DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6749 and igfals

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_002940278.2	Gene:	igfals / 100489984	XenbaseID:	XB-GENE-1008441	Length:	601	Species:	Xenopus tropicalis

Alignment Length:	508	Identity:	147/508 - (28%)
Similarity:	239/508 - (47%)	Gaps:	95/508 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 NFQCSEVASL--------------------------------QDLVDLGAENWHTLAIRNVQTEL 68
            |.|.|:||||                                |:||.|...|       |..|::
Frog    97 NLQSSQVASLEQQALHGLKALAHLHLERNMIKSLAPSTFTHTQNLVSLTLNN-------NFLTKI 154

  Fly    69 EVG--SGENADHLANLLDLDLTGAAPINVHTNGFSILPNLRQLNLSGCGLVDIRGNHFAPESALQ 131
            |.|  ||     |:||..|:|.....:.:....|..|.|||:|.|:|..||.::.:.|.....|:
Frog   155 EDGLFSG-----LSNLWYLNLGWNLLVVLPDMVFHDLLNLRELVLAGNRLVYLQPSLFLSLGELK 214

  Fly   132 RIDFSHNQMELLDRDFFGNLRKL--IYANFSH-NALKQCDLPHMPLLNRLELGHNRLV---NATF 190
            .:|.|.|.::.:..:.|...:|.  :|.|.:| :.:.......|..|..|:|.||||.   ..||
Frog   215 ELDLSGNSLKGIKANVFTRQQKTHKLYLNHNHISTVAPRAFSGMKNLRWLDLSHNRLTALYEDTF 279

  Fly   191 GVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALD 255
            ...|.|..|.|::|.|..|....|:.|..|:||.|..|::..:...||:.||||..|:|:.|.:.
Frog   280 FGLPSLNVLRLSNNSLTSLRPRIFKDLQFLVELNLGQNKIKILLERTFEGLAQLELLSLNHNNVQ 344

  Fly   256 ALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSL 320
            .:||..|..:.|..:    ::||||.::.|.::.|:.|.:|..|.:..:.::.:.|..|.||.|:
Frog   345 EIRPGSFLGLLNVAV----INLSGNCLKSLAEHCFKGLGKLHSLHMESSCLSHIKPQMFAGLSSI 405

  Fly   321 RKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHP 385
            |:|:||.|.|:.|:             |.|:.:|..|.|             |:|..|::.||..
Frog   406 RRLFLQNNEIVAIE-------------DHSFTDLHGLLE-------------LDLRSNKLTHLTT 444

  Fly   386 LAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNN 450
            .:|:.|..|.||.|..|::.::...:|:|:::||.|.|..|.|:.:..|:...|||::.:.:.||
Frog   445 RSFTGLKNLSYLLLSSNQILTISPEVFSPVQQLQWLDLSDNQLKALTEDIFLPLSSLRYLSLKNN 509

  Fly   451 RLTFLAKVNVSF----PNLKRVAIEGNPWQCPCFVKLQHWLATRDVVYLRDNT 499
               .|..::|:|    |.::::.:.||.|.|.|.:|     ..||:. ||::|
Frog   510 ---CLKTISVNFLIPPPTMQQLWLNGNQWDCGCALK-----GLRDLA-LRNST 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	52/158 (33%)
		LRR_8	104..164	CDD:290566	18/62 (29%)
		leucine-rich repeat	106..129	CDD:275380	8/22 (36%)
		leucine-rich repeat	130..153	CDD:275380	5/22 (23%)
		leucine-rich repeat	154..195	CDD:275380	13/46 (28%)
		LRR_RI	194..455	CDD:238064	79/260 (30%)
		LRR_8	194..254	CDD:290566	23/59 (39%)
		leucine-rich repeat	196..219	CDD:275380	8/22 (36%)
		leucine-rich repeat	220..243	CDD:275380	8/22 (36%)
		leucine-rich repeat	244..267	CDD:275380	7/22 (32%)
		LRR_8	271..330	CDD:290566	19/58 (33%)
		leucine-rich repeat	272..295	CDD:275380	7/22 (32%)
		leucine-rich repeat	296..319	CDD:275380	6/22 (27%)
		LRR_8	319..380	CDD:290566	16/60 (27%)
		leucine-rich repeat	320..343	CDD:275380	7/22 (32%)
		leucine-rich repeat	344..369	CDD:275380	5/24 (21%)
		LRR_8	368..428	CDD:290566	19/59 (32%)
		leucine-rich repeat	370..393	CDD:275380	7/22 (32%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..441	CDD:275380	8/22 (36%)
igfals	XP_002940278.2	leucine-rich repeat	69..92	CDD:275380
		PLN00113	71..>534	CDD:215061	137/481 (28%)
		leucine-rich repeat	93..116	CDD:275380	7/18 (39%)
		leucine-rich repeat	117..140	CDD:275380	0/22 (0%)
		leucine-rich repeat	141..164	CDD:275380	11/34 (32%)
		leucine-rich repeat	165..188	CDD:275380	5/22 (23%)
		leucine-rich repeat	189..212	CDD:275380	8/22 (36%)
		leucine-rich repeat	213..236	CDD:275380	5/22 (23%)
		leucine-rich repeat	237..260	CDD:275380	4/22 (18%)
		leucine-rich repeat	261..284	CDD:275380	9/22 (41%)
		leucine-rich repeat	285..308	CDD:275380	8/22 (36%)
		leucine-rich repeat	309..332	CDD:275380	8/22 (36%)
		leucine-rich repeat	333..354	CDD:275380	7/20 (35%)
		leucine-rich repeat	357..380	CDD:275380	7/26 (27%)
		leucine-rich repeat	381..404	CDD:275380	6/22 (27%)
		leucine-rich repeat	405..428	CDD:275380	10/35 (29%)
		leucine-rich repeat	429..450	CDD:275380	8/33 (24%)
		leucine-rich repeat	453..472	CDD:275380	5/18 (28%)
		leucine-rich repeat	477..500	CDD:275380	8/22 (36%)
		leucine-rich repeat	525..537	CDD:275378	3/11 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	164	1.000	Inparanoid score	I4082
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D299282at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.970