DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and Chadl

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_038936217.1	Gene:	Chadl / 100910434	RGDID:	6504353	Length:	747	Species:	Rattus norvegicus

Alignment Length:	302	Identity:	99/302 - (32%)
Similarity:	146/302 - (48%)	Gaps:	46/302 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 ETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLD 300
            :|...|.|  :|:|..|.|..:.|..|..:.    :|..|||...::..:.:..||.|.||..|:
  Rat    62 DTIPELTQ--RLDLQGNMLKVIPPAAFQDLP----YLTHLDLQHCQVEQVAEGAFRGLGRLLFLN 120

  Fly   301 VSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGN 365
            ::.|.::||......||||||:|.|:.|.:.|::|.||.||.:|.||:|::|.|.:|....|.|
  Rat   121 LASNRLSSLPQEALDGLGSLRRLELERNMLEELRPGTFGALGSLATLNLAHNALVYLPAMAFQG- 184

  Fly   366 TLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLL-- 428
             |.|.|.|.|:.|.:..|.|.|.:.||.|..|.|.||||::|.....:..|.|.:|.||||.|
  Rat   185 -LMRTRWLQLSHNALSVLAPEALAGLPVLRRLSLHHNELQALPGAALSQARSLARLELGHNPLTY 248

  Fly   429 --EEINLDVLESLSSVQEILVDN------------------------NRLTFLAKVNVSFPNLKR 467
              ||..|    :|..::|:.:|:                        |:||.|..:.|. ..|:|
  Rat   249 TGEEDGL----ALPGLRELALDHGSLQALGPRAFAHCPRLHTLDLRGNQLTTLPPLQVP-GQLRR 308

  Fly   468 VAIEGNPWQCPCFVK-LQHWLATRDVVYLRDNTGYYKGERPL 508
            :.::|||..|.|..: |..||....|    .:.|..:|.|.|
  Rat   309 LRLQGNPLWCACHARPLLEWLVRARV----RSDGACRGPRRL 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	7/19 (37%)
		LRR_8	104..164	CDD:290566
		leucine-rich repeat	106..129	CDD:275380
		leucine-rich repeat	130..153	CDD:275380
		leucine-rich repeat	154..195	CDD:275380
		LRR_RI	194..455	CDD:238064	82/246 (33%)
		LRR_8	194..254	CDD:290566	6/17 (35%)
		leucine-rich repeat	196..219	CDD:275380
		leucine-rich repeat	220..243	CDD:275380	2/6 (33%)
		leucine-rich repeat	244..267	CDD:275380	6/22 (27%)
		LRR_8	271..330	CDD:290566	22/58 (38%)
		leucine-rich repeat	272..295	CDD:275380	7/22 (32%)
		leucine-rich repeat	296..319	CDD:275380	7/22 (32%)
		LRR_8	319..380	CDD:290566	27/60 (45%)
		leucine-rich repeat	320..343	CDD:275380	11/22 (50%)
		leucine-rich repeat	344..369	CDD:275380	10/24 (42%)
		LRR_8	368..428	CDD:290566	25/59 (42%)
		leucine-rich repeat	370..393	CDD:275380	8/22 (36%)
		leucine-rich repeat	394..417	CDD:275380	8/22 (36%)
		leucine-rich repeat	418..441	CDD:275380	11/26 (42%)
Chadl	XP_038936217.1	PLN00113	30..>555	CDD:215061	99/302 (33%)
		leucine-rich repeat	48..66	CDD:275380	1/3 (33%)
		leucine-rich repeat	68..91	CDD:275380	7/28 (25%)
		leucine-rich repeat	92..115	CDD:275380	7/22 (32%)
		leucine-rich repeat	116..139	CDD:275380	7/22 (32%)
		leucine-rich repeat	140..163	CDD:275380	11/22 (50%)
		leucine-rich repeat	164..187	CDD:275380	10/24 (42%)
		leucine-rich repeat	188..211	CDD:275380	8/22 (36%)
		leucine-rich repeat	212..235	CDD:275380	8/22 (36%)
		leucine-rich repeat	236..259	CDD:275380	11/26 (42%)
		leucine-rich repeat	260..283	CDD:275380	2/22 (9%)
		leucine-rich repeat	306..345	CDD:275380	13/42 (31%)
		leucine-rich repeat	425..448	CDD:275380
		PPP1R42	446..603	CDD:411060
		leucine-rich repeat	449..472	CDD:275380
		leucine-rich repeat	473..496	CDD:275380
		leucine-rich repeat	497..520	CDD:275380
		leucine-rich repeat	521..544	CDD:275380
		leucine-rich repeat	545..568	CDD:275380
		leucine-rich repeat	569..592	CDD:275380
		LRR_8	591..653	CDD:404697
		leucine-rich repeat	593..617	CDD:275380
		leucine-rich repeat	618..641	CDD:275380
		leucine-rich repeat	643..665	CDD:275380
		leucine-rich repeat	666..677	CDD:275378
		LRRCT	673..721	CDD:214507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910