DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and tlrs5

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_002937550.2	Gene:	tlrs5 / 100489423	XenbaseID:	XB-GENE-22201327	Length:	653	Species:	Xenopus tropicalis

Alignment Length:	603	Identity:	144/603 - (23%)
Similarity:	222/603 - (36%)	Gaps:	178/603 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 SLQDLVDLGAENWHTLAIRNVQTELEVGSGENADH-LANLLDLDLTGAAPINVHTNGFSILPNLR 107
            |..||:.|     .||.:.:..|......|::|.. ..||:.|||.|...||:|...|..|..|.
Frog    74 SFPDLLHL-----QTLLLGSQVTPGTFSVGKSAFRGFPNLITLDLGGNRIINLHPEAFEGLSWLE 133

  Fly   108 QLNLSGCGLVD--IRGNHFAPESALQRIDFS-------------------------HNQMELLDR 145
            .|.|...||.:  :....|...::|:::|.|                         .|::.:|..
Frog   134 VLLLDHNGLDESVLESGMFKDLTSLKKLDLSFNNIRRVRPDPTFLKLSSISFLLLKFNKVSMLCG 198

  Fly   146 DFFGNL--RKLIYANFSHNALKQCDLPHM--PLLNRLELG------------------------- 181
            :...||  |:|...:.|.|.|:....||.  | .|.:.||
Frog   199 EDLQNLQGRRLQLLDMSSNPLQLSSTPHCTNP-FNNITLGTLDVSSMGWNAEMVENFVRTISGTQ 262

  Fly   182 ------------------HN----------------------------RLVNATFGVCPQLQELI 200
                              ||                            .||...|...|:|..|.
Frog   263 VDYIKMRHTAGLGSGFGFHNLKDPNKDTFSGLNSSNVQILDLSNGFISHLVPQLFSAFPKLLSLD 327

  Fly   201 LNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPL--AQLRKLNLSQNALDALRPNVFG 263
            |:.||:.::...||.||..|:.|.||||.|..:...:||.|  ..|:.|:||.|.:.|::   :|
Frog   328 LSSNQINRMSSGAFSGLGELVSLNLSGNLLGELMGSSFQGLGATSLKTLDLSSNHIGAVQ---YG 389

  Fly   264 AVQNFVLHLQQLDLSGNRIR-------------LLFDNQ----FRVLA---RLQMLDVSRNSIAS 308
            |:.:|.. |..|:|..|.:.             ||..|:    :.:::   ...:||:|.|.:..
Frog   390 ALDSFTA-LTSLNLRDNALNKIPPTKLQGVTFVLLKQNRISDIYNIISFCPHATILDLSSNRLTD 453

  Fly   309 L-SPAHFVGLGSLRKLYLQYNAILEIK-PAT--FAALLNLDTLDLSYNNLEFLEEQIFGGNT--- 366
            . |....:.|.||:.|.|..|::.... |.|  ......|..||||.|.|..:.:....|:.
Frog   454 FRSLWQILELQSLKYLSLASNSLYRCSLPHTSNITRTSGLVYLDLSDNALGPVLKSGECGDIFMH 518

  Fly   367 LPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEI 431
            |..::.|||..|::.::....|.||..|:.|.|..|..|.:...:|..:..|:.|:||.:.|..:
Frog   519 LGSLKSLNLARNQLSNIPDTMFRSLSSLQTLDLSGNGFKEIQSNLFTGLTALKTLNLGKSNLVTL 583

  Fly   432 NLDVLESLSSVQEILVDNNRLTFLAKVNVSFPNLKRVAIEGNPWQCPC----FVKLQHWLATRDV 492
            :..||:.|.|::.|  |.:.:|.:                     |.|    |.|   ||...:|
Frog   584 SSSVLDPLGSLESI--DLSEVTLV---------------------CDCSLWDFWK---WLEDTNV 622

  Fly   493 VYLRDNTGYYKGERPLCI 510
            ..   |.|   .:..|||
Frog   623 TV---NVG---KQEVLCI 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	55/256 (21%)
		LRR_8	104..164	CDD:290566	17/88 (19%)
		leucine-rich repeat	106..129	CDD:275380	6/24 (25%)
		leucine-rich repeat	130..153	CDD:275380	7/49 (14%)
		leucine-rich repeat	154..195	CDD:275380	15/113 (13%)
		LRR_RI	194..455	CDD:238064	83/289 (29%)
		LRR_8	194..254	CDD:290566	25/61 (41%)
		leucine-rich repeat	196..219	CDD:275380	9/22 (41%)
		leucine-rich repeat	220..243	CDD:275380	10/24 (42%)
		leucine-rich repeat	244..267	CDD:275380	8/22 (36%)
		LRR_8	271..330	CDD:290566	18/79 (23%)
		leucine-rich repeat	272..295	CDD:275380	7/42 (17%)
		leucine-rich repeat	296..319	CDD:275380	6/23 (26%)
		LRR_8	319..380	CDD:290566	20/66 (30%)
		leucine-rich repeat	320..343	CDD:275380	6/25 (24%)
		leucine-rich repeat	344..369	CDD:275380	9/27 (33%)
		LRR_8	368..428	CDD:290566	17/59 (29%)
		leucine-rich repeat	370..393	CDD:275380	7/22 (32%)
		leucine-rich repeat	394..417	CDD:275380	6/22 (27%)
		leucine-rich repeat	418..441	CDD:275380	8/22 (36%)
tlrs5	XP_002937550.2	PLN00113	100..>597	CDD:215061	121/501 (24%)
		leucine-rich repeat	108..131	CDD:275380	10/22 (45%)
		leucine-rich repeat	132..157	CDD:275380	6/24 (25%)
		leucine-rich repeat	158..182	CDD:275380	3/23 (13%)
		leucine-rich repeat	183..208	CDD:275380	4/24 (17%)
		leucine-rich repeat	209..232	CDD:275380	7/23 (30%)
		leucine-rich repeat	299..322	CDD:275380	3/22 (14%)
		leucine-rich repeat	323..346	CDD:275380	9/22 (41%)
		leucine-rich repeat	347..372	CDD:275380	10/24 (42%)
		leucine-rich repeat	373..396	CDD:275380	9/25 (36%)
		leucine-rich repeat	397..440	CDD:275380	7/42 (17%)
		leucine-rich repeat	418..431	CDD:275378	3/12 (25%)
		leucine-rich repeat	441..492	CDD:275380	13/50 (26%)
		leucine-rich repeat	493..521	CDD:275380	9/27 (33%)
		leucine-rich repeat	522..545	CDD:275380	7/22 (32%)
		leucine-rich repeat	546..569	CDD:275380	6/22 (27%)
		leucine-rich repeat	570..591	CDD:275380	7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910