DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and slitrk2

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_004916940.1	Gene:	slitrk2 / 100497153	XenbaseID:	XB-GENE-964776	Length:	846	Species:	Xenopus tropicalis

Alignment Length:	513	Identity:	119/513 - (23%)
Similarity:	193/513 - (37%)	Gaps:	135/513 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 ANLLDLDLTGAAPINVHTNGFSILPNLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLD 144
            :.:..|.|.|.....::.|.|....|...|:|....|.:|:...|.....|:|:..::|::|:|.
Frog    62 SRIYQLFLNGNLLSRLYPNEFVNYSNAVTLHLGNNELQEIKTGAFNGLKTLKRLHLNNNKLEVLR 126

  Fly   145 RDFFGNLRKLIYANFSHNALKQCDLPHMPLLNRLELGHNRLVNATFGVCPQLQELILNDNQLIQL 209
            .:.|..|..|.|....:|.:...:......||:|::                  ||||||.|:.|
Frog   127 EETFQGLESLEYLQADYNFISIIEAGAFSKLNKLKV------------------LILNDNLLLSL 173

  Fly   210 DVNAFRGLHGLLELQLSGNRLSSIGLE-TFQPLAQLRKLNLSQNA-------------LDALRPN 260
            ..|.||.:. |..|.|.||||..:... ..:.:..:.::.|.:|.             ||.:  .
Frog   174 PNNVFRFVL-LTHLDLRGNRLKMLPFAGVLEHIGGIMEIQLEENPWNCTCDLIPLKAWLDTI--T 235

  Fly   261 VF-GAV---QNFVLH------LQQLDL---------------SGNRI------------------ 282
            || |.:   ..|.||      |.:.||               |..||
Frog   236 VFVGEIVCETPFRLHGKDVTQLTRQDLCPRKSSSDTNQRPAFSDPRIHRIPPTFNPAIIPTRVPK 300

  Fly   283 -------------RLLFDNQFRVLARLQMLD---------------VSRNSIASLS--------- 310
                         |:......::...:.:..               .|:||.:.|:
Frog   301 ASRPPKTRNRPTPRVTVSKDRQIFGPIMVYQTKSPVPLTCPESCVCTSQNSDSGLNINCQERKIS 365

  Fly   311 --------PAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTL 367
                    |.|      .|||||..|.:..:..|......:||.|.|..|.:..::|..|  :.|
Frog   366 NISDLQPKPTH------PRKLYLTGNYLQTVYKADLLEFGSLDLLHLGNNRIAMIQEGAF--SNL 422

  Fly   368 PRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEIN 432
            ..:|||.||||.::.|:|..|..|..|:||.|.:|.:|.:..|.|..:..||.|.|.:|||..:.
Frog   423 TSLRRLYLNGNYLEILYPSIFDGLYSLQYLYLEYNVIKDILPRTFDALSNLQLLFLNNNLLRSLP 487

  Fly   433 LDVLESLSSVQEILVDNNRLTFLAKVNV--SFPNLKRVAIEGNPWQCPC-FVKLQHWL 487
            .:|.|. :::..:.:.||..:.|....|  ......::.::.|||.|.| .:.|::|:
Frog   488 ENVFEG-TALTRLNLRNNHFSSLPAKGVLDQLTVFIQIDLQENPWDCNCDILGLKNWI 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	40/166 (24%)
		LRR_8	104..164	CDD:290566	16/59 (27%)
		leucine-rich repeat	106..129	CDD:275380	5/22 (23%)
		leucine-rich repeat	130..153	CDD:275380	7/22 (32%)
		leucine-rich repeat	154..195	CDD:275380	6/40 (15%)
		LRR_RI	194..455	CDD:238064	86/362 (24%)
		LRR_8	194..254	CDD:290566	20/73 (27%)
		leucine-rich repeat	196..219	CDD:275380	11/22 (50%)
		leucine-rich repeat	220..243	CDD:275380	7/23 (30%)
		leucine-rich repeat	244..267	CDD:275380	7/39 (18%)
		LRR_8	271..330	CDD:290566	20/142 (14%)
		leucine-rich repeat	272..295	CDD:275380	7/68 (10%)
		leucine-rich repeat	296..319	CDD:275380	6/54 (11%)
		LRR_8	319..380	CDD:290566	22/60 (37%)
		leucine-rich repeat	320..343	CDD:275380	7/22 (32%)
		leucine-rich repeat	344..369	CDD:275380	8/24 (33%)
		LRR_8	368..428	CDD:290566	24/59 (41%)
		leucine-rich repeat	370..393	CDD:275380	11/22 (50%)
		leucine-rich repeat	394..417	CDD:275380	8/22 (36%)
		leucine-rich repeat	418..441	CDD:275380	9/22 (41%)
slitrk2	XP_004916940.1	LRR	<44..>197	CDD:227223	42/153 (27%)
		leucine-rich repeat	66..87	CDD:275380	5/20 (25%)
		leucine-rich repeat	90..111	CDD:275380	5/20 (25%)
		LRR_8	111..170	CDD:338972	19/76 (25%)
		leucine-rich repeat	112..135	CDD:275380	7/22 (32%)
		leucine-rich repeat	136..159	CDD:275380	4/22 (18%)
		leucine-rich repeat	160..182	CDD:275380	12/39 (31%)
		leucine-rich repeat	183..207	CDD:275380	7/23 (30%)
		leucine-rich repeat	208..369	CDD:275380	21/162 (13%)
		TPKR_C2	216..>252	CDD:387596	9/37 (24%)
		leucine-rich repeat	370..400	CDD:275380	9/35 (26%)
		LRR_8	400..459	CDD:338972	24/60 (40%)
		leucine-rich repeat	401..424	CDD:275380	8/24 (33%)
		leucine-rich repeat	425..448	CDD:275380	11/22 (50%)
		leucine-rich repeat	449..468	CDD:275380	7/18 (39%)
		leucine-rich repeat	496..509	CDD:275378	2/12 (17%)
		leucine-rich repeat	521..533	CDD:275378	3/11 (27%)
		LRRCT	529..579	CDD:214507	7/16 (44%)
		Thioredoxin_like	728..>822	CDD:381987
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910