DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and lrrc32.1

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_004912272.1	Gene:	lrrc32.1 / 100489763	XenbaseID:	XB-GENE-994459	Length:	666	Species:	Xenopus tropicalis

Alignment Length:	592	Identity:	145/592 - (24%)
Similarity:	223/592 - (37%)	Gaps:	162/592 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 PNLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNAL---- 164
            |.::.|:||...|.:|..:|....|.|:.:|.|.||:..:....|..:.||...|.|.|.|
Frog    50 PGIQTLDLSHNDLENITEDHLMKYSFLESLDLSSNQLSFIQPHSFRKMHKLKEINLSGNDLDSFV 114

  Fly   165 --KQCDLPHMPLLNRLELGHNRLVNATFGV----CPQLQELILNDNQLIQLDVNAFRGLHGLLEL 223
              :...:..:|.:..|:|..|.|.|...|.    .|:||.|.|::|.:..:..:.|:|...|.|:
Frog   115 HHRVSGIGVLPYVQTLDLSRNSLYNDMIGYFLQEAPRLQYLSLHENSITTISSDLFQGSPLLAEV 179

  Fly   224 QLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLH----------------- 271
            .|..|.:..|...:|:.|..|..::||.|::..:  :.|...|..||:
Frog   180 DLHNNIIMDIEEGSFEYLKHLSMIDLSMNSITCI--SDFNLRQLKVLNLSKNSIKTFHTPDSEDE 242

  Fly   272 --LQQLDLSGNRI----------------------------------------RLLFDNQ----- 289
              |:::|||.|::                                        :|.|:.|
Frog   243 YLLEKVDLSHNKLSSFPQLPRVNNVIFIDLSKNYIHLGTETPGEDPDWMNYSFQLEFEEQNPKNI 307

  Fly   290 -FRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNN 353
             ...|.:|..||:|.|||.|:....|:.:.||..|.|..|.|..:....|:.|.:|.|||||.|:
Frog   308 STVPLPKLNHLDLSYNSIKSIPDDFFLTMPSLTFLNLSKNCIQVLSLGHFSGLSSLATLDLSANS 372

  Fly   354 LEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRR- 417
            ::.|.   .|.|:||.::||.|..|:::.|.|..|..|..:..|.|..|.:......:....||
Frog   373 IQNLS---LGANSLPSLQRLYLQHNQLRLLEPRIFQRLESIVLLHLQGNHVGPCMAGLGKAKRRT 434

  Fly   418 ---------------LQKLHLGHNLLEEI--------NLDVLESLSSVQEILVDNNRLTFLAK-- 457
                           ||.|:|..|:::.|        :|.||: ||....|.|..|.|..|.|
Frog   435 HAEEYRCVEFFNIPTLQHLNLRENMIQRIPASAFWGTSLKVLD-LSMNLGIKVKPNALFGLEKTL 498

  Fly   458 ------------VNVSFP---NLKRVAIEGN------PWQCPCFVKLQHWLATRDVVYLRDNTGY 501
                        :||..|   :||.:.:.||      .|...|      .|.|.| :.|...||.
Frog   499 EVLFMEGNGLPSLNVDLPLFTHLKYLNLSGNQLSELPEWNSDC------RLETLD-LSLNSFTGL 556

  Fly   502 YKGERP--------LCIVTNVDYCIQNL---QAVRRLGIL----------------GDFQGEQVE 539
            .....|        |.:..|...|..|.   ..:||..:.                |:...||::
Frog   557 EVSNIPVLENTLKTLSLYGNPLSCCANTWISHMIRRTAVTIVALNATTCNISKLYEGEMLVEQMD 621

  Fly   540 ADAFDDD 546
            .|..:.|
Frog   622 PDICEKD 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	46/161 (29%)
		LRR_8	104..164	CDD:290566	19/59 (32%)
		leucine-rich repeat	106..129	CDD:275380	6/22 (27%)
		leucine-rich repeat	130..153	CDD:275380	6/22 (27%)
		leucine-rich repeat	154..195	CDD:275380	12/50 (24%)
		LRR_RI	194..455	CDD:238064	89/349 (26%)
		LRR_8	194..254	CDD:290566	19/59 (32%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		leucine-rich repeat	220..243	CDD:275380	7/22 (32%)
		leucine-rich repeat	244..267	CDD:275380	5/22 (23%)
		LRR_8	271..330	CDD:290566	23/123 (19%)
		leucine-rich repeat	272..295	CDD:275380	9/68 (13%)
		leucine-rich repeat	296..319	CDD:275380	9/22 (41%)
		LRR_8	319..380	CDD:290566	24/60 (40%)
		leucine-rich repeat	320..343	CDD:275380	7/22 (32%)
		leucine-rich repeat	344..369	CDD:275380	11/24 (46%)
		LRR_8	368..428	CDD:290566	19/75 (25%)
		leucine-rich repeat	370..393	CDD:275380	8/22 (36%)
		leucine-rich repeat	394..417	CDD:275380	3/22 (14%)
		leucine-rich repeat	418..441	CDD:275380	10/30 (33%)
lrrc32.1	XP_004912272.1	LRR_8	50..110	CDD:404697	19/59 (32%)
		leucine-rich repeat	52..75	CDD:275380	6/22 (27%)
		leucine-rich repeat	76..99	CDD:275380	6/22 (27%)
		PLN00113	99..>579	CDD:215061	122/492 (25%)
		leucine-rich repeat	100..151	CDD:275380	12/50 (24%)
		leucine-rich repeat	152..175	CDD:275380	7/22 (32%)
		leucine-rich repeat	176..199	CDD:275380	7/22 (32%)
		leucine-rich repeat	200..220	CDD:275380	5/21 (24%)
		leucine-rich repeat	245..314	CDD:275380	9/68 (13%)
		leucine-rich repeat	315..338	CDD:275380	9/22 (41%)
		leucine-rich repeat	339..362	CDD:275380	7/22 (32%)
		leucine-rich repeat	363..385	CDD:275380	11/24 (46%)
		leucine-rich repeat	386..409	CDD:275380	8/22 (36%)
		leucine-rich repeat	410..449	CDD:275380	5/38 (13%)
		leucine-rich repeat	450..472	CDD:275380	6/21 (29%)
		leucine-rich repeat	473..520	CDD:275380	14/47 (30%)
		leucine-rich repeat	498..512	CDD:275378	0/13 (0%)
		leucine-rich repeat	521..542	CDD:275380	6/26 (23%)
		leucine-rich repeat	543..566	CDD:275380	7/23 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910