283		6/20 (30%)
		leucine-rich repeat	263..286	CDD:275380	7/22 (32%)
		LRR 10	286..305		7/20 (35%)
		leucine-rich repeat	287..311	CDD:275380	9/25 (36%)
		LRR_8	310..371	CDD:290566	25/107 (23%)
		LRR 11	311..333		7/21 (33%)
		leucine-rich repeat	312..334	CDD:275380	7/21 (33%)
		LRR 12	336..357		6/44 (14%)
		leucine-rich repeat	337..360	CDD:275378	9/69 (13%)
		leucine-rich repeat	361..373	CDD:275378	5/11 (45%)
		TPKR_C2	369..412	CDD:301599	6/18 (33%)
		I-set	430..514	CDD:254352
		Ig	438..514	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910