DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and lrrn1

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_002938357.1	Gene:	lrrn1 / 100492182	XenbaseID:	XB-GENE-18030784	Length:	718	Species:	Xenopus tropicalis

Alignment Length:	316	Identity:	82/316 - (25%)
Similarity:	150/316 - (47%)	Gaps:	34/316 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 RLVNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLN 248
            ||.|.|        ||.|:.|....:.......|..|..|.|..|::..:.....|.|..|::|.
Frog    94 RLFNLT--------ELDLSQNNFTSIQDVGLSNLSQLTTLHLEENQIFEMTDYCLQDLINLQELY 150

  Fly   249 LSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAH 313
            ::.|.|:::.|:.|..::|    |.:|.|:.|::|::....|.....|::|.:..|.:..:...:
Frog   151 INHNQLNSISPSAFSGLRN----LLRLHLNSNKLRIIDSRWFESTPNLEILMIGENPVIGILDFN 211

  Fly   314 FVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQI-----FGGNTLPRMRRL 373
            |..|.:||.|.|....:.:| |..  |||.||.|:    :|.|.:.::     .....:|.::.|
Frog   212 FQPLVNLRSLVLAGMYLSDI-PGN--ALLGLDNLE----SLSFYDNKLSKVPQLALQKVPNLKFL 269

  Fly   374 NLNGNRMKHLHPLAFSSLPFLEYLKLGHN---ELKSLDVRMFAPMRRLQKLHLGHN-LLEEINLD 434
            :||.|.::.:....|.::  |:..:||.|   ||.|:|......:..|.||...:| .|..|:..
Frog   270 DLNKNPIRKIQEGDFKNM--LKLKELGINNMAELVSVDRNALENLPELTKLEATNNPKLSYIHRS 332

  Fly   435 VLESLSSVQEILVDNNRLTFLAKVNV-SFPNLKRVAIEGNPWQCPCFVKLQHWLAT 489
            ...::.:::.::::||.|..:.:..| |.|||:.::|..||.:|.|.:   ||:.:
Frog   333 AFRNVPTLESLMLNNNALNSVYRGTVESLPNLREISIHSNPLRCDCVL---HWMGS 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	19/71 (27%)
		LRR_8	104..164	CDD:290566
		leucine-rich repeat	106..129	CDD:275380
		leucine-rich repeat	130..153	CDD:275380
		leucine-rich repeat	154..195	CDD:275380	4/10 (40%)
		LRR_RI	194..455	CDD:238064	66/269 (25%)
		LRR_8	194..254	CDD:290566	14/59 (24%)
		leucine-rich repeat	196..219	CDD:275380	5/22 (23%)
		leucine-rich repeat	220..243	CDD:275380	6/22 (27%)
		leucine-rich repeat	244..267	CDD:275380	6/22 (27%)
		LRR_8	271..330	CDD:290566	15/58 (26%)
		leucine-rich repeat	272..295	CDD:275380	6/22 (27%)
		leucine-rich repeat	296..319	CDD:275380	5/22 (23%)
		LRR_8	319..380	CDD:290566	19/65 (29%)
		leucine-rich repeat	320..343	CDD:275380	8/22 (36%)
		leucine-rich repeat	344..369	CDD:275380	5/29 (17%)
		LRR_8	368..428	CDD:290566	18/63 (29%)
		leucine-rich repeat	370..393	CDD:275380	5/22 (23%)
		leucine-rich repeat	394..417	CDD:275380	8/25 (32%)
		leucine-rich repeat	418..441	CDD:275380	6/23 (26%)
lrrn1	XP_002938357.1	LRRNT	33..76	CDD:214470
		LRR	<70..350	CDD:227223	69/276 (25%)
		leucine-rich repeat	75..97	CDD:275378	2/2 (100%)
		leucine-rich repeat	98..121	CDD:275380	6/30 (20%)
		leucine-rich repeat	122..145	CDD:275380	6/22 (27%)
		leucine-rich repeat	146..169	CDD:275380	6/22 (27%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		leucine-rich repeat	194..217	CDD:275380	5/22 (23%)
		leucine-rich repeat	218..241	CDD:275380	10/25 (40%)
		leucine-rich repeat	242..265	CDD:275380	3/26 (12%)
		leucine-rich repeat	266..289	CDD:275380	5/24 (21%)
		leucine-rich repeat	290..314	CDD:275380	7/23 (30%)
		leucine-rich repeat	315..336	CDD:275380	6/20 (30%)
		leucine-rich repeat	340..363	CDD:275378	5/22 (23%)
		leucine-rich repeat	364..376	CDD:275378	4/11 (36%)
		LRRCT	372..418	CDD:214507	6/17 (35%)
		I-set	431..518	CDD:369462
		fn3	538..602	CDD:365830
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910