DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and podn

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_031756818.1	Gene:	podn / 101730272	XenbaseID:	XB-GENE-963382	Length:	598	Species:	Xenopus tropicalis

Alignment Length:	570	Identity:	150/570 - (26%)
Similarity:	232/570 - (40%)	Gaps:	132/570 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 CMG-----FP------ILHGADLCQPIGWRNFQCSEV-----ASLQDLVDLGAENWHTLAIRNVQ 65
            |.|     ||      |:|       :..:|.|..|:     ..|..|..|..:| :.|..|.:.
Frog    74 CAGVDLREFPSNLPDIIIH-------LSLQNNQIEEIPPEDLTRLYKLETLNLQN-NRLTSRGIP 130

  Fly    66 TELEVGSGENADHLANLLDLDLTGAAPINVHTNGFSILPNLRQLNLSGCGLVDIRGNHFAPESAL 130
            .:|       .:||..|..|.|.        .|..|:.|                  .|.| |:|
Frog   131 DDL-------FEHLEKLNYLYLA--------NNKLSLAP------------------RFLP-SSL 161

  Fly   131 QRIDFSHNQMELLDRDFFG---NLRKLIYANFSHNALKQCDLPHMPLLNR------LELGHNRLV 186
            ...||:.|.:..:....||   |||. :|.:  .|.|....:|. .:.||      |.|..|.|.
Frog   162 ISADFAANNITKIYEMTFGHKPNLRS-VYLH--DNKLTDAGIPD-NMFNRSNRVETLILSSNFLK 222

  Fly   187 NATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGL--ETFQPLAQLRKLNL 249
            .....:.|.|.:|.|.:|:|..:...||..|..|.||.|..||||:.|:  |||..|.:|..|:|
Frog   223 YVPKNLPPALCKLHLQNNKLESIPSGAFSHLTDLRELYLLNNRLSNEGMDNETFTKLNKLEYLDL 287

  Fly   250 SQNALDALRPNVFGAVQNFV-LHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIAS--LSP 311
            |.|.|..: |:  |..:|.| |||::     |.||.:.||....:..|:.|.:..|.:.:  :.|
Frog   288 SSNNLTKI-PS--GLPRNIVILHLEK-----NSIRFISDNVLTQIRNLEYLLLHNNKLRAHGIHP 344

  Fly   312 AHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLN 376
            ..||||..|..::: ||.:||..|.....  .:.||.|.:|.:..:.:..|....|  :..|||:
Frog   345 GAFVGLKKLHTVHV-YNNLLEKVPPGLPR--RVKTLMLLHNQISSISKNDFATTYL--LEDLNLS 404

  Fly   377 GNRMK--HLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESL 439
            .|::.  ::|..||..|..|:.|:|..|.|||:.   :...:.|:.|.|..|.:..|..|.|..:
Frog   405 YNKIMSGNVHKEAFRKLRLLKTLELSGNNLKSVP---YGLPKNLEILRLKDNDISSIPQDSLTGM 466

  Fly   440 SSVQEILVDNNRL---TFLAKVNVSFPNLKRVAIEGN-----PWQCPCFVKLQHWLATRDVVYLR 496
            ..::|..:.||:|   :|.:.......:|:.:.:.||     |...|         .|.:.:||:
Frog   467 IKLKEFYLSNNKLKLSSFYSGAWAELSSLQILDLSGNQLSYIPSDLP---------ETLEYLYLQ 522

  Fly   497 DNTGYYKGERPLCIVTNVDYCIQNLQAVR----RLGIL-------GDFQG 535
            .|.          |:|..|...::...::    |..:|       |.|:|
Frog   523 SNK----------IITVDDSAFESTPNIKGIFLRFNLLTAGSVKEGAFEG 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	51/163 (31%)
		LRR_8	104..164	CDD:290566	15/62 (24%)
		leucine-rich repeat	106..129	CDD:275380	2/22 (9%)
		leucine-rich repeat	130..153	CDD:275380	8/25 (32%)
		leucine-rich repeat	154..195	CDD:275380	10/46 (22%)
		LRR_RI	194..455	CDD:238064	86/270 (32%)
		LRR_8	194..254	CDD:290566	27/61 (44%)
		leucine-rich repeat	196..219	CDD:275380	8/22 (36%)
		leucine-rich repeat	220..243	CDD:275380	13/24 (54%)
		leucine-rich repeat	244..267	CDD:275380	8/22 (36%)
		LRR_8	271..330	CDD:290566	18/60 (30%)
		leucine-rich repeat	272..295	CDD:275380	6/22 (27%)
		leucine-rich repeat	296..319	CDD:275380	8/24 (33%)
		LRR_8	319..380	CDD:290566	16/60 (27%)
		leucine-rich repeat	320..343	CDD:275380	6/22 (27%)
		leucine-rich repeat	344..369	CDD:275380	6/24 (25%)
		LRR_8	368..428	CDD:290566	19/61 (31%)
		leucine-rich repeat	370..393	CDD:275380	8/24 (33%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..441	CDD:275380	7/22 (32%)
podn	XP_031756818.1	LRRNT	59..87	CDD:396168	4/12 (33%)
		leucine-rich repeat	90..113	CDD:275380	6/29 (21%)
		PLN00113	105..>512	CDD:215061	128/461 (28%)
		leucine-rich repeat	114..139	CDD:275380	8/32 (25%)
		leucine-rich repeat	140..184	CDD:275380	15/70 (21%)
		leucine-rich repeat	185..210	CDD:275380	8/28 (29%)
		leucine-rich repeat	211..231	CDD:275380	4/19 (21%)
		leucine-rich repeat	232..255	CDD:275380	8/22 (36%)
		leucine-rich repeat	256..281	CDD:275380	13/24 (54%)
		leucine-rich repeat	282..302	CDD:275380	8/22 (36%)
		leucine-rich repeat	303..326	CDD:275380	9/27 (33%)
		leucine-rich repeat	327..352	CDD:275380	8/24 (33%)
		leucine-rich repeat	353..373	CDD:275380	6/22 (27%)
		leucine-rich repeat	374..397	CDD:275380	5/22 (23%)
		leucine-rich repeat	398..423	CDD:275380	8/24 (33%)
		leucine-rich repeat	424..445	CDD:275380	7/23 (30%)
		leucine-rich repeat	446..468	CDD:275380	6/21 (29%)
		leucine-rich repeat	469..494	CDD:275380	5/24 (21%)
		leucine-rich repeat	495..515	CDD:275380	5/28 (18%)
		LRR_8	515..575	CDD:404697	12/58 (21%)
		leucine-rich repeat	516..539	CDD:275380	6/32 (19%)
		leucine-rich repeat	540..565	CDD:275380	5/23 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910