DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and tlr14.3

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_004920451.1	Gene:	tlr14.3 / 100485201	XenbaseID:	XB-GENE-5909728	Length:	835	Species:	Xenopus tropicalis

Alignment Length:	521	Identity:	118/521 - (22%)
Similarity:	193/521 - (37%)	Gaps:	151/521 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 LLDLDLTGAAPINVHTNGFSILPNLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLDRD 146
            |::|||:.....::..:.|:...:||.||||...:..|....||....|..:...:|.:..:...
Frog    55 LVELDLSYNRLSHIQFDDFASFTHLRALNLSYNNISAIETGSFASNVLLTNLTLFNNSLTEMPSA 119

  Fly   147 FFGNLRKLIYANFSHN----ALKQCDLPHMPLLNRLELGH---NRLVNATFGVCP--QLQELI-- 200
            .|..||.|.:.:.|:|    |....:...:..|..|.:|.   ::::...|....  .||...
Frog   120 LFEPLRFLQFLDISNNFYNCATLGAEFSMLENLRNLSIGGPLVSKVLKGDFAPIKNISLQRFSLK 184

  Fly   201 ---------------LNDNQL---IQLDVNAFRGLHGLLELQLSGNRLSSI-------------G 234
                           ||...|   |.||.|. :.|..:|: .|:|...||:             .
Frog   185 TMSSLWLYEKGAFSDLNTQSLWLDIALDTNP-QALPRMLK-DLAGKAFSSLRFRNLFEFTYYTDA 247

  Fly   235 LETFQPLAQL------------------------RKLN--------------LSQNALD------ 255
            ::.|..||.:                        .|.|              ||.|..|
Frog   248 MDVFFGLADIFIKELTFYRGKFNENLLRLTLKNVEKSNIQDLFLLSIDFARSLSTNRTDIRINDL 312

  Fly   256 ALR---------PNV---------FGAVQ---------NFV--------LHLQQLDLSGNRIRLL 285
            |||         |::         |..|.         |||        :::::||:|.|  |||
Frog   313 ALRRLVIKDVTNPDILRFDWTFTWFNKVSHLDIINVNFNFVPCDAWSQMVNVERLDISNN--RLL 375

  Fly   286 FDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLS 350
            ..|.:.:|.:...|......|||.:        ::|.||     .|.:...|:.   .|.||||:
Frog   376 ASNLYNLLCQYSELPNLHTFIASDN--------NMRSLY-----TLSLLTLTWP---KLATLDLT 424

  Fly   351 YNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPF-LEYLKLGHNELKSLDVRMFAP 414
            .|.|..|:|..   ...|::.:|.|..|.:|   ...|..||. :|:|.:.::.|:.||:..|..
Frog   425 SNYLGALDEVC---TWTPQITKLILKDNTLK---VGVFKCLPVTVEHLDMSNSLLERLDMDYFNR 483

  Fly   415 MRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLAKVNV-SFPNLKRVAIEGNPWQCP 478
            ..:|:.|.|..|.|:.|:.|  ....::|.:.::.|..:.:.|.:. ..|.|:|:....||:.|.
Frog   484 ATKLKVLILSQNKLKFISRD--WKCPNLQVLGLEGNSFSVIDKGSFKDLPELRRLTAGDNPYHCT 546

  Fly   479 C 479
            |
Frog   547 C 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	46/238 (19%)
		LRR_8	104..164	CDD:290566	17/63 (27%)
		leucine-rich repeat	106..129	CDD:275380	9/22 (41%)
		leucine-rich repeat	130..153	CDD:275380	4/22 (18%)
		leucine-rich repeat	154..195	CDD:275380	8/49 (16%)
		LRR_RI	194..455	CDD:238064	83/375 (22%)
		LRR_8	194..254	CDD:290566	23/132 (17%)
		leucine-rich repeat	196..219	CDD:275380	10/42 (24%)
		leucine-rich repeat	220..243	CDD:275380	7/35 (20%)
		leucine-rich repeat	244..267	CDD:275380	12/93 (13%)
		LRR_8	271..330	CDD:290566	16/58 (28%)
		leucine-rich repeat	272..295	CDD:275380	9/22 (41%)
		leucine-rich repeat	296..319	CDD:275380	4/22 (18%)
		LRR_8	319..380	CDD:290566	18/60 (30%)
		leucine-rich repeat	320..343	CDD:275380	5/22 (23%)
		leucine-rich repeat	344..369	CDD:275380	9/24 (38%)
		LRR_8	368..428	CDD:290566	18/60 (30%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	6/22 (27%)
		leucine-rich repeat	418..441	CDD:275380	7/22 (32%)
tlr14.3	XP_004920451.1	LRR_8	54..113	CDD:338972	16/57 (28%)
		leucine-rich repeat	55..78	CDD:275378	5/22 (23%)
		leucine-rich repeat	79..102	CDD:275378	9/22 (41%)
		leucine-rich repeat	103..126	CDD:275378	4/22 (18%)
		leucine-rich repeat	127..151	CDD:275378	4/23 (17%)
		leucine-rich repeat	364..391	CDD:275380	10/28 (36%)
		leucine-rich repeat	392..417	CDD:275380	8/40 (20%)
		leucine-rich repeat	418..440	CDD:275380	9/24 (38%)
		leucine-rich repeat	441..462	CDD:275378	7/23 (30%)
		LRR_8	462..519	CDD:338972	15/58 (26%)
		leucine-rich repeat	463..486	CDD:275378	6/22 (27%)
		leucine-rich repeat	487..508	CDD:275378	7/22 (32%)
		leucine-rich repeat	509..532	CDD:275378	3/22 (14%)
		leucine-rich repeat	533..545	CDD:275378	4/11 (36%)
		TIR	651..788	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910