Protein Alignment CG6749 and lrrc8e.2

DIOPT Version :9

• Sequence 1: NP_648354.1
• Gene: CG6749 / 39144
• FlyBaseID: FBgn0036040
• Length: 552
• Species: Drosophila melanogaster
• Sequence 2: XP_002935462.1
• Gene: lrrc8e.2 / 100490082
• XenbaseID: XB-GENE-22064203
• Length: 779
• Species: Xenopus tropicalis
• Alignment Length: 574
• Identity: 132/574 - (22%)
• Similarity: 234/574 - (40%)
• Gaps: 151/574 - (26%)

  Fly     4 TANWVLPLLLWLLCMGFPI-LHGA----DLCQP-----IGWRNFQCSE---------------VA 43
            |...|:.:|..::.:|:.. |.|.    .:|:|     :|:..|.|:.               :.
 Frog   238 TGQTVIKMLKVVVVLGYTFSLIGTFSFQHICKPAIQPLMGYTIFNCTHNLAFILEKLLLTYILLV 302

  Fly    44 SLQDLVDLGAENW---HTLAIRNVQTELEVGSGENAD------------HLANLLDLDLTGAAPI 93
            ||...:...|..|   |:|.:.:.  |.:.|..|..|            |:.:..|
 Frog   303 SLYTCLLAYALFWLCSHSLKVYSF--EKKQGGAELGDIPDVKKDFAFLLHMIDHYD--------- 356

  Fly    94 NVHTNGFSIL------PNLRQLNLSGCGLV---------DIRGNHFAPESALQRID---FSHNQM 140
            ::::..||:.      ..||::.|:....:         |.||......|.|..|.   ::..::
 Frog   357 SLYSKRFSVFLSAVSEGRLREMELNSEWTMEKLGEFVTKDTRGRRELQLSMLPAIPKAVYNLTEV 421

  Fly   141 ELLDRDFFGNLRKLIYANFSH-NALKQCDLPHMP----------LLNRLELGHNRLVNATFGVCP 194
            |:|..:...:.|  |....|. :||.:..|.|..          |.|:|::.|.|..:.. .:.|
 Frog   422 EVLKLELIASAR--ISGAVSRLSALTELHLIHCSTKMDTDAYCFLQNKLKVLHIRFTDLE-EIPP 483

  Fly   195 ------QLQELIL------NDNQLIQLDVNAFRGLHGLLELQLSGN-------------RLSSIG 234
                  .||||.|      ::|:.|:|  |:.|||..|..|.|:.|             :||.:.
 Frog   484 WIYNLKSLQELHLSGNLNSSNNKSIRL--NSLRGLTHLRALSLNSNVQHLPSAILDVAGQLSKLS 546

  Fly   235 LE----TFQPLAQLRKL-NLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFD-NQFRVL 293
            ::    |.....||::: .|.:..|...:.:....|.:.:|.||.:|||.|.:.::.: ..|:.|
 Frog   547 IQNGGTTLDGQTQLKRMKQLLEVELQDCQISKIPGVLSSLLSLQCIDLSSNLLNVVNEIGTFQRL 611

  Fly   294 ARLQMLDVSRNSIASLSPA--HFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEF 356
            ..|.:|.::.|:|..|.|:  |   |.:|.:|.:.:|. ||..|.:..:|:.|..:|:|:||::.
 Frog   612 RGLTILRLNHNAIGCLPPSIQH---LHNLEELSISHNR-LETIPTSLFSLVRLRNVDISHNNIKV 672

  Fly   357 LEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPF-------LEYLKLGHNELKSLDVRMFAP 414
            :..::   ..|.|:....:.||::        ||||.       |..||.|.|.|.||.. :|..
 Frog   673 IPLEV---GQLSRLEWFAVTGNQI--------SSLPHELCRCTRLRSLKAGFNNLSSLPT-VFNK 725

  Fly   415 MRRLQKLHLGHNLLEEINLDV------LESLSSVQEILVDNNRL----TFLAKV 458
            :..|..|.|..|.|..:.:::      |:...:|:|.::..:.|    .||.||
 Frog   726 LTLLSTLELAGNHLISLPVEIASCSLLLKGGLNVEEHVLKASPLEIKRKFLCKV 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	47/211 (22%)
		LRR_8	104..164	CDD:290566	14/72 (19%)
		leucine-rich repeat	106..129	CDD:275380	6/31 (19%)
		leucine-rich repeat	130..153	CDD:275380	4/25 (16%)
		leucine-rich repeat	154..195	CDD:275380	12/57 (21%)
		LRR_RI	194..455	CDD:238064	80/310 (26%)
		LRR_8	194..254	CDD:290566	23/89 (26%)
		leucine-rich repeat	196..219	CDD:275380	12/28 (43%)
		leucine-rich repeat	220..243	CDD:275380	7/39 (18%)
		leucine-rich repeat	244..267	CDD:275380	4/23 (17%)
		LRR_8	271..330	CDD:290566	19/61 (31%)
		leucine-rich repeat	272..295	CDD:275380	8/23 (35%)
		leucine-rich repeat	296..319	CDD:275380	8/24 (33%)
		LRR_8	319..380	CDD:290566	16/60 (27%)
		leucine-rich repeat	320..343	CDD:275380	7/22 (32%)
		leucine-rich repeat	344..369	CDD:275380	6/24 (25%)
		LRR_8	368..428	CDD:290566	20/66 (30%)
		leucine-rich repeat	370..393	CDD:275380	5/22 (23%)
		leucine-rich repeat	394..417	CDD:275380	9/22 (41%)
		leucine-rich repeat	418..441	CDD:275380	6/28 (21%)
lrrc8e.2	XP_002935462.1	Pannexin_like	1..313	CDD:372171	13/74 (18%)
		leucine-rich repeat	444..466	CDD:275380	4/21 (19%)
		LRR_8	467..527	CDD:338972	19/62 (31%)
		leucine-rich repeat	468..490	CDD:275380	4/22 (18%)
		leucine-rich repeat	491..518	CDD:275380	12/28 (43%)
		LRR	502..>776	CDD:227223	74/291 (25%)
		leucine-rich repeat	519..541	CDD:275380	4/21 (19%)
		leucine-rich repeat	542..565	CDD:275380	5/22 (23%)
		leucine-rich repeat	566..588	CDD:275380	3/21 (14%)
		leucine-rich repeat	589..613	CDD:275380	8/23 (35%)
		leucine-rich repeat	614..636	CDD:275380	8/24 (33%)
		leucine-rich repeat	637..659	CDD:275380	7/22 (32%)
		leucine-rich repeat	660..682	CDD:275380	6/24 (25%)
		leucine-rich repeat	706..728	CDD:275380	9/22 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910