DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and lrrc17

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_004913080.1	Gene:	lrrc17 / 101732309	XenbaseID:	XB-GENE-1010987	Length:	428	Species:	Xenopus tropicalis

Alignment Length:	409	Identity:	94/409 - (22%)
Similarity:	147/409 - (35%)	Gaps:	110/409 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 DLPHMPLLNRLELGHNRLVNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSS 232
            ||.|:.|...|   ...|.|..|....:::.|.|..|::|:::..||.||..|..|.|..|::..
Frog    77 DLIHILLARNL---IRILKNNAFSKFQKVKSLDLQQNEIIKIENLAFYGLKRLTTLLLQHNKIKV 138

  Fly   233 IGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLH--LQQLDLSGNRIRLLFDNQFRVLAR 295
            :..|.|..|..|..|.|..|..|.          |..|.  :..|.:..||   ...|..:....
Frog   139 LSEEVFIHLPLLSYLRLYDNPWDC----------NCELESLVTLLKIPRNR---NLGNYAKCETP 190

  Fly   296 LQMLDVSRNSIA--------SLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLN-----LDTL 347
            ::|..:...:::        ::.|.|..|....|             |...::|.:     :.||
Frog   191 IEMKGLKLKTVSPELICQDRTMEPQHIEGPKVTR-------------PIVDSSLCHTYLYPVATL 242

  Fly   348 DLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMF 412
            |.....|..:...|     .|.:.:|:|:.|::|.|....|...|.||.|.|..|.::.:|...|
Frog   243 DCRRKELHSVPTDI-----APDIVKLDLSNNKIKQLQSRQFVDTPNLEILNLNSNGIELIDPAAF 302

  Fly   413 APMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLAKVNVSFPNLKRVAIEGNPWQC 477
            :.:..||:|.|.:|.|..|:..|||.|..                       ||::.:..|||:|
Frog   303 SGLMNLQELDLSNNTLFYIHYGVLEDLYF-----------------------LKKLWLRDNPWRC 344

  Fly   478 PCFVK-LQHWLATRDVVYLRDNTGYYKGERPLCIVTNVDYCIQNLQAVRRLGILGDFQGE----- 536
            ...:. |.:||           ..:|          ||:|  ..|:........|.|.|.
Frog   345 DYNIHYLFYWL-----------KHHY----------NVNY--NGLECKSPEEYKGWFVGRYVRSY 386

  Fly   537 ---------QVEADAFDDD 546
                     ||:.|..:||
Frog   387 YEECPNEKFQVQVDEMEDD 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	27/87 (31%)
		LRR_8	104..164	CDD:290566
		leucine-rich repeat	106..129	CDD:275380
		leucine-rich repeat	130..153	CDD:275380
		leucine-rich repeat	154..195	CDD:275380	8/26 (31%)
		LRR_RI	194..455	CDD:238064	64/275 (23%)
		LRR_8	194..254	CDD:290566	19/59 (32%)
		leucine-rich repeat	196..219	CDD:275380	8/22 (36%)
		leucine-rich repeat	220..243	CDD:275380	7/22 (32%)
		leucine-rich repeat	244..267	CDD:275380	5/22 (23%)
		LRR_8	271..330	CDD:290566	9/68 (13%)
		leucine-rich repeat	272..295	CDD:275380	4/22 (18%)
		leucine-rich repeat	296..319	CDD:275380	4/30 (13%)
		LRR_8	319..380	CDD:290566	12/65 (18%)
		leucine-rich repeat	320..343	CDD:275380	3/22 (14%)
		leucine-rich repeat	344..369	CDD:275380	5/24 (21%)
		LRR_8	368..428	CDD:290566	20/59 (34%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..441	CDD:275380	11/22 (50%)
lrrc17	XP_004913080.1	leucine-rich repeat	58..77	CDD:275380	94/409 (23%)
		leucine-rich repeat	78..101	CDD:275380	7/25 (28%)
		LRR	<86..>319	CDD:227223	62/266 (23%)
		LRR_8	101..159	CDD:338972	18/57 (32%)
		leucine-rich repeat	102..125	CDD:275380	8/22 (36%)
		leucine-rich repeat	126..149	CDD:275380	7/22 (32%)
		leucine-rich repeat	150..211	CDD:275380	12/73 (16%)
		leucine-rich repeat	212..259	CDD:275380	11/64 (17%)
		leucine-rich repeat	260..283	CDD:275380	6/22 (27%)
		LRR_8	262..316	CDD:338972	18/53 (34%)
		leucine-rich repeat	284..307	CDD:275380	7/22 (32%)
		leucine-rich repeat	308..331	CDD:275380	11/22 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910