DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and phlpp1

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_004915365.2	Gene:	phlpp1 / 100497530	XenbaseID:	XB-GENE-6458029	Length:	1533	Species:	Xenopus tropicalis

Alignment Length:	458	Identity:	112/458 - (24%)
Similarity:	180/458 - (39%)	Gaps:	122/458 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 LNLSGCGLVDIRGNHFAPESALQRIDFSHNQME---------------LLDRDFFGNLRKLIYAN 158
            ::||.|.|      .:.||:.....|.:|..::               |.|...|..||.|   |
Frog   446 VDLSCCSL------EYLPENLFYSQDITHLNLKQNILRLSPGPAAEGTLDDLQRFTKLRSL---N 501

  Fly   159 FSHN-----ALKQCDLPHMPLLNRLELGHNRLVNATFGVCPQLQELILNDNQL------------ 206
            .|:|     .|..|.:|.:..|| |.....|.:.:..|....||..:|:.|.|
Frog   502 LSNNNLGSFPLAVCSIPTLTELN-LSCNALRAIPSQVGDMNNLQTFLLDGNYLQSLPAEMGNMHQ 565

  Fly   207 ---IQLDVNAFRGLHGLLE-------LQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDAL---R 258
               :.|..|.|..:..::|       |.:.||.|..:.|:|.:.::|::.::|..|.:..|   .
Frog   566 LNYLGLSFNEFTDIPEVVEKMASMDRLCMPGNALDILELQTLRKMSQIKHVDLRLNEIRGLVIDE 630

  Fly   259 PNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKL 323
            |       :|:.|:.||||..|:   |.|.....|:.|::|...||.:..|..:.|.    |:.|
Frog   631 P-------DFLPHITQLDLRDNK---LTDLDVTALSNLEVLHCERNRLRCLKISGFF----LKAL 681

  Fly   324 YLQYNAILEIK---------------------PATFAALLNLDTLDLSYNNLEFLEEQIFGGNTL 367
            |...|.:|.:.                     |..|:...||:.||:|:|:|..|.:::|..:.|
Frog   682 YASSNELLNLDVYPNPCYLSYMDISRNCLHSLPEWFSESRNLEVLDVSHNHLNELPDRLFCTSAL 746

  Fly   368 PRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEIN 432
               |:|.|..|:::.|..|..::.  ||.|.:.||:|..|...:...:..|:.|:...|.||.:.
Frog   747 ---RKLLLGYNQLQRLPELIENNQ--LEVLDVQHNQLLELPANLLLKLNSLRCLNASANHLETLP 806

  Fly   433 LDVL--ESLSSVQEILVDNNRL-------------------------TFLAKVNVSFPNLKRVAI 470
            ...|  ||.|.:||:.:.||.|                         ||.|........|:.:.|
Frog   807 ATCLSEESHSMLQELYLTNNNLTDKCVPLLMGHPHLKILHMAFNHLQTFPASKMAKLEELEEIDI 871

  Fly   471 EGN 473
            .||
Frog   872 SGN 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	43/188 (23%)
		LRR_8	104..164	CDD:290566	17/74 (23%)
		leucine-rich repeat	106..129	CDD:275380	6/19 (32%)
		leucine-rich repeat	130..153	CDD:275380	6/37 (16%)
		leucine-rich repeat	154..195	CDD:275380	12/45 (27%)
		LRR_RI	194..455	CDD:238064	81/333 (24%)
		LRR_8	194..254	CDD:290566	18/81 (22%)
		leucine-rich repeat	196..219	CDD:275380	8/37 (22%)
		leucine-rich repeat	220..243	CDD:275380	7/29 (24%)
		leucine-rich repeat	244..267	CDD:275380	4/25 (16%)
		LRR_8	271..330	CDD:290566	19/58 (33%)
		leucine-rich repeat	272..295	CDD:275380	8/22 (36%)
		leucine-rich repeat	296..319	CDD:275380	6/22 (27%)
		LRR_8	319..380	CDD:290566	21/81 (26%)
		leucine-rich repeat	320..343	CDD:275380	7/43 (16%)
		leucine-rich repeat	344..369	CDD:275380	9/24 (38%)
		LRR_8	368..428	CDD:290566	16/59 (27%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..441	CDD:275380	8/24 (33%)
phlpp1	XP_004915365.2	RA_PHLPP1	136..332	CDD:340760
		PH_PHLPP-like	339..435	CDD:270131
		PLN00113	406..>930	CDD:215061	112/458 (24%)
		leucine-rich repeat	443..465	CDD:275380	6/24 (25%)
		leucine-rich repeat	466..496	CDD:275380	4/29 (14%)
		leucine-rich repeat	497..519	CDD:275380	8/24 (33%)
		leucine-rich repeat	520..542	CDD:275380	5/22 (23%)
		leucine-rich repeat	543..565	CDD:275380	5/21 (24%)
		leucine-rich repeat	566..603	CDD:275380	8/36 (22%)
		leucine-rich repeat	614..636	CDD:275380	5/28 (18%)
		leucine-rich repeat	638..657	CDD:275380	8/21 (38%)
		leucine-rich repeat	658..699	CDD:275380	11/44 (25%)
		leucine-rich repeat	700..722	CDD:275380	2/21 (10%)
		leucine-rich repeat	723..745	CDD:275380	8/21 (38%)
		leucine-rich repeat	746..767	CDD:275380	7/23 (30%)
		leucine-rich repeat	768..791	CDD:275380	7/22 (32%)
		leucine-rich repeat	792..815	CDD:275380	7/22 (32%)
		leucine-rich repeat	818..841	CDD:275380	5/22 (23%)
		leucine-rich repeat	842..865	CDD:275380	3/22 (14%)
		leucine-rich repeat	911..933	CDD:275380
		PP2Cc	980..1229	CDD:214625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910